- Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease
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Rhee CK, Kim DK
- KMID: 2502012
- Korean J Intern Med.
- 2020 Mar;35(2):276-283.
- doi: 10.3904/kjim.2020.035
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast decreases neutrophil migration, restores cystic fibrosis... -
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- Pharmacotherapy for chronic obstructive pulmonary disease
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Kim IA, Park YB, Yoo KH
- KMID: 2420365
- J Korean Med Assoc.
- 2018 Sep;61(9):545-551.
- doi: 10.5124/jkma.2018.61.9.545
The goals of management of stable chronic obstructive pulmonary disease (COPD) are to reduce both current symptoms and future risks with minimal side effects from treatment. Identification and reduction of... -
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- Effect of a Dose-Escalation Regimen for Improving Adherence to Roflumilast in Patients with Chronic Obstructive Pulmonary Disease
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Hwang H, Shin JY, Park KR, Shin JO, Song KH, Park J, Park JW
- KMID: 2320700
- Tuberc Respir Dis.
- 2015 Oct;78(4):321-325.
- doi: 10.4046/trd.2015.78.4.321
BACKGROUND: The adverse effects of the phosphodiesterase-4 inhibitor roflumilast, appear to be more frequent in clinical practice than what was observed in chronic obstructive pulmonary disease (COPD) clinical trials. Thus,... -
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- Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis
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Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK
- KMID: 2165561
- Exp Neurobiol.
- 2015 Sep;24(3):246-251.
- doi: 10.5607/en.2015.24.3.246
Phosphodiesterases (PDEs) play a key role in the regulation of cyclic adenosine monophosphate (cAMP), which in turn mediates various cellular functions including learning and memory. We previously cloned and characterized... -
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- Electrophysiological and Behavioral Changes by Phosphodiesterase 4 Inhibitor in a Rat Model of Alcoholic Neuropathy
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Han KH, Kim SH, Jeong IC, Lee YH, Chang SJ, Park BN, Kim SW
- KMID: 2190520
- J Korean Neurosurg Soc.
- 2012 Jul;52(1):32-36.
- doi: 10.3340/jkns.2012.52.1.32
OBJECTIVE: Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of... -
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