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Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations

Kim KH, Kim SH, Jung HH, Moon JH, Jeong SU, Yu K, Lee CK

Thapsigargin (TGN) is a potent and selective inhibitor of sarco-endoplasmic Ca²⁺-ATPase, leading to rapid elevation of cytoplasmic Ca2+ concentration. Previous reports have shown that TGN increases the production of various...
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The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells

Bae CH, Chen SM, Lee HM, Song SY, Kim YD

  • KMID: 2166398
  • Clin Exp Otorhinolaryngol.
  • 2011 Dec;4(4):177-183.
OBJECTIVES: Doxycycline is commonly used in medicine for its bacteriostatic antimicrobial properties. Recent studies have reported that doxycycline also has anti-inflammatory effects. Matrix metalloproteinase (MMP)-9 has been found to be...
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Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells

Lee BH, Park RW, Kim IS

  • KMID: 755015
  • Exp Mol Med.
  • 1998 Dec;30(4):240-245.
We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Dibutyryl cAMP increased FN synthesis and mRNA levels, while PMA inhibited...
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