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The effect of rosehip extract on TNF-α, IL-1β, and IL-8 production in THP-1-derived macrophages infected with Aggregatibacter actinomycetemcomitans

Song Y, Kim Sy, Chung J

Inflammation is a protective mechanism against pathogens, but if maintained continuously, it destroys tissue structures. Aggregatibacter actinomycetemcomitans is a gram-negative, facultative anaerobic bacterium often found in severe periodontitis. A. actinomycetemcomitans...
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The effect of periodontitis on recipient outcomes after kidney transplantation

Min HJ, Park JS, Yang J, Yang J, Oh SW, Jo SK, Cho WY, Gwon JG, Jung CW, Seol YJ, Park SY, Kim MG

Background: Recent several reports have demonstrated that periodontitis is prevalent and adversely affects the survival in patients with chronic kidney disease (CKD) or end-stage kidney disease. However, its impact on...
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Association between soluble forms of the receptor for advanced glycation end products and periodontal disease: a retrospective study

Kim KS, Lee YJ, Ahn S, Chang YS, Choi Y, Lee HJ

Objectives: Periodontitis is the most common chronic disease that causes tooth loss and is related to systemic diseases such as cardiovascular dis- ease and diabetes. An objective indicator of the current...
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A step-by-step guide to random forest model using orange data mining in the field of periodontitis

Lim HJ

Objectives: The purpose of this study was to show a procedure for a random forest (RF) analysis which predicts periodontal disease status by using R and Orange Data Mining software,...
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A 2-plane micro-computed tomographic alveolar bone measurement approach in mice

Catunda RQ, Ho KKY, Patel S, Febbraio M

Purpose This study introduces a standardized 2-plane approach using 8 landmarks to assess alveolar bone levels in mice using micro-computed tomography. Materials and Methods Bone level differences were described as distance from the...
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Association of Gastroesophageal Reflux Disease with Preterm Birth: Machine Learning Analysis

Lee KS, Kim ES, Kim Dy, Song IS, Ahn KH

Background: This study used machine learning and population data for testing the associations of preterm birth with gastroesophageal reflux disease (GERD) and periodontitis. Methods: Retrospective cohort data came from Korea National...
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Evaluation of superoxide dismutase 3, heme-oxygenase, and myeloperoxidase expression levels associated with oxidative stress in chronic periodontitis

Yoon Y, Kim H, Lee JM

This study aimed to investigate the expression levels of antioxidative enzymes such as superoxide dismutase 3 (SOD3), heme-oxygenase (HO), and myeloperoxidase (MPOs), which are known to be associated with oxidative...
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Novel Compound Heterozygous Mutations in CTSC Gene in a Chinese Family with Papillon–Lefevre Syndrome

Wang Y, Zhang H, Feng S

Papillon–Lefevre syndrome (PLS) (OMIM: 245000) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early onset periodontitis, resulting in the premature loss of the deciduous and permanent teeth....
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Anti-inflammatory effect of non-thermal atmospheric pressure plasma for periodontitis treatment: in vitro pilot study

Park Yl, Kim HJ, Lee JY, Jeong SH, Kwon EY, Joo JY

Purpose: The purpose of this study was to evaluate the anti-inflammatory effects of non-thermal atmospheric pressure plasma (NTP) on human gingival fibroblasts (HGFs) for clinical application of periodontal treatment. Materials...
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Inhibitory effect of mangosteen peel and propolis ethanol extracts on alveolar bone loss against increased treatment amount of Porphyromonas gingivalis lipopolysaccharide in rat

Lee KH, Yoo SY, Kook JK, Sung SJ, Lee KW, Lim YK, Lee DS, Yu SJ

In previous studies, we introduced that mangosteen extract complex (MEC; ethanol extracts of Garcinia mangostana L. peel and propolis) had inhibitory effects on inflammation and alveolar bone loss in silk-ligature...
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Identification and characterization of a hemagglutinin gene from Prevotella intermedia

Lee SW, Okamoto M, Leung KP

In this study, we describe the cloning of a gene encoding hemagglutinin from Prevotella intermedia to characterize hemagglutinin function and elucidate its possible role in the infectious process mediated by...
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Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease

Kim WJ, Soh Y, Heo SM

Periodontal disease is primarily associated with bacterial infection such as dental plaque. Dental plaque, an oral biofilm harboring a complex microbial community, can cause various inflammatory reactions in periodontal tissue....
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Smoking and Drinking Adjusted Association between Head and Neck Cancers and Oral Health Status Related to Periodontitis: a Meta-Analysis

Vu H, Shin YJ, Kong MS, Kim HD

Background: Not so many reports about the association between head and neck cancer (HNC) and oral health status related to periodontitis (OHS-P) has been published in different countries with different...
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Orthodontic intrusion treatment of mandibular anterior teeth in a periodontal patient with hyperdivergent skeletal pattern: 8-year follow-up

Kwon EY, Jung KH, Park SB, Kim Ss, Kim Yi, Choi Yk

Patients who have extruded anterior teeth and deep bite with pathologic tooth migration, it is necessary not only periodontal treat-ment for reduce inflammation, but also orthodontic treatment for intrusion of...
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Analysis of Periodontitis Biomarker Expression in Gingival Crevicular Fluids

Hwang YS

Background: Periodontal disease, also known as gum disease, is a major dental inflammatory disease with a very high prevalence; it is the main cause of tooth loss. Therefore, diagnostic biomarkers...
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Natural Blue Pigment from Gardenia jasminoides Ellis (Rubiaceae) as a Dental Plaque Disclosant

Kim MH, Lee MH, Hwang YS

Background: Dental caries and periodontal disease are bacterial infectious disease, mainly caused by plaque, a bacterial colony deposited on the tooth surface and gum tissue. Dental plaque disclosants easily stain...
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Association obesity and periodontal disease - Using the Korean National Health and Nutrition Examination Survey (KNHANES) 2016-2018

Kim YS, Kim EK

Objectives: This study aimed to confirm the correlation between BMI and the prevalence of periodontal disease in adults, using data from the National Health and Nutrition Survey. Methods: The data included...
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Relationship Between Chronic Periodontitis and Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia

Hyun H, Park YW, Kwon YC, Cho BK, Lee JH

Purpose: We investigated the relationship between lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and chronic periodontitis (CP). Methods: A total of 103 middle-aged men who had received a health checkup...
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Lipopolysaccharides of Fusobacterium nucleatum and Porphyromonas gingivalis increase RANKL-expressing neutrophils in air pouches of mice

Kim AR, Lim YK, Kook JK, Bak EJ, Yoo YJ

Increases of neutrophils and osteoclasts are pathological changes of periodontitis. RANKL is an osteoclast differentiation factor. The effect of periodontopathogen LPS on RANKL-expressing neutrophils has not been clarified yet. We...
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High-salt and glucose diet attenuates alveolar bone recovery in a ligature-induced rat model of experimental periodontitis

Lee W, Lee SH, Kim MS, Choi EJ

Excessive intake of sodium caused by high salt diet promotes the expression of inflammatory cytokines and differentiation of helper T cells resulting in inflammatory responses. High-glucose diet also contributes to...
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