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Immunohistochemical Study of p53 and p21Waf1/Cip1 Expression in Several Epithelial Tumors of the Skin

Lee SH, Kim CW, Kim KH, Kim KJ, Park HR

  • KMID: 2302615
  • Korean J Dermatol.
  • 2005 Jun;43(6):788-795.
BACKGROUND: The p53 gene is one of a family of tumor suppressor genes that have been implicated in the genesis of a wide variety of malignant neoplasms including several epithelial...
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IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1

Yu SJ, Kim HS, Cho SW, Sohn J

  • KMID: 1094082
  • Exp Mol Med.
  • 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the...
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Involvement of mitogen-activated protein kinases and p21Waf1 in hydroxyurea-induced G1 arrest and senescence of McA-RH7777 rat hepatoma cell line

Hong SH, Hong BS, Kim DC, Rho MS, Park JI, Rha SH, Jun HS, Jeong JS

  • KMID: 1123771
  • Exp Mol Med.
  • 2004 Oct;36(5):493-498.
Hydroxyurea is commonly used to treat hematologic disorders and some type of solid tumors, but the mechanism for its therapeutic effect is not clearly known. In this study, we examined...
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Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary: a Report of Six Cases and Immunohistochemistry of the p53 Protein and p21WAF1/CIP1

Kim KH, Suh KS, Kim JH, Kang DW, Kim DH, Kim SH, Back JH, Park MJ

  • KMID: 2275534
  • Korean J Pathol.
  • 2003 Oct;37(5):316-319.
BACKGROUND: Mature cystic teratoma is a common type of ovarian tumor. Although squamous cell carcinoma (SCC) is the most common carcinoma in malignant transformations of ovarian mature cystic teratomas, SCC...
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Immunohistochemical Expression of p53, p21, and mdm2 Proteins in Human Papillomavirus Positive and Negative Invasive Uterine Cervical Carcinomas

Park IS, Han HS, Kim TS, Han JY, Kim JM, Chu YC, Hwang TS

  • KMID: 2275606
  • Korean J Pathol.
  • 2001 Jun;35(3):212-219.
BACKGROUND: In the uterine cervical carcinoma, the inactivation of p53 protein by human papillomavirus(HPV) E6 protein has been reported to play a greater role in carcinogenesis than the mutation of...
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Expression of Cell Cycle Regulatory and Apoptosis-related Proteins in Etoposide-treated Human Skin Fibroblast

Cho JW, Suh MH

  • KMID: 2007130
  • J Korean Cancer Assoc.
  • 2001 Feb;33(1):77-83.
PURPOSE: This study was designed to investigate effect of the etoposide on expression of cell cycle regulatory proteins and apoptosis-related proteins in human skin fibroblast (HSF). MATERIALS AND METHODS: HSF cells...
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p21WAF1/CIP1 Codon 31 Polymorphism in Korean Women: Association with Cervical Cancer Susceptibility and Prognosis

Roh JW, Kim KS, Kim JW, Kim MH, Chung HH, Park NH, Song YS, Kang SB, Lee HP

  • KMID: 2329190
  • J Korean Cancer Assoc.
  • 2000 Dec;32(6):1050-1058.
PURPOSE: The aim of this study was to determine whether certain genotype of p21WAF1/Cip1 might be associated with risk of cervical cancer in Korean women. MATERIALS AND METHODS: We used the...
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Topographic expression of p21WAF1/SDI1/CIP1, bcl2, and p53 is altered at the early stage of colorectal carcinogenesis

Cho JH, Roe IH, Lim CY, Park DK, Kim WH, Kim YI

We analyzed the expression of p21, bcl2, and p53 in normal and different pathologic mucosa of the human colorectum using immunohistochemistry and cold polymerase chain reaction-single strand conformation polymorphism. The topography...
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Enhancement of Tumor Radioresponse by Combined Chemotherapy in Murine Hepatocarcinoma

Seong J, Kim SH, Suh CO

  • KMID: 1571437
  • J Korean Soc Ther Radiol Oncol.
  • 2000 Dec;18(4):337-344.
BACKGROUNDS: The purpose of this study was to identify drugs that can enhance radioresponse of murine hepatocarcinoma. METHODS: C3H/HeJ mice bearing 8 mm tumors of murine hepatocarcinoma, HCa-I, were treated...
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Expression of p21WAF1/CIP1/SDI1 in Epithelial Ovarian Cancer ; Its Relationship with p53 Expression and Prognostic Factors

Kim BS, Lee SK, Lee JH, Kim SB

  • KMID: 2261174
  • Korean J Obstet Gynecol.
  • 1998 Sep;41(9):2447-2453.
The p21WAF1/CIP1/SDI1 protein is a potent inhibitor of cyclin dependent kinases. The tumor growth suppressor WAF1/CIP1/SDI1 was shown to be induced not only by p53 but also by other mechanisms....
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Mutational Analysis of p53, p21WAF1 and p16INK4a in Human Cervical Carcinomas

Suh SI, Choi EJ, Baek WK, Suh MH, Cho CH, Lee TS, Cha SD

  • KMID: 2146932
  • J Korean Soc Microbiol.
  • 1998 Aug;33(4):415-423.
Human papillomavirus (HPV) infection has been implicated to be an important causative factor for the development of cervical carcinoma. p53 gene mutation is common in human malignancies, and it is...
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The Expression and Correlation of Cyclin E, P21WAF1Protein and P53 Variant Protein in Colorectal Adenoma and Carcinoma

Kim JW, Ahn HJ, Choi SW, Ahn DH, Chung JS, Lee KP

  • KMID: 2101320
  • J Korean Soc Coloproctol.
  • 1998 Mar;14(1):51-58.
Cyclins are proteins that activate different cyclin-dependent kinases(CDKs) and promote the cell cycles. Their correlations with several human cancers have been identified. Cyclin E, as one of G1 cylins, produces...
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Inactivation of p73 Protein by Cervical Cancer-inducing HPV E6 Protein Novel p53-independent function of E6

Namkoong S, Kim SJ, Kim EJ, Um SJ, Park JS

  • KMID: 2026746
  • Korean J Obstet Gynecol.
  • 1998 Nov;41(11):2827-2834.
OBJECTIVE: Human papillomavirus (HPV) is strongly implicated as a causative agent in the etiology of cervical cancer. Of its gene products, E6 and E7 oncoproteins play major roles by inactivation...
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Induction of Apoptosis and Expression of Apoptosis-related Gene Products in Response to Radiation in Murine Tumors

Seong J, Hunter NR, Milas L

  • KMID: 2196471
  • J Korean Soc Ther Radiol.
  • 1997 Sep;15(3):187-196.
PURPOSE: To analyze the involvement of apoptosis regulatory genes p53, p21waf1/cip1, bax and bcl-2 in induction of apoptosis by radiation in murine tumors. MATERIALS AND METHODS: The radiation-sensitive ovarian carcinoma...
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