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Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice

Ranaweera SS, Dissanayake CY, Natraj P, Lee YJ, Han CH

Background: Sulforaphane (SFN) is an isothiocyanate compound present in cruciferous vegetables. Although the anti-inflammatory effects of SFN have been reported, the precise mechanism related to the inflammatory genes is poorly...
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Exendin-4 Improves Nonalcoholic Fatty Liver Disease by Regulating Glucose Transporter 4 Expression in ob/ob Mice

Kim S, Jung J, Kim H, Heo RW, Yi CO, Lee JE, Jeon BT, Kim WH, Hahm JR, Roh GS

Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of...
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Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

Choi HN, Jang YH, Kim MJ, Seo MJ, Kang BW, Jeong YK, Kim JI

  • KMID: 2313726
  • Nutr Res Pract.
  • 2014 Apr;8(2):172-176.
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective...
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Hog millet (Panicum miliaceum L.)-supplemented diet ameliorates hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice

Park MY, Jang HH, Kim JB, Yoon HN, Lee JY, Lee YM, Kim JH, Park DS

  • KMID: 2313558
  • Nutr Res Pract.
  • 2011 Dec;5(6):511-519.
Dietary intake of whole grains reduces the incidence of chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. In an earlier study, we showed that Panicum miliaceum L. extract...
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Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice

Hue JJ, Lee KN, Jeong JH, Lee SH, Lee YH, Jeong SW, Nam SY, Yun YW, Lee BJ

This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups...
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Increased Plasma Dipeptidyl Peptidase IV Activities in ob/ob Mice

Rhee SD, Lee YS, Lee HS, Jung WH, Cheon HG, Ahn JH, Kim SS, Paik SG, Yang SD

  • KMID: 2177801
  • J Korean Diabetes Assoc.
  • 2005 Jan;29(1):22-29.
BACKGROUND: Dipeptidyl peptidase IV (DPP IV/CD26), a multi-functional glycoprotein, cleaves and inactivates major insulinotropic hormones, such as glucagon-like protein (GLP)-1 and glucose dependent insulinotrophic polypeptide (GIP). METHODS: The plasma DPP...
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