- Lipopolysaccharide-induced Autophagy Increases SOX2-positive Astrocytes While Decreasing Neuronal Differentiation in the Adult Hippocampus
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Liu WC, Wu CW, Fu MH, Tain YL, Liang CK, Chen IC, Hung CY, Lee YC, Wu KL
- KMID: 2535062
- Exp Neurobiol.
- 2022 Oct;31(5):307-323.
- doi: 10.5607/en22005
Inflammation alters the neural stem cell (NSC) lineage from neuronal to astrogliogenesis. However, the underlying mechanism is elusive. Autophagy contributes to the decline in adult hippocampal neurogenesis under E. coli... -
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- Abnormal Development of Neural Stem Cell Niche in the Dentate Gyrus of Menkes Disease
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Cho Sk, Gwon S, Kim HA, Kim J, Cho SY, Kim DE, Chae JH, Park DH, Hwang YK
- KMID: 2532401
- Int J Stem Cells.
- 2022 Aug;15(3):270-282.
- doi: 10.15283/ijsc21088
Background and Objectives: Menkes disease (MNK) is a rare X-linked recessive disease, caused by mutations in the copper transporting ATP7A gene that is required for copper homeostasis. MNK patients experience... -
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- Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits
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Choi J, Kwon HJ, Seoh JY, Han PL
- KMID: 2524038
- Exp Neurobiol.
- 2021 Dec;30(6):415-429.
- doi: 10.5607/en21029
Hyperoxygenation therapy remediates neuronal injury and improves cognitive function in various animal models. In the present study, the optimal conditions for hyperoxygenation treatment of stress-induced maladaptive changes were investigated. Mice... -
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- Growth and Differentiation of Circulating Stem Cells After Extensive Ex Vivo Expansion
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Barbon S, Rajendran S, Bertalot T, Piccione M, Gasparella M, Parnigotto PP, Liddo RD, Conconi MT
- KMID: 2516528
- Tissue Eng Regen Med.
- 2021 Jun;18(3):411-427.
- doi: 10.1007/s13770-021-00330-7
BACKGROUND: Stem cell therapy is gaining momentum as an effective treatment strategy for degenerative diseases. Adult stem cells isolated from various sources (i.e., cord blood, bone marrow, adipose tissue) are being... -
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- Implications of Adult Neural Stem Cell Abnormalities in the Pathophysiological Mechanism of Schizophrenia
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Kim Y
- KMID: 2513554
- J Korean Neuropsychiatr Assoc.
- 2021 Feb;60(1):28-35.
- doi: 10.4306/jknpa.2021.60.1.28
Schizophrenia is a syndrome involving positive symptoms, negative symptoms, and cognitive decline due to several causes. The neuropathological findings of schizophrenia are unclear, but the age of onset of schizophrenia... -
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- Effects of the Prenatal Administration of Tetanus Toxoid on the Sociability and Explorative Behaviors of Rat Offspring: A Preliminary Study
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Sünnetçi E, Durankuş F, Albayrak Y, Erdoğan MA, Atasoy , Erbaş O
- KMID: 2513393
- Clin Psychopharmacol Neurosci.
- 2021 Feb;19(1):84-92.
- doi: 10.9758/cpn.2021.19.1.84
Objective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD,... -
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- Inhibition of LPA5 Activity Provides Long-Term Neuroprotection in Mice with Brain Ischemic Stroke
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Sapkota A, Park SJ, Choi JW
- KMID: 2508205
- Biomol Ther.
- 2020 Nov;28(6):512-518.
- doi: 10.4062/biomolther.2020.159
Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA5 activity with its specific... -
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- Improving Therapeutic Interventions of Schizophrenia with Advances in Stem Cell Technology
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Oltra oAE
- KMID: 2505653
- Clin Psychopharmacol Neurosci.
- 2020 Aug;18(3):352-361.
- doi: 10.9758/cpn.2020.18.3.352
Although historic documents posit schizophrenia to the beginnings of mankind, its diagnosis remains poorly defined, currently relying on unspecific clinical symptoms; and controversies still maintain its origin under intense debate.... -
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- L-histidine and L-carnosine exert anti-brain aging effects in D-galactose-induced aged neuronal cells
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Kim Y, Kim Y
- KMID: 2502480
- Nutr Res Pract.
- 2020 Jun;14(3):188-202.
- doi: 10.4162/nrp.2020.14.3.188
BACKGROUND/OBJECTIVES: Brain aging is a major risk factor for severe neurodegenerative diseases. Conversely, L-histidine and L-carnosine are known to exhibit neuroprotective effects. The aim of this study was to examine... -
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- Toluene Inhalation Causes Early Anxiety and Delayed Depression with Regulation of Dopamine Turnover, 5-HT1A Receptor, and Adult Neurogenesis in Mice
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Kim J, Lim J, Moon SH, Liu KH, Choi HJ
- KMID: 2500505
- Biomol Ther.
- 2020 May;28(3):282-291.
- doi: 10.4062/biomolther.2020.055
Inhaled solvents such as toluene are of particular concern due to their abuse potential that is easily exposed to the environment. The inhalation of toluene causes various behavioral problems, but,... -
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- Depression and Anxiety Disorder in Perspective of Neurogenesis and Pattern Separation
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Lee H, Kim YT
- KMID: 2517853
- J Korean Soc Biol Ther Psychiatry.
- 2020 Feb;26(1):5-13.
Major depressive disorder (MDD) and anxiety disorder (AD) are mental disorders with a high social burden. Since the discovery of neurogenesis, one effect of anti-depressant was revealed as increasing the... -
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- GABAergic neuronal development in the embryonic mesencephalon of mice
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- KMID: 2470119
- Korean J Vet Res.
- 2019 Dec;59(4):201-205.
- doi: 10.14405/kjvr.2019.59.4.201
This study presents neurogenesis and neuronal migration patterns of gamma-aminobutyric acid-ergic (GABAergic) neurons during mesencephalic development of mouse. After neurons from embryonic day (E) 10-16 were labelled by a single... -
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- Role of a 19S Proteasome Subunit- PSMD10(Gankyrin) in Neurogenesis of Human Neural Progenitor Cells
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Sahu I, Nanaware P, Mane M, Mulla SW, Roy S, Venkatraman P
- KMID: 2465887
- Int J Stem Cells.
- 2019 Nov;12(3):463-473.
- doi: 10.15283/ijsc19007
PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function... -
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- Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus
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Shin MS, Kim TW, Park SS, Ko IG, Kim CJ, Kim M, Roh SY, Kim KT, Kim KH
- KMID: 2452559
- Int Neurourol J.
- 2019 Jun;23(2):116-124.
- doi: 10.5213/inj.1938103.052
PURPOSE: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine... -
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- Neurogenesis and Regulation of Olfactory Epithelium
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Kim JS, Kim BG
- KMID: 2449021
- J Rhinol.
- 2019 May;26(1):1-7.
- doi: 10.18787/jr.2019.26.1.1
The olfactory epithelium is capable of structural and functional recovery after injury through neurogenesis. Neurogenesis occurs via stem cells in the olfactory epithelium. Horizontal basal cells and globose basal cells... -
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- Regulation of Neural Stem Cell Fate by Natural Products
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Kim HJ
- KMID: 2432062
- Biomol Ther.
- 2019 Jan;27(1):15-24.
- doi: 10.4062/biomolther.2018.184
Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent... -
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- Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus
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Kwon HJ, Jung HY, Hahn KR, Kim W, Kim JW, Yoo DY, Yoon YS, Hwang IK, Kim DW
- KMID: 2459301
- Lab Anim Res.
- 2018 Dec;34(4):239-247.
- doi: 10.5625/lar.2018.34.4.239
Bacopa monnieri is a medicinal plant with a long history of use in Ayurveda, especially in the treatment of poor memory and cognitive deficits. In the present study, we hypothesized... -
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- Repeated restraint stress promotes hippocampal neuronal cell ciliogenesis and proliferation in mice
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Lee K, Ko HW
- KMID: 2459296
- Lab Anim Res.
- 2018 Dec;34(4):203-210.
- doi: 10.5625/lar.2018.34.4.203
Stress severely disturbs physiological and mental homeostasis which includes adult neurogenesis in hippocampus. Neurogenesis in hippocampus is a key feature to adapt to environmental changes and highly regulated by multiple... -
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- Neurogenesis and neuronal migration of dopaminergic neurons during mesencephalon development in mice
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Kim MK, Lee SJ, Vasudevan , Won C
- KMID: 2435749
- J Biomed Transl Res.
- 2018 Dec;19(4):125-129.
- doi: 10.12729/jbtr.2018.19.4.125
Dopaminergic neurons are one of the major neuronal components in the brain. Mesencephalon dopamine (DA) neurogenesis takes place in the ventricular zone of the floor plate, when DA progenitors divide... -
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- Therapeutic Potential of Human Turbinate-Derived Mesenchymal Stem Cells in Experimental Acute Ischemic Stroke
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Lim H, Park SH, Kim SW, Cho KO
- KMID: 2426691
- Int Neurourol J.
- 2018 Oct;22(Suppl 3):S131-S138.
- doi: 10.5213/inj.1836220.110
PURPOSE: Mesenchymal stem cells (MSCs) have demonstrated great promises for the treatment of ischemic stroke. Previously, we identified a new source of MSCs located in the inferior turbinate. We investigated... -
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