- Absolute Neutrophil Count after the First Chemotherapy Cycle as a Surrogate Marker for Treatment Outcomes in Patients with Neuroblastoma
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Lee JW, Bae JS, Kim JH, Cho HW, Ju HY, Yoo KH, Koo HH, Woo Sy, Kim S, Sung KW
- KMID: 2524607
- Cancer Res Treat.
- 2022 Jan;54(1):259-268.
- doi: 10.4143/crt.2021.010
Purpose We performed this study to determine whether the degree of neutropenia after the first chemotherapy cycle can be used as a surrogate marker of individual susceptibility to chemotherapeutic agents... -
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- Propranolol Inhibits the Proliferation of Human Glioblastoma Cell Lines through Notch1 and Hes1 Signaling System
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Kim HS, Park YH, Lee HS, Kwon MJ, Song JH, Chang IB
- KMID: 2519698
- J Korean Neurosurg Soc.
- 2021 Sep;64(5):716-725.
- doi: 10.3340/jkns.2021.0068
Objective : The anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity in glioblastoma is not well-evaluated. The Notch-Hes pathway is known... -
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- Does the Incremental Value of 123 I-Metaiodobenzylguanidine SPECT/ CT over Planar Imaging Justify the Increase in Radiation Exposure?
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Ben-Sellem D, Ben-Rejeb N
- KMID: 2519270
- Nucl Med Mol Imaging.
- 2021 Aug;55(4):173-180.
- doi: 10.1007/s13139-021-00707-5
Purpose Planar scintigraphy with 123 I-radiolabeled metaiodobenzylguanidine (123 I-mIBG) is an important imaging modality to evaluate neuroblastoma. In recent years, Single Photon Emission Computed Tomography combined with Computed Tomography (SPECT/CT)... -
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- Survival Association and Cell Cycle Effects of B7H3 in Neuroblastoma
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Zhang H, Zhang J, Li C, Xu H, Dong R, Chen CC, Hua W
- KMID: 2508600
- J Korean Neurosurg Soc.
- 2020 Nov;63(6):707-716.
- doi: 10.3340/jkns.2019.0255
Objective : The function of B7H3, a member of the B7 family of proteins, in neuroblastoma (NB) remains poorly characterized. Here we examine the expression pattern of B7H3 in clinical... -
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- Pathology of Peripheral Neuroblastic Tumors
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Shimada H, Sano H, Hazard FK
- KMID: 2508195
- Clin Pediatr Hematol Oncol.
- 2020 Oct;27(2):73-86.
- doi: 10.15264/cpho.2020.27.2.73
Peripheral neuroblastic tumors (pNTs including Neuroblastoma, Ganglioneuroblastoma and Ganglioneuroma) are biologically and clinically heterogeneous. In order to develop efficient clinical treatment protocols of this disease, patients are stratified into different... -
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- Genome-Wide Association Study for the Identification of Novel Genetic Variants Associated with the Risk of Neuroblastoma in Korean Children
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Bae JS, Lee JW, Yoo JE, Joung JG, Yoo KH, Koo HH, Song YM, Sung KW
- KMID: 2507950
- Cancer Res Treat.
- 2020 Oct;52(4):1251-1261.
- doi: 10.4143/crt.2020.140
Purpose Neuroblastoma (NB) is the most common extracranial solid tumor found in children. To identify significant genetic factors for the risk of NB, several genetic studies was conducted mainly for Caucasians... -
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- Nomogram for predicting overall survival in children with neuroblastoma based on SEER database
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Liang SW, Chen G, Luo YG, Chen P, Gu JH, Xu QQ, Dang YW, Qin LT, Lu HP, Huang WT, Huang ZG, Gao L, Chen JB
- KMID: 2504824
- Ann Surg Treat Res.
- 2020 Aug;99(2):118-126.
- doi: 10.4174/astr.2020.99.2.118
Purpose: This study was performed to establish and validate a nomogram for predicting the overall survival in children with neuroblastoma. Methods: The latest clinical data of neuroblastoma in Surveillance, Epidemiology, and... -
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- Clinical Significance of Segmental Chromosomal Aberrations in Patients with Neuroblastoma: First Report in Korean Population
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Lim H, Son MH, Hyun JK, Cho HW, Ju HY, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2509613
- J Korean Med Sci.
- 2020 Apr;35(14):e82.
- doi: 10.3346/jkms.2020.35.e82
Background This study aimed to investigate the incidence and clinical significance of segmental chromosomal aberrations (SCAs) in Korean patients with neuroblastoma. Methods Patients diagnosed with neuroblastoma from 2012 to 2018 were included for... -
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- LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma
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Hwang M, Han MH, Park HH, Choi H, Lee KY, Lee YJ, Kim JM, Cheong JH, Ryu JI, Min KW, Oh YH, Ko Y, Koh SH
- KMID: 2463717
- Exp Neurobiol.
- 2019 Oct;28(5):628-641.
- doi: 10.5607/en.2019.28.5.628
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and... -
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- Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma
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Seo E, Kim JS, Ma YE, Cho HW, Ju HY, Lee SH, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2459423
- J Korean Med Sci.
- 2019 Oct;34(39):e254.
- doi: 10.3346/jkms.2019.34.e254
BACKGROUND: Neurotrophin-3 (NT-3), a member of the NT family, has only been considered an ancillary compound that provides anti-apoptotic benefits by inactivating tropomyosin receptor kinase C (TrkC)-induced apoptotic signals. However,... -
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- Deep learning for stage prediction in neuroblastoma using gene expression data
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Park A, Nam S
- KMID: 2462044
- Genomics Inform.
- 2019 Sep;17(3):e30.
- doi: 10.5808/GI.2019.17.3.e30
Neuroblastoma is a major cause of cancer death in early childhood, and its timely and correct diagnosis is critical. Gene expression datasets have recently been considered as a powerful tool... -
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- Patterns of recurrence after radiation therapy for high-risk neuroblastoma
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Jo JH, Ahn SD, Koh M, Kim JH, Lee SW, Song SY, Yoon SM, Kim YS, Kim SS, Park JH, Jung J, Choi EK
- KMID: 2460748
- Radiat Oncol J.
- 2019 Sep;37(3):224-231.
- doi: 10.3857/roj.2019.00353
PURPOSE: To investigate the patterns of recurrence in patients with neuroblastoma treated with radiation therapy to the primary tumor site. MATERIALS AND METHODS: We retrospectively analyzed patients with high-risk neuroblastoma managed... -
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- Mirror Syndrome Resulting from Metastatic Congenital Neuroblastoma to Placenta
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Park SH, Namgoong J, Ko KN, Kim CJ, Lee PR, Jung E, Lee BS, Kim KS, Kim EA
- KMID: 2430224
- Perinatology.
- 2018 Dec;29(4):189-194.
- doi: 10.14734/PN.2018.29.4.189
Congenital neuroblastoma is a rare disease. Placental metastasis is extremely rare and poor prognosis has been reported in neonates. Mirror syndrome could occur in mother with placental metastasis with possibilities... -
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- Two Cases of Adjuvant Immunotherapy with Cytokine-Induced Killer Cells for Relapsed or Refractory Neuroblastoma
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Choi JY, An HY, Hong KT, Hong C, Kang HJ, Shin HY
- KMID: 2435416
- Clin Pediatr Hematol Oncol.
- 2018 Oct;25(2):202-207.
- doi: 10.15264/cpho.2018.25.2.202
The treatment outcomes of relapsed or refractory neuroblastoma have been unsatisfactory till date. We reported two cases of adoptive immunotherapy using cytokine-induced killer (CIK) cells against relapsed or refractory neuroblastoma.... -
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- Clinical Significance of Random Urinary Vanillylmandelic Acid in Patients with Neuroblastoma
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Park E, Park H, Cho H, Ma Y, Lee SY, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2435406
- Clin Pediatr Hematol Oncol.
- 2018 Oct;25(2):142-148.
- doi: 10.15264/cpho.2018.25.2.142
BACKGROUND: To evaluate the value of random urinary vanillylmandelic acid (VMA) as a surrogate marker for monitoring tumor response and predicting outcome in patients with neuroblastoma (NB). METHODS: Medical records of... -
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- A Case of Infantile Nephrotic Syndrome associated with Neuroblastoma
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Kim SH, Park HM, Lee JH, Kim H, Go H, Kim DY, Park YS
- KMID: 2435378
- Child Kidney Dis.
- 2018 Oct;22(2):91-96.
- doi: 10.3339/jkspn.2018.22.2.91
Nephrotic syndrome in the first year of life, characterized by renal dysfunction and proteinuria, is associated with a heterogeneous group of disorders. These disorders are often related to genetic mutations,... -
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- Value of SPECT/CT in Diagnostic I-131 MIBG Scintigraphy in Patients with Neuroblastoma
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Theerakulpisut D, Raruenrom , Wongsurawat N, Somboonporn C
- KMID: 2422796
- Nucl Med Mol Imaging.
- 2018 Oct;52(5):350-358.
- doi: 10.1007/s13139-018-0532-y
PURPOSE: Diagnostic I-131 MIBG scintigraphy is an important imaging modality for evaluation of patients with neuroblastoma (NB) especially in centers where I-123 MIBG is not available. Single photon emission computed... -
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- Current Consensus on I-131 MIBG Therapy
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Kayano D, Kinuya S
- KMID: 2418989
- Nucl Med Mol Imaging.
- 2018 Aug;52(4):254-265.
- doi: 10.1007/s13139-018-0523-z
Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter norepinephrine and specifically targets neuroendocrine cells including some neuroendocrine tumors. Iodine-131 (I-131)-labeled MIBG (I-131 MIBG) therapy for neuroendocrine tumors has been performed... -
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- ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor
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Lee JW, Park SH, Kang HJ, Park KD, Shin HY, Ahn HS
- KMID: 2411138
- Cancer Res Treat.
- 2018 Apr;50(2):495-505.
- doi: 10.4143/crt.2016.577
PURPOSE: In this study, anaplastic lymphoma kinase (ALK) mutation and amplification, ALK protein expression, loss of the nuclear alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein, and telomerase reverse transcriptase (TERT)... -
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- Prenatally detected thoracic neuroblastoma
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Park Y, Lee HJ, Jung YJ, Lee JH, Kwon JY, Kim YH
- KMID: 2420184
- Obstet Gynecol Sci.
- 2018 Mar;61(2):278-281.
- doi: 10.5468/ogs.2018.61.2.278
Neuroblastoma is the most common pediatric extracranial solid tumor derived from primitive neural crest cells of the sympathetic nervous system. Although one-fifths of all neuroblastomas occurs within the thorax, thoracic... -
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