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Montelukast use over the past 20 years: monitoring of its effects and safety issues

Lee YJ, Kim CK

Montelukast, a leukotriene receptor antagonist, was launched 20 years ago in Korea. It is recommended as an alternative treatment for asthma in children with mild persistent symptoms or as an...
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A Double-Blind, Randomized, Crossover Study to Compare the Effectiveness of Montelukast on Atopic Dermatitis in Korean Children

Jeon YH, Min TK, Yang HJ, Pyun BY

PURPOSE: Some studies report a role of leukotrienes in the pathogenesis of atopic dermatitis and suggest a rationale for the use of leukotriene receptor antagonist (LTRA) in the treatment of...
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The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia

Kim SB, Lee JH, Lee J, Shin SH, Eun HS, Lee SM, Sohn JA, Kim HS, Choi BM, Park MS, Park KI, Namgung R, Park MS

PURPOSE: The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). METHODS: The Interventional study was designed as a multicenter,...
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Therapeutic Effect of Combination Treatment of Antihistamine and Montelukast in Allergic Rhinitis

Son HR, Lee KI, Chung YJ, Mo JH

  • KMID: 2297561
  • J Rhinol.
  • 2013 May;20(1):20-25.
BACKGROUND: Montelukast is a type 1 cysteinyl-leukotrienes receptor antagonist that has been widely used in allergic disease. However, the effect of combination of leukotriene receptor antagonist and antihistamine is controversial....
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Ratio of Leukotriene E4 to Exhaled Nitric Oxide and the Therapeutic Response in Children With Exercise-Induced Bronchoconstriction

Baek HS, Cho J, Kim JH, Oh JW, Lee HB

PURPOSE: This study assessed the association between the ratio of leukotriene E4 (LTE4) to fractional exhaled nitric oxide (FENO) in the response of children with exercise-induced bronchoconstriction (EIB) enrolled in...
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Montelukast as an add-on therapy in bronchopulmonary dysplasia

Kim HM, Song JE, Lee SM, Park MS, Park KI, Namgung R, Lee C

PURPOSE: Inflammation plays a potential role in the pathogenesis of bronchopulmonary dysplasia (BPD). Strategies for preventing BPD include respiratory management, antioxidants, nutritional treatment, and others such as anti-inflammatory agents. We...
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The Effect of Montelukast in the Treatment of Atopic Dermatitis through the SCORAD Index

Lee YK, Kim YH, Kim KH, Lee CW

  • KMID: 2087907
  • Korean J Dermatol.
  • 2008 Jan;46(1):34-39.
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease, with genetic and environmental background. The pathogenesis is complex, and although the dermatitis fades during childhood in most cases,...
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The Efficacy of Added Montelukast in Persistent Asthmatics Who Were Not Completely Controlled on Inhaled Corticosteroids and Inhaled Long-acting beta2-agonists

Choi JH, Park HS, Lee KH, Shim JJ, Uh ST, Lee SP, Lee YC, Choi WI, Kim JI, Lee JH, Lee MG, Jung KS

  • KMID: 2318967
  • Tuberc Respir Dis.
  • 2007 Oct;63(4):337-345.
BACKGROUNDS: Although glucocorticoids are one of the most potent anti-inflammatory agents, they have limited effect on cysteinyl leukotriene biosynthesis. In addition, the response to inhaled corticosteroids (ICS) and inhaled long-acting...
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The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model

Muz MH, Deveci F, Bulut Y, Ilhan N, Yekeler H, Turgut T

  • KMID: 1111403
  • Exp Mol Med.
  • 2006 Apr;38(2):109-118.
Airway structural changes that occur in patients with asthma in response to persistent inflammation are termed airway remodeling. The cysteinyl leukotrienes (LTC4, D4 and E4) are known to play important...
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Clinical effect of montelukast in exercise-induced asthma

Kim JH, Min UK, Choi SO, Lee SG, Hong SJ

  • KMID: 2285868
  • J Asthma Allergy Clin Immunol.
  • 2002 Dec;22(4):720-727.
BACKGROUND: Patients with bronchial asthma frequently have exercise-induced bronchocon striction. Exercise-induced bronchoconstriction limits the activities important for physical and social development in children. Leukotriene receptor antagonist has been shown to...
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