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Assessment of Mild Cognitive Impairment in Elderly Subjects Using a Fully Automated Brain Segmentation Software

Kwon C, Kang KM, Byun MS, Yi D, Song H, Lee JY, Hwang I, Yoo RE, Yun TJ, Choi SH, Kim Jh, Sohn CH, Lee DY, for the KBASE Research Group

Purpose: Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Brain atrophy in this disease spectrum begins in the medial temporal lobe structure, which can be recognized...
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Validity of the Montreal Cognitive Assessment (MoCA) Index Scores: a Comparison with the Cognitive Domain Scores of the Seoul Neuropsychological Screening Battery (SNSB)

Kim H, Yu KH, Lee BC, Kim BC, Kang Y

Background and Purpose: A new approach was proposed to score the Montreal Cognitive Assessment (MoCA) index scores for 6 cognitive domains: orientation (OIS), attention (AIS), language (LIS), visuospatial function (VIS),...
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Effects of Virtual Reality-Based Cognitive Training in the Elderly with and without Mild Cognitive Impairment

Maeng S, Hong JP, Kim WH, Kim H, Cho SE, Kang JM, Na KS, Oh SH, Park JW, Bae JN, Cho SJ

Objective This study aimed to introduce a 4-week long fully immersive virtual reality-based cognitive training (VRCT) program that could be applied for both a cognitively normal elderly population and patients...
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Early Detection of Mild Cognitive Impairment Using Visual Immediate Recall Test in the Community

Choo IH

Objective: Mild cognitive impairment (MCI) is transitional state between cognitively normal and dementia. It is not easy to detect MCI patient early in the community. This study aimed to detect...
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Predicting Mild Cognitive Impairment to Alzheimer’s Disease Transition: Role of Instrumental Activities of Daily Living

Woo SK, Bae S, Kim JH, Kim DK

Objective: This study aimed to investigate the association with the functioning of instrumental-activities of daily living (I-ADL) and future development of Alzheimer’s disease (AD) in persons with mild cognitive impairment...
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Correlation between fish consumption and the risk of mild cognitive impairment in the elderly living in rural areas

Yu A, Kim J, Choi BY, Kim MK, Yang Y, Yang YJ

Purpose: This study examines the correlation between fish consumption and the risk of mild cognitive impairment in the elderly living in rural areas. Methods: The Yangpyeong cohort data collected from Yangpyeong...
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Evaluation of Reproducibility of Brain Volumetry between Commercial Software, Inbrain and Established Research Purpose Method, FreeSurfer

J, JY, Oh SW, Chung MS, Park JE, Moon Y, Jeon HJ, Moon WJ

Background and Purpose We aimed to determine the intermethod reproducibility between the commercial software Inbrain (MIDAS IT) and the established research-purpose method FreeSurfer, as well as the effect of MRI...
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Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease

Chung JK, Jang JW, the Alzheimer’s Disease Neuroimaging Initiative

Background: A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the...
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Comparison of Automated Brain Volume Measures by NeuroQuant vs. Freesurfer in Patients with Mild Cognitive Impairment: Effect of Slice Thickness

Yim Y, Lee JY, Oh SW, Chung MS, Park JE, Moon Y, Jeon HJ, Moon WJ

Purpose: This study aimed to examine the inter-method reliability and volumetric differences between NeuroQuant (NQ) and Freesurfer (FS) using T1 volume imaging sequence with different slice thicknesses in patients with...
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Is Korea Prepared for an Alzheimer’s Disease-Modifying Therapy? Assessing the Korean Healthcare System Infrastructure and the Effect of Blood-Based Biomarker Tests

Jun H, Cho SK, Yoong J, Mattke S

Background: With the rapid demographic change in Korea, Alzheimer’s disease has become a primary concern. Recent developments in disease-modifying therapies provide hope that therapy may become available soon. The high...
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Trough Melatonin Levels Differ between Early and Late Phases of Alzheimer Disease

Lin CH, Chiu CC, Lane HY

Objective: Melatonin has been considered to have an essential role in the pathophysiology of Alzheimer’s disease (AD) for its regulatory function on circadian rhythm and interaction with glutamate for the...
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Structural Changes in the Hippocampal Subfields in Early-Onset Mild Cognitive Impairment

Moon SW, Yoo DY

  • KMID: 2513157
  • J Korean Soc Biol Ther Psychiatry.
  • 2021 Feb;27(1):67-73.
Objectives:The aim of this study was to examine the structural change in the hippocampal subfields in early-onset (EO) mild cognitive impairment (MCI) patients associated with the APOE ε4 carrier state. Methods:This...
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Amyloid Burden in Alzheimer's Disease Patients Is Associated with Alterations in Circadian Rhythm

Kang J, Choi HJ, Isaacs GD, Sung W, Kim HJ

Background and Purpose: In this study we evaluated the relationship between amyloid-beta (Aβ) deposition and 3 aspects of sleep quality in a group of clinically diagnosed Alzheimer's disease (AD) patients. Methods:...
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Comparison of RCF Scoring System to Clinical Decision for the Rey Complex Figure Using Machine-Learning Algorithm

Simfukwe C, An SS, Youn YC

Background and Purpose: Interpreting the Rey complex figure (RCF) requires a standard RCF scoring system and clinical decision by clinicians. The interpretation of RCF using clinical decision by clinicians might...
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Effect of Lifetime Cognitive Reserve on Functional Connectivity in the Default Mode Network at the Predementia Stage

Woo SK, Kang JM, Kim N, Lee SY, Kim S, Kim DJ, Kang CK, Lee JY, Cho SJ

Objective: Cognitive reserve (CR) protects against cognitive decline by utilizing functional connectivity (FC) in the brain, such as the default mode network (DMN). We studied whether CR in individuals with...
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A Comparison of the Performance between the 60- and 120-Second Conditions of the Korean-Color Word Stroop Test: Color Reading (K-CWST: CR)

Lee SH, Kang Y, Song M, Kim GH, Jeong JH

Background and Purpose: The Korean-Color Word Stroop Test: Color Reading (K-CWST: CR) included in the Seoul Neuropsychological Screening Battery, 2nd Edition (SNSB-II) examines inhibitory control deficit. It provides normative data for...
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A Comparison of Speech Features between Mild Cognitive Impairment and Healthy Aging Groups

Kim KW, Na SH, Chung YC, Shin BS

Background and Purpose: Language dysfunction is a symptom common to patients with Alzheimer's disease (AD). Speech feature analysis may be a patient-friendly screening test for early-stage AD. We aimed to...
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Development of Random Forest Algorithm Based Prediction Model of Alzheimer’s Disease Using Neurodegeneration Pattern

Kim J, Lee M, Lee MK, Wang SM, Kim NY, Kang DW, Um YH, Na HR, Woo YS, Lee CU, Bahk WM, Kim D, Lim HK

Objective Alzheimer’s disease (AD) is the most common type of dementia and the prevalence rapidly increased as the elderly population increased worldwide. In the contemporary model of AD, it is...
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The Association of Blood-Based Inflammatory Factors IL-1β, TGF-β and CRP with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment

Park JK, Lee KJ, Kim JY, Kim H

Objective Many patients suffer from dementia in its most common form, Alzheimer’s disease (AD). In this study, the levels of IL-1β, TGF-β and CRP, which are involved in the inflammatory...
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Four-Week, Home-Based, Robot Cognitive Intervention for Patients with Mild Cognitive Impairment: a Pilot Randomized Controlled Trial

Lee EH, Kim BR, Kim H, Kim SH, Chun MY, Park HK, Park KD, Jeong JH, Kim GH

Background and Purpose: Previous studies suggest that cognitive intervention can mitigate the development of dementia in patients with mild cognitive impairment (MCI). However, the previous cognitive intervention was mostly provided...
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