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Looking Back at Our 5-Year Experience of Paternity Testing: A Summary

Kim MY, Cho S, Lyoo SH, Lee JH, Seo HJ, Ryu WK, Jeong Y, Lee SD

We have been testing familial relationships based on short tandem repeats (STRs) in families who requested it either voluntarily or by order of the court. Here, we present a summary...
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Mixture Patterned Short Tandem Repeat Profile in a Perimortem Transfused Patient

Seo HJ, Cho S, Lee JH, Lyoo SH, Park S, Lee SD

Recently, it has been reported that transfused patients can generate admixture-like genetic profiles. As genetic material of the donor can survive for a reasonable time after transfusion, the recipient's genomic...
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Vitamin D Receptor Poly(A) Microsatellite Polymorphism and 25-Hydroxyvitamin D Serum Levels: Association with Susceptibility to Breast Cancer

Colagar AH, Firouzjah , Halalkhor

PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). There is growing evidence that breast cancer incidence is associated with...
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Markers for Screening Lynch Syndrome Are Reliable and Useful for Identifying the Specimen Mislabeling

Byeon SJ, Choi J, Nam KH, Jang BG, Lee HE, Kim MA, Kim WH

  • KMID: 2011980
  • Korean J Pathol.
  • 2012 Apr;46(2):131-136.
BACKGROUND: During specimen processing in surgical pathology laboratories, specimen-related adverse events (SRAEs), such as mislabeling and specimen mixed-up might occur. In these situations, molecular techniques using short tandem repeat (STR)...
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Gene mapping study for constitutive skin color in an isolated Mongolian population

Paik SH, Kim HJ, Son HY, Lee S, Im SW, Ju YS, Yeon JH, Jo SJ, Eun HC, Seo JS, Kwon OS, Kim JI

To elucidate the genes responsible for constitutive human skin color, we measured the extent of skin pigmentation in the buttock, representative of lifelong non-sun-exposed skin, and conducted a gene mapping...
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Clinical and pathologic characteristics of gastric cancer in elderly Korean patients in Korea

Kim YJ, Lee CH, Paik WH, Kim N, Park YS, Jung SH, Hwang JH, Lee KH, Jung HC, Song IS, Kim HH, Lee HS, Lee DH

  • KMID: 2256429
  • Korean J Med.
  • 2007 Mar;72(3):256-265.
BACKGROUND: Gastric cancer in elderly patients is one of the most important health issues in Korea, when considering its incidence and mortality rate. We have obtained the preliminary data concerning...
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Heterozygosities of 735 microsatellite markers and background linkage disequilibrium in the Korean population

Lee KA, Kim JW

  • KMID: 1115944
  • Exp Mol Med.
  • 2006 Dec;38(6):662-667.
Suitability of a specific population for linkage disequilibrium mapping studies of complex traits may be assessed by investigating the background linkage disequilibrium (BLD). We are unaware of studies for quantifying...
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Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma

Kang YK, Kim WH

  • KMID: 2275436
  • Korean J Pathol.
  • 2005 Feb;39(1):9-14.
BACKGROUND: To clarify the role of the mismatch repair (MMR) system in the carcinogenesis of intrahepatic cholangiocarcinoma (ICC), we investigated the microsatellite instability (MSI) status and MMR protein expression in...
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Hereditary neuropathy with liability to pressure palsies (HNPP) patients of Korean ancestry with chromosome 17p11.2-p12 deletion

Kim SM, Chung KW, Choi BO, Yoon ES, Choi JY, Park KD, Sunwoo IN

  • KMID: 755662
  • Exp Mol Med.
  • 2004 Feb;36(1):28-35.
Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant inherited disorder characterized by recurrent pressure palsies. Most HNPP patients have a 1.5 mb deletion in chromosome 17p11.2-p12....
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The Role of Microsatellite Instability at Chromosome 11p15.5 in the Progression of Breast Ductal Carcinoma

Kim DJ, Park JY, Lee MH, Sohn YK

The study of microsatellite instability (MSI) has provided the evidence to support asequential, progressive pathway for the development of cancer. In this study, we analyzed the role of MSI at...
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Characterization of Mutator Pathway in Younger-age-onset Colorectal Adenocarcinomas

Roh SA, Kim HC, Kim JS, Kim JC

The high-frequency microsatellite instability (MSI-H) phenotype, frequently identified in hereditary nonpolyposis colorectal cancer (HNPCC), also accounts for approximately 15% of sporadic colorectal cancers. Microsatellite instability (MSI) occurs from the mutational...
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Expression of MLH1, MSH2 in Malignant Melanoma

Kim YJ, Kim MG, Lee YS, Choi SH, Kim SY, Nam SY, Huh JR

  • KMID: 2037141
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 May;46(5):409-413.
BACKGROUND AND OBJECTIVES: MLH1 and MSH2, which are DNA mismatched repair genes, used to be studied in HNPCC (hereditary nonpolyposis colon cancer). Now, the defects in MLH1 and MSH2 are...
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p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach

Kim SS, Bhang CS, Min KO, Chae HS, Choi SW, Lee CD, Lim KW, Chung IS, Park DH

To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI)...
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Loss of Heterozygosity and PCR Artifacts in a Microsatellite Analysis of Psoriasis and Colorectal Cancer

Hyun JS, Jo BK, Park CJ, Yi JY, Lee JY, Rhyu MG

Although a loss of heterozygosity (LOH) is commonly observed using microsatellite markers in a cell-proliferating malignant disorder, controversial findings of psoriasis, a keratinocyte-outgrowth disease, remain to be explained. It...
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Microsatellite Instability in Colorectal Carcinomas

Cha HJ, Woo DK, Kim SH, Kim YL, Park JG, Kim WH

  • KMID: 2275640
  • Korean J Pathol.
  • 2001 Apr;35(2):111-114.
BACKGROUND: Microsatellite instability (MSI), which is caused by a deficient mismatch repair system, is seen in most of the hereditary non-polyposis colon cancers and a portion of sporadic colorectal cancers....
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beta-Catenin Expression in Gastric Carcinogenesis

Kang H, Choi YR, Kim H

  • KMID: 1725830
  • Korean J Pathol.
  • 2001 Oct;35(5):376-382.
BACKGROUND: The molecular pathogenesis of gastric carcinoma is not yet well characterized. The purpose of this study is to assess the role of beta-catenin in gastric carcinogenesis. METHODS: We analyzed...
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