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Neurological and Psychiatric Manifestations of Post-COVID-19 Conditions

Jung YH, Ha EH, Park J, Choe KW, Lee WJ, Jo DH

Background: We aimed to investigate the factors associated with neurological manifestations of post-coronavirus disease 2019 (COVID-19) conditions. Methods: We retrospectively collected data from 440 patients who visited our post-COVID-19 clinic more...
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Differential Encoding of Trace and Delay Fear Memory in the Entorhinal Cortex

Kong MS, Kim N, Jo KI, Kim SP, Choi JS

Trace fear conditioning is characterized by a stimulus-free trace interval (TI) between the conditioned stimulus (CS) and the unconditioned stimulus (US), which requires an array of brain structures to support...
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Subjective Cognitive Complaints in Cognitively Normal Patients With Parkinson’s Disease: A Systematic Review

Hong JY, Lee PH

Subjective cognitive complaints (SCCs) refer to self-perceived cognitive decline and are related to objective cognitive decline. SCCs in cognitively normal individuals are considered a preclinical sign of subsequent cognitive impairment...
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Structural Equation Modeling Based on PRECEDE Model for the Quality of Life in the Elderly with Dementia in Rural Area

Song MS, Kim HL

Purpose: This study was designed to test structural equation modeling of the quality of life of elderly diagnosed dementia living in the community in order to provide guidelines for development...
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Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain via regulation of brain-derived neurotropic factor

Sur B, Lee B

Memory formation in the hippocampus is formed and maintained by circadian clock genes during sleep. Sleep deprivation (SD) can lead to memory impairment and neuroinflammation, and there remains no effective...
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Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus

Kim S, Kim J, Park YM, Suh PG, Lee CJ

  • KMID: 2535064
  • Exp Neurobiol.
  • 2022 Oct;31(5):332-342.
  • doi: 10.5607/en22033
Visuosocial memory is defined as stored visual information containing social context. Primates have a powerful ability to associate visuosocial memory with episodic memory. However, the existence of visuosocial memory in...
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Potential Link Between Cognition and Motor Reserve in Patients With Parkinson’s Disease

Chung SJ, Kim YJ, Kim YJ, Lee HS, Yun M, Lee PH, Jeong Y, Sohn YH

Objective To investigate whether there is a link between cognitive function and motor reserve (i.e., individual capacity to cope with nigrostriatal dopamine depletion) in patients with newly diagnosed Parkinson’s disease...
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The Three Musketeers in the Medial Prefrontal Cortex: Subregion-specific Structural and Functional Plasticity Underlying Fear Memory Stages

Sung Y, Kaang BK

  • KMID: 2532833
  • Exp Neurobiol.
  • 2022 Aug;31(4):221-231.
  • doi: 10.5607/en22012
Fear memory recruits various brain regions with long-lasting brain-wide subcellular events. The medial prefrontal cortex processes the emotional and cognitive functions required for adequately handling fear memory. Several studies have...
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Development of Virtual Reality Neurocognitive Test for Mild Cognitive Impairment: Preliminary Study

Kang M, Roh HW, Son SJ, Chae H, Choi SW, Lee E, Seok JH, Jang S, Kim WJ

Objectives Mild cognitive impairment (MCI) is known to have a high rate of progression to Alzheimer’s disease. Early detection and intervention of MCI are of great interest in psychiatric and...
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Comparative Functional Connectivity of Core Brain Regions between Implicit and Explicit Memory Tasks Underlying Negative Emotion in General Anxiety Disorder

Park SE, Kim YH, Yang JC, Jeong GW

Objective: To investigate not only differential patterns of functional connectivity of core brain regions between implicit and explicit verbal memory tasks underlying negatively evoked emotional condition, but also correlations of...
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Working Memory Impairment in a Delayed Matching-to-Sample Task Among Young Male Patients With Obsessive-Compulsive Disorder

Objective : Impaired working memory has been known to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD) with growing evidence. Delayed matching-to-sample task (DMST) is a working...
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Generation of Highly Expandable Intestinal Spheroids Composed of Stem Cells

Kwon O, Kwon O, Yu WD, Yu WD, Son YS, Son YS, Jung KB, Jung KB, Lee H, Lee H, Son MY, Son MY

Many of early findings regarding intestinal stem cells (ISCs) and their niche in the human intestine have relied on colorectal cancer cell lines and labor-intensive and time-consuming mouse models. However,...
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Correlation between Alteration of Sharp-wave Ripple Coupled Cortical Oscillation and Long-term Memory Deficit in Alzheimer Disease Model Mice

Yang H, Jeong Y

  • KMID: 2524039
  • Exp Neurobiol.
  • 2021 Dec;30(6):430-440.
  • doi: 10.5607/en21046
Alzheimer’s disease (AD) is the most common cause of dementia, characterized by prominent episodic memory dysfunction. Recent studies have suggested that there is a sequential mechanism in the memory deficit,...
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Maternal Swimming Exercise During Pregnancy Improves Memory Through Enhancing Neurogenesis and Suppressing Apoptosis via Wnt/β-Catenin Pathway in Autistic Mice

Park SS, Kim CJ, Kim SH, Kim TW, Lee SJ

Purpose: Wnt pathway is closely related to neurodevelopmental process associated with cognitive function. After administration of valproic acid to the pregnant mice, the effect of swimming exercise of pregnant mice...
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Neuropsychological Domains Altered at the Early Stage of Cognitive Decline

Kim J, Park SJ, Lee DY, Ha J

Objective: A neuropsychological battery is a gold standard for thorough cognitive evaluation. However, it could not be used as a screening test due to its long inspection time and high...
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Exploring Autobiographical Memory Functions in Korean Older Adults: Development and Application of the Korean Version of Thinking About Life Experiences Scale

Park S, Lee CD, Kim TH

Objective: The aim of this study was to develop a Korean version of the Thinking About Life Experiences (TALE-K) scale and to analyze the characteristics of autobiographical memory function (AMF)...
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Musical Aptitude as a Variable in the Assessment of Working Memory and Selective Attention Tasks

Nisha KV, Neelamegarajan D, Nayagam NN, Winston JS, Anil SP

Background and Objectives: The influence of musical aptitude on cognitive test performance in musicians is a long-debated research question. Evidence points to the low performance of nonmusicians in visual and...
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Personalized Urination Activity Management Based on an Intelligent System Using a Wearable Device

Eun SJ, Lee JY, Jung H, Kim KH

Purpose: In this study, a urinary management system was established to collect and analyze urinary time and interval data detected through patient-worn smart bands, and the results of the analysis...
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Regulation of Macrophage Activation and Differentiation in Atherosclerosis

Park SH

Chronic inflammation is a hallmark of atherosclerosis and macrophages play a central role in controlling inflammation at all stages of atherosclerosis. In atherosclerosis, macrophages and monocyte-derived macrophages are continuously exposed...
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Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder

Si FF, Liu L, Li HM, Sun L, Cao QJ, Lu H, Wang YF, Qian QJ

Objective Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. The present study investigated the cortical morphology features and their relationship with working memory (WM). Methods In the...
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