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Histological Findings of Mammary Gland Development and Risk of Breast Cancer in BRCA1 Mutant Mouse Models

Kim H, Moon WK

Purpose: The breast cancer susceptibility gene, BRCA1, is involved in normal development and carcinogenesis of mammary glands. Here, we aimed to evaluate the relationship between histological findings of mammary gland...
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Tumorsphere formation and cancer stem cell characterization of REM134 canine mammary carcinoma cells

Byeon JS, Lee J, Jeong DU, Gu NY, Cho IS, Cha SH

Canine mammary tumors are among the most frequently observed cutaneous tumors in female dogs. Cancer stem cells (CSCs), referred to as tumor-initiating cells, are thought to have properties similar to...
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Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs

Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH

The inhibitory effect of neutering on mammary gland tumor development in dogs has been well described. However, we observed that the effect of neutering on tumor malignancy may be altered...
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Spectrum of Axillary Disorders (Excluding Metastasis from Breast Cancer): Radiological and Pathological Correlation: A Pictorial Essay

Kim HJ, Kim KW, Park YS, Chung DJ, Cho YJ, Hwang CM, Yoo HM, Kim YM, Lee MR

Axillary disorders originate from an axillary lymph node, subcutaneous fat layer, accessory breast, nerve, vessel and muscle. The most common causes of a palpable axillary mass are a lymph node...
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HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization and Immunohistochemical Expression of Topoisomerase II-alpha in the Breast Cancer

Lee TJ, Oh HG, Kwon GY, Kim MK, Park ES, Yoo JH

  • KMID: 1725953
  • Korean J Pathol.
  • 2003 Feb;37(1):26-34.
BACKGROUND: Amplifications of the HER-2/neu oncogene and the Topoisomerase II-alpha gene are important determiners of the response to chemotherapy in the breast cancer. For detecting HER-2/neu amplification, fluorescent in situ...
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Comparing Fluorescence In Situ Hybridization and Immunohistochemistry to Determine the HER-2/neu Status in Breast Carcinoma

Park K, Kim J, Lim S

  • KMID: 1725912
  • Korean J Pathol.
  • 2002 Aug;36(4):243-248.
BACKGROUND: Identification of HER-2/neu status is important in predicting the response to specific chemotherapy in breast carcinoma patients and HER-2/neu status is associated with poor clinical outcome even with systemic...
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Usefulness of Frozen Section Examination of Core Needle Biopsy in the Breast Carcinoma

Kim YJ, Chun YK, Hong SR, Kim HS, Kang SS, Lee JH, Lee SK, Kim HS

  • KMID: 1979381
  • Korean J Pathol.
  • 2002 Jun;36(3):163-166.
BACKGROUND: Core needle biopsy (CNB) is widely used as the initial sampling method for breast cancer. And because frozen section (FS) diagnosis is rapid and reliable, we studied the diagnostic...
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Allelic Loss at the BRCA1 and BRCA2 Loci in Sporadic Breast Carcinoma Using Paraffin Embedded Tissue

Park JY, Lee MH, Kim DJ, Park TI, Lee YH, Kim JW, Sohn YK

  • KMID: 2073727
  • Korean J Pathol.
  • 2002 Apr;36(2):100-105.
BACKGROUND: Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer susceptibility and a lifetime risk of breast. Several morphological and clinical features have been attributed to hereditary tumors....
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Recurrent Malignant Phyllodes Tumor with Liposarcoma

Lee JS, Kim HS, Jung JJ, Cho CD

  • KMID: 2275599
  • Korean J Pathol.
  • 2001 Dec;35(6):558-560.
Phyllodes tumors are an uncommon mammary tumors composed of benign epithelial elements and cellular, spindle cell stroma. Adipose differentiation is an uncommon stromal alteration in phyllodes tumors. Herein, a case...
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