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Pediatric management challenges of hyperglycemic hyperosmolar state: case series of Korean adolescents with type 2 diabetes

Lee S, Yoo S, Yoon JY, Cheon CK, Kim YA

The hyperglycemic hyperosmolar state (HHS) is considered the most fatal complication of type 2 diabetes mellitus (DM). The number of case reports describing pediatric HHS has increased recently in parallel...
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Focal Clonic Seizure Manifested in Diabetic Ketoacidosis

Park SM, Lee JJ, Yoo I, Kim YS, Kang K, Lee WW, Kim BK

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Dietary Changes Leading to Euglycemic Diabetic Ketoacidosis in Sodium-Glucose Cotransporter-2 Inhibitor Users: A Challenge for Primary Care Physicians?

Somagutta MKR, Uday U, Shama N, Bathula NR, Pendyala S, Mahadevaiah A, Mahmutaj G, Ngardig NN

Background: The use of euglycemic diabetic ketoacidosis (EDKA) related to sodium-glucose cotransporter 2 inhibitors (SGLT2i) use in people with diabetes has been increasingly reported. The causes are multifactorial, and dietary...
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COVID-19 and diabetes in children

Prosperi S, Chiarelli F

This review describes the impact of coronavirus disease 2019 (COVID-19) in children and adolescents, investigating changes in diabetes presentation during the COVID-19 pandemic, possible links between severe acute respiratory syndrome-coronavirus-2...
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Effect of the Concomitant Use of Subcutaneous Basal Insulin and Intravenous Insulin Infusion in the Treatment of Severe Hyperglycemic Patients

Lim Y, Ohn JH, Jeong J, Ryu J, Kim Sw, Cho JH, Park HS, Kim HW, Lee J, Kim ES, Kim NH, Jo YH, Jang HC

Background: No consensus exists regarding the early use of subcutaneous (SC) basal insulin facilitating the transition from continuous intravenous insulin infusion (CIII) to multiple SC insulin injections in patients with...
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Comparison of Initial Presentation of Pediatric Diabetes Before and During the Coronavirus Disease 2019 Pandemic Era

Lee Y, Kim M, Oh K, Kang E, Rhie YJ, Lee J, Hong YH, Shin YL, Kim JH

Background: Hospital visitation has become challenging during the coronavirus disease 2019 pandemic because of quarantine measures and fear of infection. Consequently, newly diagnosed patients may present with more severe diseases...
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Comparison of the clinical characteristics and outcomes of pediatric patients with and without diabetic ketoacidosis at the time of type 1 diabetes diagnosis

Seo YJ, Kum CD, Rho JG, Shim YS, Lee HS, Hwang JS

Purpose: We investigated the possible effects of diabetic ketoacidosis (DKA) at the initial diagnosis of type 1 diabetes mellitus (T1DM) on the clinical outcomes of pediatric patients. Methods: Medical records of...
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Hypertriglyceridemia with acute pancreatitis in a 14-year-old girl with diabetic ketoacidosis

Park H, Kim MS, Kim J, Lee SM, Cho SY, Yoo EG, Jin DK

Diabetic ketoacidosis (DKA) is a medically fatal condition in poorly controlled hyperglycemia or newly diagnosed diabetes mellitus. Severe hypertriglyceridemia (HTG) is an uncommon complication of DKA and can be associated...
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Significance of serial peripheral blood sugar test of diabetic ketoacidosis

Do G, Shin S

  • KMID: 2527385
  • J Korean Soc Emerg Med.
  • 2022 Feb;33(1):106-112.
Objective: Diabetic ketoacidosis is a severe disease condition causing fatalities in both type 1 and 2 diabetes. The management of this condition with fluid and insulin treatment is well documented....
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Sodium-Glucose Cotransporter-2 Inhibitor-Related Diabetic Ketoacidosis: Accuracy Verification of Operational Definition

Kang DY, Kim H, Ko S, Kim H, Shinn J, Kang MG, Byeon Sj, Choi JH, Shin SY, Kim HS

Background: The most important aspect of a retrospective cohort study is the operational definition (OP) of the disease. We developed a detailed OP for the detection of sodiumglucose cotransporter-2 inhibitors...
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Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study

Lee MS, Lee R, Ko CW, Moon JE

Background: The coronavirus disease 2019 (COVID-19) outbreak in the Daegu-Gyeongbuk area in 2020 has caused difficulties in the daily life and hospital care of children with type 1 diabetes mellitus...
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Cardiac Arrest Related to Torsades de Pointes in a Patient Recovering from Diabetic Ketoacidosis

Kim J, Lee JY, Yoo WS, Lee MY, Chung HK

Diabetic ketoacidosis (DKA) is an acute complication related to severe hyperglycemia. While the mortality rate for DKA is low with appropriate therapy, several complications may lead to deterioration of the...
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A case of diabetic ketoacidosis and hyperosmolar hyperglycemic state complicated with iatrogenic left femoral arterial thrombosis in a 14-year-old girl with newly diagnosed type 2 diabetes mellitus

Kim YJ, Kim YH

Although diabetic ketoacidosis (DKA) is a major cause of morbidity and mortality of type 1 diabetes mellitus, DKA also occurs in ketosis-prone type 2 diabetes. Recently, cases of DKA associated...
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Concurrent Diabetic Ketoacidosis and Acute Pancreatitis in Mild Hypertriglyceridemia: An Enigmatic Triangle

Cho E, Park CH

Hypertriglyceridemia (HTG) is a well-established cause of acute pancreatitis (AP). Diabetic ketoacidosis (DKA) leads to lipolysis and HTG, and can result in AP. Triad of AP, DKA, and HTG is...
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Diffuse Intracranial Hemorrhages, Acute Peripheral Neuropathy, and Acute Kidney Injury in a Newly Diagnosed Diabetes Patient with Severe Diabetic Ketoacidosis: A Case Report and Literature Review

Woo YJ, Hong HS, Choi SJ, Shin YL

Diabetic ketoacidosis (DKA) is a common complication associated with pediatric type 1 diabetes mellitus (DM). Although cerebral edema is the major cause of death in DKA, there is a possibility...
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A case of diabetic ketoacidosis with posterior cerebral artery territory ischemic stroke mimicking uncal herniation

Kim JH, Cho KU, Kim MS, Kim SJ

In diabetic ketoacidosis, hyperglycemia and ketosis result in cerebral vasculitis, which can cause cerebral edema and thrombosis. A previously healthy, 12-year-old girl visited the emergency department with a history of...
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Trends in Hyperglycemic Crisis Hospitalizations and in- and out-of-Hospital Mortality in the Last Decade Based on Korean National Health Insurance Claims Data

You JH, Song SO, Park SH, Park KH, Nam JY, Kim DW, Kim HM, Kim DJ, Lee YH, Lee BW

BACKGROUND: Hyperglycemic crisis is a metabolic emergency associated with diabetes mellitus. However, accurate epidemiologic information on cases of hyperglycemic crisis in Korea remains scarce. We evaluated trends in hyperglycemic crisis...
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Sodium-Glucose Cotransporter 2 Inhibitors for People with Type 1 Diabetes

Kim CH, Moon JS

Althowgh intensive insulin regimen is the main treatment in people with type 1 diabetes, glucose variability and weight gain remain as challenges for this treatment. Sodium-glucose cotransporter (SGLT) inhibitors (including...
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Delta Neutrophil Index is Useful to Predict Poor Outcomes in Male Patients with Alcoholic Ketoacidosis

Kim MK, Shin HW, Kim YJ, Yang JW, Kim JS, Han BG, Choi SO, Lee JY

BACKGROUND: Alcoholic ketoacidosis (AKA) is known as a benign disease, but the related mortality reported in Korea is high. Acidosis and alcohol change the immunity profile, and these changes can...
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A Rare Cause of Life-Threatening Ketoacidosis: Novel Compound Heterozygous OXCT1 Mutations Causing Succinyl-CoA:3-Ketoacid CoA Transferase Deficiency

Kim YA, Kim SH, Cheon CK, Kim YM

Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is a rare inborn error of ketone body utilization, characterized by episodic or permanent ketosis. SCOT deficiency is caused by mutations in the OXCT1 gene,...
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