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Cyclophosphamide-Associated Reversible Cerebral Vasoconstriction Syndrome Presenting as Concurrent Cerebral Infarction and Subarachnoid Hemorrhage

Jeong DY, Kim KW, Park YJ, Kim YJ, Chang JY

Reversible cerebral vasoconstriction syndrome (RCVS) has several trigger factors, including physical exertion, pregnancy, and the intake of vasoconstrictive agents. These triggers activate the sympathetic nervous system and induce vasoconstriction, thereby...
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Association between Plasma Osmolality and Case Fatality within 1 Year after Severe Acute Ischemic Stroke

Liu M, Deng Y, Cheng Y, Hao Z, Wu S, Liu M

Purpose: Plasma osmolality, a marker of dehydration, is associated with cardiovascular mortality. We aimed to investigate whether elevated plasma osmolality is associated with case fatality within 1 year after severe...
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Blood-brain barrier dysfunction in ischemic stroke and diabetes: the underlying link, mechanisms and future possible therapeutic targets

Wicha P, Das S, Mahakkanukrauh P

Ischemic stroke caused by occlusion of cerebral artery is responsible for the majority of stroke that increases the morbidity and mortality worldwide. Diabetes mellitus (DM) is a crucial risk factor...
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Pneumococcal meningitis complicated by otomastoiditis and pneumocephalus confounding an acute ischemic stroke diagnosis

Malinovic M, Peterson J, Lee F

Background: Approximately one-fourth of admissions to stroke centers are diagnosed with non-stroke conditions or stroke mimics. Differentiating between these diagnoses and acute ischemic stroke is an important and time-sensitive task....
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Role of continuous hypertonic saline in acute ischemic infarcts: a systematic literature review

Chugh AJS, Maynard M, Sunshine K, Shammassian BH, Sauer A, Odetoyinbo K, Hoffer SA

Continuous hypertonic saline for hemispheric ischemic infarcts has been routinely used in neurocritical centers for the management of malignant cerebral edema. However, the data supporting its use are extremely limited....
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Long-Term Changes in Post-Stroke Depression, Emotional Incontinence, and Anger

Kwon B, Lee EJ, Park S, Lee JS, Lee MH, Jeong D, Lee D, Kwon HS, Chang DI, Park JH, Cha JK, Heo JH, Sohn SI, Kim DE, Choi-Kwon S, Kim JS

Background and Purpose Long-term changes in post-stroke depression (PSD), post-stroke emotional incontinence (PSEI), and post-stroke anger (PSA) have rarely been studied. Methods This is a sub-study of EMOTION, a randomized, placebo-controlled...
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Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study

Olindo S, Chausson N, Signate A, Mecharles S, Hennequin JL, Saint-Vil M, Edimonana-Kaptue M, Jeannin S, Landais A, Cabre P, Sibon I, Smadja D, Joux J

Background and Purpose Carotid web (CaW) is an intimal variant of fibromuscular dysplasia responsible for ipsilateral cerebral ischemic events (CIE). Symptomatic CaW likely has a high risk of recurrent CIE,...
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Automated Prediction of Ischemic Brain Tissue Fate from Multiphase Computed Tomographic Angiography in Patients with Acute Ischemic Stroke Using Machine Learning

Qiu W, Kuang H, Ospel JM, Hill MD, Demchuk AM, Goyal M, Menon BK

Background and Purpose Multiphase computed tomographic angiography (mCTA) provides time variant images of pial vasculature supplying brain in patients with acute ischemic stroke (AIS). To develop a machine learning (ML)...
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Upregulation of miR-20b Protects Against Cerebral Ischemic Stroke by Targeting Thioredoxin Interacting Protein (TXNIP)

Yang D, Tan Y, Li H, Zhang X, Li X, Zhou F

  • KMID: 2515815
  • Exp Neurobiol.
  • 2021 Apr;30(2):170-182.
  • doi: 10.5607/en20046
Dysregulation of microRNAs (miRNAs) is involved in abnormal development and pathophysiology in the brain. Although miR-20b plays essential roles in various human diseases, its function in cerebral ischemic stroke remains...
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Dynamics of T Lymphocyte between the Periphery and the Brain from the Acute to the Chronic Phase Following Ischemic Stroke in Mice

Kim M, Kim SD, Kim KI, Jeon EH, Kim MG, Lim YR, Lkhagva-Yondon E, Oh Y, Na K, Chung YC, Jin BK, Song YS, Jeon MS

  • KMID: 2515814
  • Exp Neurobiol.
  • 2021 Apr;30(2):155-169.
  • doi: 10.5607/en20062
Stroke causes systemic immunosuppression. T lymphocytes are involved in infarct size in the early stages of stroke. However, the phenotypes of T lymphocytes and their functions in peripheral immune organs...
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Targeting the culprit: vessel wall magnetic resonance imaging for evaluating stroke

Kim SM, Ha SH, Kwon H, Kim YJ, Ahn SH, Kim BJ

The pathogenesis of many strokes originates in the vessel wall. Despite this, most traditional imaging focuses on the vascular lumen. Vessel-wall magnetic resonance imaging (VWMRI) is useful for establishing the...
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Association between Serum Insulin-Like Growth Factor-1 and Neurological Severity in Acute Ischemic Stroke

Lee J, Lee J, Lee M, Lim JS, Kim JH, Yu KH, Oh MS, Lee BC

Background and Purpose Serum insulin-like growth factor-1 (IGF-1) is known to have a neuroprotective effect. This study aimed to determine the effects of serum IGF-1 on the severity and clinical...
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Inhibition of Long Noncoding RNA SNHG15 Ameliorates Hypoxia/Ischemia-Induced Neuronal Damage by Regulating miR-302a-3p/STAT1/NF-κB Axis

Hu C, Li C, Ma Q, Wang R, He Y, Wang H, Luo G

Purpose: Ischemic brain injury results in high mortality and serious neurologic morbidity. Here, we explored the role of SNHG15 in modulating neuronal damage and microglial inflammation after ischemia stroke. Materials and...
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Effect of Transport Time on the Use of Reperfusion Therapy for Patients with Acute Ischemic Stroke in Korea

Choi JC, Kim JG, Kang CH, Bae HJ, Kang J, Lee SJ, Park JM, Park TH, Cho YJ, Lee KB, Lee J, Kim DE, Cha JK, Kim JT, Lee BC, Lee JS, Kim AS

Background: We investigated the association between geographic proximity to hospitals and the administration rate of reperfusion therapy for acute ischemic stroke. Methods: We identified patients with acute ischemic stroke who visited...
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How to differentiate intracranial atherosclerotic disease or vasospasms after mechanical thrombectomy. Be patient or vasodilator is the secret?

Pagiola I, Amaral B, Saito C, Nalli D, Carrete Junior H, Frudit M

Here we describe a successful mechanical thrombectomy (MT) for acute large vessel occlusion in stroke treatment with one passage (thrombolysis in cerebral infarction, TICI 3). Immediately after the withdrawing of...
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Clinical outcomes among hemodialysis patients with atrial fibrillation: a Korean nationwide population-based study

Kang Y, Choi HY, Kwon YE, Shin JH, Won EM, Yang KH, Oh HJ, Ryu DR

Background: The number of patients requiring dialysis is increasing worldwide, and the atrial fibrillation and atrial flutter (AF) prevalence among hemodialysis (HD) patients is higher than in the general population....
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Intravenous Thrombolysis and Endovascular Thrombectomy in Acute Ischemic Stroke with Minor Symptom

Kim DH

More than 50% of all patients with ischemic stroke initially present with mild symptoms. Despite the mild clinical presentation, a high percentage of these patients develop stroke progression with consequent...
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Platelet-Derived Growth Factor Is Associated with Progression of Symptomatic Intracranial Atherosclerotic Stenosis

Kim KJ, Jeong SW, Ryu WS, Kim DE, Saver JL, Kim JS, Kwon SU, TOSS-2 Study Group

Background and Purpose We aimed to determine the relationships of 33 biomarkers of inflammation, oxidation, and adipokines with the risk of progression of symptomatic intracranial atherosclerotic stenosis (ICAS). Methods Fifty-two of...
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Characteristics of Acute Stroke in Patients with Coronavirus Disease 2019 and Challenges in Stroke Management during an Epidemic

Kwon DH, Do Y, Eun MY, Lee J, Park H, Sohn SI, Hong JH

Coronavirus disease 2019 (COVID-19) is an ongoing pandemic infection associated with high morbidity and mortality. The Korean city of Daegu endured the first large COVID-19 outbreak outside of China. Since...
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High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils

Seo WJ, Ahn JH, Lee TK, Kim B, Lee JC, Park JH, Yoo YH, Shin MC, Cho JH, Won MH, Park Y

Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia...
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