- Evaluation of MET alteration in EGFR-mutant non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitor from paired biopsy: A retrospective cohort study
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Ku BM, Park S, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Choi YL, Ahn MJ
- KMID: 2538088
- Precis Future Med.
- 2022 Dec;6(4):233-242.
- doi: 10.23838/pfm.2022.00058
Purpose: Mesenchymal-epithelial transition tyrosine kinase receptor (MET) amplification is one of the common acquired resistance mechanisms to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). To evaluate the usefulness... -
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- Primary pulmonary epithelioid inflammatory myofibroblastic sarcoma: a rare entity and a literature review
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Singh P, Nambirajan A, Gaur MK, Raj R, Kumar S, Malik PS, Jain D
- KMID: 2531616
- J Pathol Transl Med.
- 2022 Jul;56(4):231-237.
- doi: 10.4132/jptm.2022.05.08
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of inflammatory myofibroblastic tumor (IMT) harboring anaplastic lymphoma kinase (ALK) gene fusions and is associated with high risk of local recurrence... -
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- Basic immunohistochemistry for lymphoma diagnosis
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Cho J
- KMID: 2529308
- Blood Res.
- 2022 Apr;57(S1):S55-S61.
- doi: 10.5045/br.2022.2022037
Immunohistochemistry is a technique that uses antigen-antibody interactions to detect specific proteins in cells. This technique has several essential applications in lymphoma diagnosis, including identifying the cell lineage and phase... -
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- A Case of Trisomy 9 Mosaicism Confirmed by Microarray Test
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Park CE, Chung ML, Hwang JH, Lee MK
- KMID: 2510275
- Kosin Med J.
- 2020 Dec;35(2):143-150.
- doi: 10.7180/kmj.2020.35.2.143
Trisomy 9 mosaicism syndrome is a rare chromosomal abnormality with a high incidence of natural abortion and perinatal death. This syndrome is characterized by intrauterine growth retardation, mental retardation, craniofacial... -
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- Screening for down syndrome using trophoblast retrieval and isolation of the cervix: preliminary study
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Lee MJ, Kim SH, Park HJ, Shim SH, Jang HY, Cha DH
- KMID: 2509987
- J Genet Med.
- 2020 Dec;17(2):68-72.
- doi: 10.5734/JGM.2020.17.2.68
Purpose: Trisomy 21, the cause of Down syndrome (DS) with various medical problems, is the most common aneuploidy during the fetal period. For diagnosis, a non-invasive screening test using maternal... -
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- The Implication of Cytogenetic Alterations in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm Identified by Fluorescence In Situ Hybridization and Their Potential Diagnostic Utility
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Lim CS, Im K, Lee DS, Kwon W, Kim JR, Han Y, Kim SW, Jang JY
- KMID: 2504208
- Gut Liver.
- 2020 Jul;14(4):509-520.
- doi: 10.5009/gnl19087
Background/Aims: We investigated chromosomal aberrations in patients with pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) by fluorescence in situ hybridization (FISH) to identify cytogenetic changes and molecular... -
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- Prevalence and Clinicopathological Significance of METOverexpression and Gene Amplification in Patients withGallbladder Carcinoma
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Kim Y, Bang SS, Jee S, Park S, Shin SJ, Jang K
- KMID: 2500333
- Cancer Res Treat.
- 2020 Apr;52(2):481-491.
- doi: 10.4143/crt.2019.370
Purpose Mesenchymal epithelial transition (MET) is a proto-oncogene that encodes a heterodimeric transmembrane receptor tyrosine kinase for the hepatocyte growth factor. Aberrant MET signaling has been described in several solid tumors—especially non-small cell... -
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- Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity
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Febres-Aldana CA, Mejia-Mejia O, Krishnamurthy K, Mesko T, Poppiti R
- KMID: 2470885
- J Breast Cancer.
- 2020 Feb;23(1):93-99.
- doi: 10.4048/jbc.2020.23.e2
Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells around small epithelial-lined spaces. Due to the rarity of adenomyoepitheliomas, the molecular data describing them are limited. Adenomyoepitheliomas are... -
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- Multistaining Optimization for Epstein-Barr Virus–Encoded RNA In Situ Hybridization and Immunohistochemistry of Formalin-Fixed Paraffin-Embedded Tissues Using an Automated Immunostainer
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Ko JN, Jung JK, Park YI, Shin HJ, Huh J, Back S, Kim YJ, Kim JH, Go H
- KMID: 2459580
- J Pathol Transl Med.
- 2019 Sep;53(5):317-326.
- doi: 10.4132/jptm.2019.08.06
BACKGROUND: Single staining is commonly performed for practical pathologic diagnoses. However, this method is limited in its ability to specify cellular morphology and immunophenotype and often requires consumption of limited... -
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- Overexpression of HER2/HER3 and clinical feature of ovarian cancer
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Chung YW, Kim S, Hong JH, Lee JK, Lee NW, Lee YS, Song JY
- KMID: 2457153
- J Gynecol Oncol.
- 2019 Sep;30(5):e75.
- doi: 10.3802/jgo.2019.30.e75
OBJECTIVES: Human epidermal growth factor receptor-2 (HER2) and 3 (HER3) belong to the epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases. In this study, we assessed HER2/HER3... -
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- Benign Gastric Ulcer with Epstein-Barr Virus Infection Mimicking Malignant Gastric Ulcer
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Gwak JW, Yoo J, Suh SO, Kim J, Oh IS, Bae JY
- KMID: 2442084
- Korean J Gastroenterol.
- 2019 Mar;73(3):177-181.
- doi: 10.4166/kjg.2019.73.3.177
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which is characterized by fever, lymphadenopathy, and sore throat. On the other hand, gastrointestinal symptoms of EBV infection like dyspepsia, abdominal... -
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- Report on the External Quality Assessment Scheme for Cytogenetics and Molecular Cytogenetics in Korea (2016–2017)
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Kim J, Shin S, Kim B, Lee ST, Kim M, Choi JR
- KMID: 2437187
- J Lab Med Qual Assur.
- 2018 Dec;40(4):188-198.
- doi: 10.15263/jlmqa.2018.40.4.188
In both 2016 and 2017, the cytogenetic and molecular cytogenetic programs conducted three assessments for the Korean Association of External Quality Assessment Service. A total of six cases with chromosomal... -
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- Clinical Implications According to Diagnostic Methods of Human Epidermal Growth Factor Receptor 2 Positivity in Breast Cancer: A Retrospective Study
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Kim BK, Jeong J, Han W, Yoon TI, Seong MK, Jung JH, Jung SH, Lee J, Sun WY, Korean Breast Cancer Society
- KMID: 2434906
- J Breast Dis.
- 2018 Dec;6(2):60-72.
- doi: 10.14449/jbd.2018.6.2.60
PURPOSE: According to American Society of Clinical Oncology/College of American Pathologists guidelines, breast cancer is human epidermal growth factor receptor 2 (HER2) positive if there is HER2 protein overexpression at... -
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- Clinicohematological parameters and outcomes in a cohort of chronic lymphocytic leukemia patients with Deletion 17p from Pakistan
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Mahmood R, Khan SA, Altaf C, Malik HS, Khadim MT
- KMID: 2429300
- Blood Res.
- 2018 Dec;53(4):276-280.
- doi: 10.5045/br.2018.53.4.276
BACKGROUND: Chronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in determining the clinical course and in predicting the... -
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- Ligand-Independent Epidermal Growth Factor Receptor Overexpression Correlates with Poor Prognosis in Colorectal Cancer
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Yun S, Kwak Y, Nam SK, Seo AN, Oh HK, Kim DW, Kang SB, Lee HS
- KMID: 2424807
- Cancer Res Treat.
- 2018 Oct;50(4):1351-1361.
- doi: 10.4143/crt.2017.487
PURPOSE: Molecular treatments targeting epidermal growth factor receptors (EGFRs) are important strategies for advanced colorectal cancer (CRC). However, clinicopathologic implications of EGFRs and EGFR ligand signaling have not been fully... -
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- Necessity of In Situ Hybridization Test of Human Epidermal Growth Factor Receptor 2 (HER2) Status in Breast Cancer Patients with Equivocal HER2 Immunohistochemistry Results
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Paik HJ, Choi HJ, Ryu JM, Park S, Kim I, Lee SK, Yu J, Kim SW, Nam SJ, Lee JE
- KMID: 2434909
- J Breast Dis.
- 2018 Jun;6(1):1-10.
- doi: 10.14449/jbd.2018.6.1.1
PURPOSE: Accurate human epidermal growth factor receptor 2 (HER2) status is important in predicting prognosis and providing treatment for HER2-positive breast cancer patients. However, performing in situ hybridization (ISH) can... -
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- Clinical Utility of a Diagnostic Approach to Detect Genetic Abnormalities in Multiple Myeloma: A Single Institution Experience
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Jung HA, Jang MA, Kim K, Kim SH
- KMID: 2403452
- Ann Lab Med.
- 2018 May;38(3):196-203.
- doi: 10.3343/alm.2018.38.3.196
BACKGROUND: The identification of genetic abnormalities in patients with multiple myeloma (MM) has gained emphasis because genetics-based risk stratification significantly affects overall survival (OS). We investigated genetic abnormalities using conventional... -
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- Anaplastic Large Cell Lymphoma with Massive Eosinophilia and Complex Karyotype Initially Misdiagnosed as Chronic Eosinophilic Leukemia
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So MK, Park S, Cho MS, Mun YC, Huh J
- KMID: 2407563
- Lab Med Online.
- 2018 Apr;8(2):56-61.
- doi: 10.3343/lmo.2018.8.2.56
We report a patient with massive eosinophilia and a complex karyotype that was initially misdiagnosed as chronic eosinophilic leukemia (CEL), but later diagnosed as anaplastic large cell lymphoma (ALCL) masked... -
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- Identification of Epstein-Barr Virus in the Human Placenta and Its Pathologic Characteristics
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Kim Y, Kim HS, Park JS, Kim CJ, Kim WH
- KMID: 2396372
- J Korean Med Sci.
- 2017 Dec;32(12):1959-1966.
- doi: 10.3346/jkms.2017.32.12.1959
Epstein-Barr virus (EBV), a common pathogen in humans, is suspected as the cause of multiple pregnancy-related pathologies including depression, preeclampsia, and stillbirth. Moreover, transmission of EBV through the placenta has... -
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- NanoString nCounter® Approach in Breast Cancer: A Comparative Analysis with Quantitative Real-Time Polymerase Chain Reaction, In Situ Hybridization, and Immunohistochemistry
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Hyeon J, Cho SY, Hong ME, Kang SY, Do I, Im YH, Cho EY
- KMID: 2438996
- J Breast Cancer.
- 2017 Sep;20(3):286-296.
- doi: 10.4048/jbc.2017.20.3.286
PURPOSE: Accurate testing for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is essential for breast cancer treatment. At present, immunohistochemistry (IHC)/florescence in situ... -
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