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In silico screening method for non‑responders to cardiac resynchronization therapy in patients with heart failure: a pilot study

Hwang M, Uhm J, Park M, Shim E, Lee C, Oh J, Yu H, Kim T, Joung B, Pak H, Kang S, Lee M

Background: Cardiac resynchronization therapy (CRT) is an effective treatment option for patients with heart failure (HF) and left ventricular (LV) dyssynchrony. However, the problem of some patients not responding to CRT...
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Cyclooxygenase-2 Inhibitor Parecoxib Was Disclosed as a PPAR-γ Agonist by In Silico and In Vitro Assay

Xiao B, Li Dd, Wang Y, Kim EL, Zhao N, Jin SW, Bai DH, Sun LD, Jung JH

In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib...
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In Silico Analysis of Potential Antidiabetic Phytochemicals from Matricaria chamomilla L. against PTP1B and Aldose Reductase for Type 2 Diabetes Mellitus and its Complications

Hariftyani AS, Kurniawati LA, Khaerunnisa S, Veterini AS, Setiawati Y, Awaluddin R

Type 2 diabetes mellitus (T2DM) and its complications are important noncommunicable diseases with high mortality rates. Protein tyrosine phosphatase 1B (PTP1B) and aldose reductase inhibitors are recently approached and advanced...
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Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma

Aditya J, A. S. Smiline G, Paramasivam A, Vijayashree PJ

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity,...
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Weak D Type 102 Found in a Family Study: The First Case in Korea

Lee B, Chung YN, Yu H, Kim TY, Choi KM, Cho D

Weak D type 102 allele (RHD*01W.102) carrying a missense variant (c.73A>T, p.Ile25Phe) in exon 1 of the RHD has not been reported in Koreans to date. This is the first...
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In-depth computational analysis of calcium-dependent protein kinase 3 of Toxoplasma gondii provides promising targets for vaccination

Majidiani H, Soltani S, Ghaffari AD, Sabaghan M, Taghipour A, Foroutan M

Purpose: The Toxoplasma gondii calcium-dependent protein kinase-3 (CDPK3) is a key enzyme for parasite egress, control of calcium-dependent permeabilization in parasitophorous vacuole membrane and tissue cyst formation. In this study,...
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BMD42-2910, a Novel Benzoxazole Derivative, Shows a Potent Anti-prion Activity and Prolongs the Mean Survival in an Animal Model of Prion Disease

Hyeon JW, Noh R, Choi J, Lee SM, Lee YS, An SSA, No KT, Lee J

Prion diseases are a group of neurodegenerative and fatal central nervous system disorders. The pathogenic mechanism involves the conversion of cellular prion protein (PrPC) to an altered scrapie isoform (PrPSc),...
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Applications of Computer Modeling and Simulation in Cartilage Tissue Engineering

Pearce D, Fischer S, Huda F, Vahdati A

Background: Advances in cartilage tissue engineering have demonstrated noteworthy potential for developing cartilage for implantation onto sites impacted by joint degeneration and injury. To supplement resource-intensive in vivo and in...
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In silico approach to calculate the transcript capacity

Lee YS, Won KH, Oh JD, Shin D

We sought the novel concept, transcript capacity (TC) and analyzed TC. Our approach to estimate TC was through an in silico method. TC refers to the capacity that a transcript...
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In silico evaluation of the acute occlusion effect of coronary artery on cardiac electrophysiology and the body surface potential map

Ryu AJ, Lee KE, Kwon SS, Shin ES, Shim EB

Body surface potential map, an electric potential distribution on the body torso surface, enables us to infer the electrical activities of the heart. Therefore, observing electric potential projected to the...
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Functional Prediction of Hypothetical Proteins from Shigella flexneri and Validation of the Predicted Models by Using ROC Curve Analysis

Gazi MA, Mahmud S, Fahim SM, Kibria MG, Palit P, Islam MR, Rashid H, Das S, Mahfuz M, Ahmeed T

Shigella spp. constitutes some of the key pathogens responsible for the global burden of diarrhoeal disease. With over 164 million reported cases per annum, shigellosis accounts for 1.1 million deaths...
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Five years of the CiPA project (2013–2018): what did we learn?

Yim DS

Cases of drug-induced QT prolongation and sudden cardiac deaths resulted in market withdrawal of many drugs and world-wide regulatory changes through accepting the ICH guidelines E14 and S7B. However, because...
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In silico analysis of putative drug and vaccine targets of the metabolic pathways of Actinobacillus pleuropneumoniae using a subtractive/comparative genomics approach

Birhanu BT, Lee SJ, Park NH, Song JB, Park SC

Actinobacillus pleuropneumoniae is a Gram-negative bacterium that resides in the respiratory tract of pigs and causes porcine respiratory disease complex, which leads to significant losses in the pig industry worldwide....
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Genetic Profiles of Korean Patients With Glucose-6-Phosphate Dehydrogenase Deficiency

Lee J, Park J, Choi H, Kim J, Kwon A, Jang W, Chae H, Kim M, Kim Y, Lee JW, Chung NG, Cho B

BACKGROUND: We describe the genetic profiles of Korean patients with glucose-6-phosphate dehydrogenase (G6PD) deficiencies and the effects of G6PD mutations on protein stability and enzyme activity on the basis of...
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In Silico Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein

Rath SN, Das D, Konkimalla VB, Pradhan SK

Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs...
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In silico analysis of Brucella abortus Omp2b and in vitro expression of SOmp2b

Golshani M, Vaeznia N, Sahmani M, Bouzari S

PURPOSE: At present, there is no vaccine available for the prevention of human brucellosis. Brucella outer membrane protein 2b (Omp2b) is a 36 kD porin existed in common Brucella pathogens...
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In silico analysis of an envelope domain III-based multivalent fusion protein as a potential dengue vaccine candidate

Fahimi H, Sadeghizadeh M, Mohammadipour M

PURPOSE: Dengue virus infection is now a global problem. Currently, there is no licensed vaccine or proven antiviral treatment against this virus. All four serotypes (1-4) of dengue virus can...
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In silico Screening of Chemical Libraries to Develop Inhibitors That Hamper the Interaction of PCSK9 with the LDL Receptor

Min DK, Lee HS, Lee N, Lee CJ, Song HJ, Yang GE, Yoon D, Park SW

PURPOSE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) and promotes degradation of the LDLR. Inhibition of PCSK9 either by reducing its expression or...
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Elucidation of the Molecular Interaction between miRNAs and the HOXA9 Gene, Involved in Acute Myeloid Leukemia, by the Assistance of Argonaute Protein through a Computational Approach

Das RP, Konkimalla VB, Rath SN, Hansa J, Jagdeb M

Acute myeloid leukemia is a well characterized blood cancer in which the unnatural growth of immature white blood cell takes place, where several genes transcription is regulated by the micro...
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SSR-Primer Generator: A Tool for Finding Simple Sequence Repeats and Designing SSR-Primers

Hong CP, Choi SR, Lim YP

  • KMID: 2053275
  • Genomics Inform.
  • 2011 Dec;9(4):189-193.
Simple sequence repeats (SSRs) are ubiquitous short tandem duplications found within eukaryotic genomes. Their length variability and abundance throughout the genome has led them to be widely used as molecular...
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