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Hydroxyurea associated ileocecal valve ulcer: evidence for causality

Jayaraman T, Rajaram RB, Gan GG, Hilmi I

Hydroxyurea is an antimetabolite drug that is commonly used in many hematological disorders. Ulcer formation in the gastrointestinal tract is a rare phenomenon associated with this drug. We report a...
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Hydroxyurea-induced Longitudinal Melanonychia: A Case Report and Dermoscopic Findings

Moon J, Park JS, Yang JH, Suh DH

  • KMID: 2436717
  • Korean J Dermatol.
  • 2018 Jun;56(5):357-359.
No abstract available.
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Clinical management of suspected intracranial meningioma in three dogs with pulsed high-dose hydroxyurea

Cho JG, Song KH, Seo KW

Three aged dogs, all over 15 years old, with multiple seizure events and various neurologic signs such as head turn and ataxia were brought to the referring hospital. Two cases...
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Cloudy urine developed during total intravenous anesthesia with 2% propofol in the patient taking hydroxyurea: A case report

Hwang BY, Kwon JY, Kim HK, Kim E, Hong S, Hong JM

We report a case that a 68-year-old man taking hydroxyurea for essential thrombocythemia produced milky urine during propofol infusion. Under microscopic analysis, the cloudy urine sample was revealed to comprise...
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The Clinical Outcome of Hydroxyurea Chemotherapy after Incomplete Resection of Atypical Meningiomas

Kim J, Kim KH, Kim YZ

BACKGROUND: The aim of this study is to investigate the clinical results of adjuvant chemotherapy with hydroxyurea and to compare those with the results of postoperative radiotherapy after incomplete resection...
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A Case of Hydroxyurea-induced Melanonychia with Mucocutaneous Hyperpigmentation

Kim SY, Jung HJ, Jung JW, Hahn HJ, Lee YW, Choe YB, Ahn KJ

  • KMID: 1802089
  • Korean J Dermatol.
  • 2014 Apr;52(4):286-287.
No abstract available.
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Hydroxyurea-induced Multiple Skin Ulcers

Byun SY, Kwon SH, Bang S, Na JI

  • KMID: 2388405
  • Korean J Dermatol.
  • 2013 Jun;51(6):480-481.
No abstract available.
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Long-Term Follow-Up Result of Hydroxyurea Chemotherapy for Recurrent Meningiomas

Kim MS, Yu DW, Jung YJ, Kim SW, Chang CH, Kim OL

OBJECTIVE: Meningiomas represent 18-20% of all intracranial tumors and have a 20-50% 10-year recurrence rate, despite aggressive surgery and irradiation. Hydroxyurea, an inhibitor of ribonucleotide reductase, is known to inhibit...
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A Hydroxyurea-induced Leg Ulcer

Hwang SW, Hong SK, Kim SH, Seo JK, Lee D, Sung HS

Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail...
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The Efficacy and Adverse Effect of Hydroxyurea as Compared with Anagrelide in Essential Thrombocythemia

Seol YM, Kwon BR, Choi YJ, Lee KW, Shin HJ, Chung JS, Lee EY, Lee WS, Joo YD, Cho GJ

BACKGROUND: Although the platelet count may not always correlate with the risk of thrombosis, there is evidence that a strict control of the platelet count decreases the incidence of thrombotic...
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Hydroxyurea Induced Perimalleolar Ulcers

Saravu K, Velappan P, Lakshmi N, Shastry BA, Thomas J

Hydroxyurea (HU) is an antineoplastic drug commonly used to treat chronic myeloproliferative disorders. Common dermatological side effects include hyperpigmentation, scaling, erythema, alopecia, desquamation of face and hands. Leg ulceration following...
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Occurence of 17p Deletion with Blast Transformation in Idiopathic Myelofibrosis Treated with Hydroxyurea

Ha JS, Ryoo NH, Kim JR, Jeon DS

  • KMID: 1637298
  • Korean J Hematol.
  • 2004 Mar;39(1):46-50.
The recently described '17p deletion syndrome' is a clonal hematologic disease which has characteristic dysgranulopoietic features, such as pseudo-Pelger-Huet hypogranulation and small vacuoles in neutrophils and is strongly associated with...
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Treatment of Childhood Essential Thrombocythemia with Hydroxyurea

Kim JY, Lee KS

  • KMID: 1637296
  • Korean J Hematol.
  • 2004 Mar;39(1):36-41.
BACKGROUND: Essential thrombocythemia (ET) in children is a rare chronic myeloproliferative disorder characterized by a sustained proliferation of megakaryocytes, which leads to increased numbers of circulating platelets. Major complications are...
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Involvement of mitogen-activated protein kinases and p21Waf1 in hydroxyurea-induced G1 arrest and senescence of McA-RH7777 rat hepatoma cell line

Hong SH, Hong BS, Kim DC, Rho MS, Park JI, Rha SH, Jun HS, Jeong JS

  • KMID: 1123771
  • Exp Mol Med.
  • 2004 Oct;36(5):493-498.
Hydroxyurea is commonly used to treat hematologic disorders and some type of solid tumors, but the mechanism for its therapeutic effect is not clearly known. In this study, we examined...
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A Case of Cutaneous Manifestations Associated With Hydroxyurea Therapy

Jang SJ, Moon YJ, Choi YH, Kim JH, Won JY

  • KMID: 2086696
  • Korean J Dermatol.
  • 2003 Jul;41(7):965-967.
Hydroxyurea is an antitumor agent that has attained an important role in the management of myeloproliferative syndromes. Its mechanism of action is not fully understood, but it appears to affect...
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Cerebral Infarction in Essential Thrombocythemia after Discontinuation of Hydroxyurea

Kim JM, Cho EK, Han YS, Han JH, Kim DE

  • KMID: 2338255
  • J Korean Geriatr Soc.
  • 2003 Jun;7(2):159-163.
Abnormalities in the number and function of platelets may contribute to thromboembolic complications in patients with essential thrombocythemia(ET). Physicians often use hydroxyurea which reduces the platelet count for the initial...
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A Case of Idiopathic Hypereosinophilic Syndrome Treated Successfully with Hydroxyurea and Interferon alpha-2b

Yang GH, Park EY, Jung HL, Kim DS, Shim JW, Shim JY, Park MS

  • KMID: 2278303
  • Korean J Pediatr Hematol Oncol.
  • 2003 Oct;10(2):269-276.
The idiopathic hypereosinophilic syndromes are rare hematologic disorders showing a wide spectrum of diseases with eosinophilia and associated organ damage. Three criteria for diagnosis include persistent eosinophilia of at least...
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A case of Hydroxyurea-induced fever

Lee G, Kang HJ, Oh HA, Choi JH, Lee JL, Lee KH, Hyun MS, Ryu HM

  • KMID: 1866923
  • Korean J Med.
  • 2002 May;62(5):581-583.
A patient with idiopathic hypereosinophilic syndrome is reported who developed a drug fever that may be related to the administration of hydroxyurea. Typically, this form of fever develops after a...
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A Case of Hydroxyurea-Induced Cutaneous Ulceration and Squamous Cell Carcinoma

Yun SJ, Lee JB, Kim SJ, Lee SC, Won YH

  • KMID: 1604675
  • Korean J Dermatol.
  • 2002 Apr;40(4):433-436.
Hydroxyurea, one of conventional chemotherapies in chronic myelogenous leukemia(CML) and polycythemia vera, inhibits ribonucleotide reductase, which catalyzes the rate-limiting step in the de novo synthesis of deoxynucleotide triphosphates required for...
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Chronic Hydroxyurea-induced Dermatomyositis-like Eruption Showing Epidermal Dysmaturation

Park JH, Kim CD, Ryoo YW, Kim BC, Lee KS

Hydroxyurea is an effective treatment for a variety of myeloproliferative disodrers. A distinct cutaneous reaction to long-term administration of hydroxyurea has been characterized and designated hydroxyurea dermopathy. Epidermal dysmaturation refers...
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