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Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock

Mitaka C, Kusaoi M, Kawagoe I, Satoh D

Endotoxin adsorption therapy by polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) has been used for the treatment of septic shock patients. Endotoxin, an outer membrane component of Gram-negative bacteria, plays...
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Initial Experience of Using Polymyxin B Hemoperfusion in Abdominal Septic Shock: Things to Consider for Better Outcome

Park YJ, Kim EY

Purpose: Polymyxin B hemoperfusion (which treats septic shock by removing endotoxins of gram-negative bacteria), has been proposed as a treatment modality for intraabdominal sepsis. However, there are few studies about...
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A successful application of adult polymyxin B-immobilized fiber column hemoperfusion to a neonate with septic shock

Kim YA, Kim H, Kim YM, Park SE

Direct hemoperfusion therapy with a polymyxin B-immobilized fiber column (PMX-HP) has been introduced as a therapeutic option for gram negative bacterial septic shock in adults. However, its use in neonates...
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Use of Polymyxin B Hemoperfusion in a Patient with Septic Shock and Septic Cardiomyopathy Who Was Placed on Extracorporeal Membrane Oxygen Support

Shin SH, Lee H, Choi AJ, Chang KH, Suh GY, Chung CR

Although shock in sepsis is usually managed successfully by conventional medical treatment, a subset of cases do not respond and may require salvage therapies such as veno-arterial extracorporeal membrane oxygenation...
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Refractory Septic Shock Treated with Nephrectomy under the Support of Extracorporeal Membrane Oxygenation

Lee YK, Ryu JA, Yang JH, Park CM, Suh GY, Jeon K, Chung CR

Conventional medical therapies have not been very successful in treating adults with refractory septic shock. The effects of direct hemoperfusion using polymyxin B and veno-arterial extracorporeal membrane oxygenation (ECMO) for...
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Polymyxin B Hemoperfusion in Pneumonic Septic Shock Caused by Gram-Negative Bacteria

Yoo JW, Park SY, Jeon J, Huh JW, Lim CM, Koh Y, Hong SB

Severe sepsis and septic shock are the main causes of death in critically ill patients. Early detection and appropriate treatment according to guidelines are crucial for achieving favorable outcomes. Endotoxin...
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Polymyxin B Immobilized Fiber Hemoperfusion in Refractory Intra-abdominal Septic Shock

Chang HW, Cho YJ, Park SH, Kim M

The effects of direct hemoperfusion with polymyxin B immobilized fiber (PMX) treatment for septic shock have been recently reported. However, little evidence of a true benefit on clinical outcomes, including...
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A Case of Life-Threatening Supraventricular Tachycardia Related to Flecainide Toxicity

Cheon SS, Song JH, Bae MH, Lee JH, Yang DH, Park HS, Chae SC

  • KMID: 2269266
  • Korean J Med.
  • 2014 Jul;87(1):72-76.
Flecainide acetate is a potent class Ic anti-arrhythmic drug with a major sodium channel-blocking effect. Flecainide toxicity can cause myocardial impairment and precipitate circulatory collapse, particularly in patients with renal...
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Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication

Gil HW, Hong JR, Jang SH, Hong SY

Paraquat (PQ) has known negative human health effects, but continues to be commonly used worldwide as a herbicide. Our clinical data shows that the main prognostic factor is the time...
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Usefulness of Hemoperfusion in Paraquat Poisoning

Choi WS, Jung EH, Park EH, Seo JY, Jun KH, Kang MS, Kim H

  • KMID: 2258998
  • Korean J Med.
  • 2011 Mar;80(3):308-316.
BACKGROUND/AIMS: Paraquat is a potentially lethal herbicide that induces acute renal failure, hepatic dysfunction, and progressive respiratory failure. This study examined the usefulness of hemoperfusion in paraquat poisoning. METHODS: We reviewed...
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Prognostic Factors and the Effect of Hemoperfusion for Patients with Paraquat Poisoning

Sung AJ, Jang JY

BACKGROUND: Paraquat has been widely used as a non-selective contact herbicide and it may induce damage to many organs. This study aimed to assess the factors that can predict the...
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A Case of Successful Management of Paraquat Poisoning with Severe Pulmonary Fibrosis

Min JH, Lee JA, Choi WS, Kim H, Kang MS, Jun KH, Jung WM

  • KMID: 2192634
  • J Korean Soc Emerg Med.
  • 2009 Dec;20(6):732-737.
Paraquat, a potent herbicide, has caused many fatalities through indiscriminate use and suicides. With ingestion of more than one mouthful of 20% paraquat, death is usually caused by pulmonary fibrosis....
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A Case of Successful Hemoperfusion in the Treatment of Acute Severe Clozapine Intoxication

Kim HJ, Kim SJ, Lee KH, Gil HW, Yang JO, Lee EY, Hong SY

  • KMID: 2307175
  • Korean J Nephrol.
  • 2009 Nov;28(6):639-642.
Clozapine, a psychotropic drug commonly used in the treatment of schizophrenia or schizophrenic affective disorders may show side effects such as agranulocytosis, cardiomyositis, cognitive and motor depression in therapeutic doses...
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Comparison between Kidney and Hemoperfusion for Paraquat Elimination

Kang MS, Gil HW, Yang JO, Lee EY, Hong SY

The mortality rate of acute paraquat (PQ) poisoning depends on the PQ concentration in the blood. It has been shown that the kidneys eliminate PQ effectively. However, early renal function...
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Successful Hemoperfusion in Acute Phenobarbital Intoxication

Kim DH, Kim DK, Park JH, Hong YK, Oh HS, Jung YH, Gil HW, Yang JO, Lee EY, Hong SY

  • KMID: 2079596
  • Korean J Nephrol.
  • 2006 Jan;25(1):165-168.
Phenobarbital is long acting barbiturate with low lipid solubility that act as central nervous system depressants and used as anticonvulsant, sedative, hypnotic drug. In acute severe barbiturate intoxication, through CNS...
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A Case of Acute Theophylline Intoxication Treated with Hemoperfusion

Lee JH, Oh WS, Park SW, Ryu ST, Kim KW

  • KMID: 2307251
  • Korean J Nephrol.
  • 2005 Sep;24(5):860-863.
Theophylline has been used for more than 50 years to treat bronchial asthma, and theophylline toxicity continues to be an encountered clinical problem. With suicidal intention, a 61-year-old depressive male...
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Efficacy of Extracorporeal Extraction Treatment in Paraquat Poisoning

Lee DR, Kim GT

  • KMID: 2193884
  • J Korean Soc Emerg Med.
  • 2004 Aug;15(4):273-279.
PURPOSE: The value of extracorporeal extraction in treating paraquat poisoning was questioned; some saved their patients by applying hemoperfusion, but others failed. This study was designed to investigate the efficacy...
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A Case of Paraquat Intoxication Caused by Intramuscular Injection

Lim SW, Lee WY, Han HS, Hahn JS, Kim MO, Kwon SK, Kim HY, Shin KS

  • KMID: 2079412
  • Korean J Nephrol.
  • 2004 May;23(3):505-508.
Paraquat intoxication is a fatal problem. Most of paraquat intoxications happen through oral administration. But there is no clinical data for parenteral paraquat intoxication, so we will describe its fatal...
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Hemodynamic Changes during Isolated Liver Hemoperfusion of Hepatoma

Ha SJ, Hwang YJ, Lim DG

  • KMID: 2228518
  • Korean J Crit Care Med.
  • 2004 Dec;19(2):115-120.
BACKGROUND: To analyze hemodynamic changes during single catheter technique of hepatic venous isolation and extracorporeal charcoal hemoperfusion for malignant liver tumor. METHODS: Drugs for chemotherapy were infused to the liver...
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A life-threatening case of acute valproic acid overdose treated successfully with serial hemoperfusion and hemodialysis

Park JH, Park JS, Park MY, Joo HS, Yang JO, Lee EY, Hong SY

  • KMID: 2306014
  • Korean J Med.
  • 2004 Oct;67(4):404-408.
Valproic acid is available as an antiepileptic therapy and has been used treat bipolar disorder and migraine headaches. In the setting of accidental or intentional ingestion of valproic acid overdose,...
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