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Role of Post-Treatment 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients Receiving Definitive Chemoradiation for Locally Advanced Head and Neck Squamous Cell Carcinomas

Kim JJ, Oh SB, Jung KS, Park K, Kim SJ, Ki Y, Lee JC, Oh SY

Background and Objectives 18F-fluorodeoxyglucose PET/CT scans can be a useful method to detect recurrence. However, its role in locally advanced head and neck squamous cell carcinomas (HNSCCs) patients after definitive...
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Development and Validation of a Model Using Radiomics Features from an Apparent Diffusion Coefficient Map to Diagnose Local Tumor Recurrence in Patients Treated for Head and Neck Squamous Cell Carcinoma

Kim M, Lee JH, Joo L, Jeong B, Kim S, Ham S, Yun J, Kim N, Chung SR, Choi YJ, Baek JH, Lee JY, Kim Jh

Objective: To develop and validate a model using radiomics features from apparent diffusion coefficient (ADC) map to diagnose local tumor recurrence in head and neck squamous cell carcinoma (HNSCC). Materials and...
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Frequency of PIK3CA mutations in different subsites of head and neck squamous cell carcinoma in southern Thailand

Dechaphunkul A, Thongwatchara P, Thongsuksai P, Dechaphunkul T, Geater SL

Background: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations have been reported in many cancers, including head and neck squamous cell carcinoma (HNSCC). The frequency of these mutations varies among tumor...
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Induction Chemotherapy as a Prognostication Index and Guidance for Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: The Concept of Chemo-Selection (KCSG HN13-01)

Lee YG, Kang EJ, Keam B, Choi JH, Kim JS, Park KU, Lee KE, Kim HJ, Lee KW, Kim MK, Ahn HK, Shin SH, Kim HR, Kim SB, Yun HJ

Purpose Certain patient subgroups who do not respond to induction chemotherapy (IC) show inherent chemoresistance in locally advanced head and neck squamous cell carcinoma (LA-HNSCC). This study aimed to assess...
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Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma

Aditya J, A. S. Smiline G, Paramasivam A, Vijayashree PJ

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity,...
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Gene signature for prediction of radiosensitivity in human papillomavirus-negative head and neck squamous cell carcinoma

Kim SI, Kang JW, Noh JK, Jung HR, Lee YC, Lee JW, Kong M, Eun YG

Purpose: The probability of recurrence of cancer after adjuvant or definitive radiotherapy in patients with human papillomavirus-negative (HPV(–)) head and neck squamous cell carcinoma (HNSCC) varies for each patient. This...
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Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma

Dai L, Fang Q, Li P, Wu J, Zhang X

Purpose The main goal of this study was to analyze the prognosis of secondary oral squamous cell carcinoma (SCC) with a comparison with sporadic oral SCC by a matched-pair design. Materials and...
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Current Development and Research Trend of Chemotherapeutic Agents for Head and Neck Squamous Cell Carcinoma

Lee YS

After FDA approval of cetuximab at 2006, receptor tyrosine kinase, including an epidermal growth factor receptor, blocking agents have been evaluated for head and neck squamous cell carcinoma (HNSCC). Agents...
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Human Papillomavirus Serologic Profiles of Selected Filipinos with Head and Neck Squamous Cell Carcinoma

Albano PM, Salvador C, Orosa J, Racelis S, Leaño M, Michel A, Ramos JD, Holzinger , Pawlita M

BACKGROUND: The low prevalence of human papillomavirus (HPV) DNA and mRNA in biopsy samples of Filipinos with head and neck squamous cell carcinoma (HNSCC) has been reported previously. Here, the...
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Investigating Trk Protein Expression between Oropharyngeal and Non-oropharyngeal Squamous Cell Carcinoma: Clinical Implications and Possible Roles of Human Papillomavirus Infection

Cho YA, Chung JM, Ryu H, Kim EK, Cho BC, Yoon SO

PURPOSE: The relationship between head and neck squamous cell carcinoma (HNSCC) and subtypes of tropomyosin-related kinase (Trk) has not been studied in-depth. In this study, we evaluated the expression patterns...
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Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same

Sahu V, Nigam L, Agnihotri , Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S

PURPOSE: The p38 mitogen-activated protein kinase (MAPKs) play a crucial role in the production of pro-inflammatory cytokines and over-expression of it increase cytokines which promote cancer. Among four isoforms, p38α...
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Changes in Oral Microbiota in Patients Receiving Radical Concurrent Chemoradiotherapy for The Head and Neck Squamous Cell Carcinoma

Kim JH, Choi YH, An SY, Son HY, Choi C, Kim S, Chung J, Na HS

Radiotherapy (RT) is a mainstay in the treatment of head and neck squamous cell carcinoma (HNSCC). For locally advanced HCSCC, concurrent chemoradiotherapy (CCRT) benefits HCSCC patients in terms of better...
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Molecular Targeted Therapy of Head and Neck Cancer: Promising Molecular Targets of Post-Epidermal Growth Factor Receptor Era

Chang JW, Kim CH

Head and neck squamous cell carcinoma (HNSCC) affects over half a million people worldwide. Despite advances in biology and medicine, only half of the patients are alive in 5 years....
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Chemotherapy of Head and Neck Cancer

Yeo CK

Head and neck cancers comprise a heterogenous group of cancers that require a multidisciplinary approach. Surgery, radiation therapy, chemotherapy and, more recently, target therapy are often employed in various combinations...
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Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma

Kim DY, Roh JL, Choi JW, Choi SH, Nam SY, Kim SY

  • KMID: 2278401
  • Clin Exp Otorhinolaryngol.
  • 2014 Mar;7(1):36-41.
OBJECTIVES: This study evaluated the risk factors for anastomotic leakage (AL) and survival outcomes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Patients with HNSCC who underwent surgery...
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FDG-PET/CT as prognostic factor and surveillance tool for postoperative radiation recurrence in locally advanced head and neck cancer

Kim G, Kim YS, Han EJ, Yoo IR, Song JH, Lee SN, Lee JH, Choi BO, Jang HS, Yoon SC

PURPOSE: To evaluate the prognostic value of metabolic tumor volume (MTV) and maximum standardized uptake value (SUVmax) on initial positron emission tomography-computed tomography (PET-CT) and investigate the clinical value of...
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Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi KH, Yoo IR, Han EJ, Kim YS, Kim GW, Na SJ, Sun DI, Jung SL, Jung CK, Kim MS, Lee SY, Kim SH

  • KMID: 2051993
  • Nucl Med Mol Imaging.
  • 2011 Mar;45(1):43-51.
PURPOSE: We assessed the prognostic value of metabolic tumor volume (MTV) measured using 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma...
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Growth Inhibition of Human Head and Neck Squamous Cell Carcinomas by Angelica decursiva Extracts

Shin WC, Kim CS, Kim HJ, Lee MH, Kim HR, Kim DK

  • KMID: 1457207
  • Int J Oral Biol.
  • 2010 Dec;35(4):153-158.
Angelica decursiva has been used in Korean traditional medicine as an antitussive, an analgesic, an antipyretic and a cough remedy. However, the anti-cancer properties of Angelica decursiva have not yet...
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The Usability of p16 Immunohistochemical Staining as a Screening Test of Human Papillomavirus Infection in Head and Neck Squamous Cell Carcinoma

Kwon MO, Kim SH, Hwang JY, Lee SY

BACKGROUND AND OBJECTIVES: Although human papillomavirus (HPV) infection has been recognized as having an important role in the pathogenesis of head and neck squamous cell carcinoma (HNSCC), there is no...
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Expression of GLUT-1 and EGFR in Head and Neck Squamous Cell Carcinoma

Lee JE, Jung YH, Chung JH, Ahn SH

BACKGROUND AND OBJECTIVES: We investigated the expression of glucose uptake transporter-1 (GLUT-1) and epidermal growth factor receptor (EGFR) in the head and neck squamous cell cancer (HNSCC) and their influence...
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