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All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells

Kim Y, Jeung HK, Cheong JW, Song J, Bae SH, Lee JI, Min YH

Purpose: Pharmacological inhibition of mutant isocitrate dehydrogenase (IDH) reduces R-2-hydroxyglutarate (2-HG) levels and restores cellular differentiation in vivo and in vitro. The IDH2 inhibitor enasidenib (AG-221) has been approved by...
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Treatment Outcomes of Combination Therapy with 1,064-nm Neodymium-doped Yttrium Aluminum Garnet Laser and Efinaconazole 10% Solution for Big Toenail Onychomycosis: a Retrospective Study

Suh DH, Park HJ, Lee SJ, Kim H, Jeong KH, Lee MH, Shin MK

BACKGROUND: Laser therapy can be used as an alternative treatment for onychomycosis; however, there are some limitations to its efficacy as a single agent. OBJECTIVE: To evaluate the effectiveness of combination therapy...
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Combined blockade of HER2 and VEGF exerts greater growth inhibition of HER2-overexpressing gastric cancer xenografts than individual blockade

Singh R, Kim WJ, Kim PH, Hong HJ

  • KMID: 2154271
  • Exp Mol Med.
  • 2013 Nov;45(11):e52.
Gastric cancer overexpressing the human epidermal growth factor 2 (HER2) protein has a poor outcome, although a combination of chemotherapy and the anti-HER2 antibody trastuzumab has been approved for the...
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Scheduled Interval Trans-Catheter Arterial Chemoembolization Followed by Radiation Therapy in Patients with Unresectable Hepatocellular Carcinoma

Yu JI, Park HC, Lim DH, Kim CJ, Oh D, Yoo BC, Paik SW, Kho KC, Lee JH

Combination treatment of trans-catheter arterial chemoembolization (TACE) and conformal radiation therapy (RT) reported promising results in patients with hepatocellular carcinoma (HCC), but, optimal interval was not determined. We hypothesized that...
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Combination Treatment for Choroidal Neovascularization Associated With Large Retinal Pigment Epithelial Detachment

Ryu JW, Jung JH, Lee WK

PURPOSE: To evaluate the efficacy of the combination therapy of intravitreal bevacizumab injection and photodynamic therapy in neovascular age-related macular degeneration associated with large retinal pigment epithelial detachment. METHODS: A total...
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Hepatotoxicity of Combination Treatment with Leflunomide and Methotrexate in RA Patients

Chang JH, Jung ES, Lee JH, Yoon BY, Lee CH, Lee YW

OBJECTIVE: Leflunomide is the newest disease-modifying anti-rheumatic drug (DMARD) that is known to have an equivalent clinical efficacy and tolerability to methotrexate (MTX). Previous studies reported that a co-treatment with...
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Experience of Combination Treatment of Toenail Onychomycosis with Oral Itraconazole and Topical 5% Amorolfine Nail Lacquer

Yoon YH, An JY, Ro BI

  • KMID: 1517350
  • Korean J Med Mycol.
  • 2004 Sep;9(3):159-165.
BACKGROUND: Target of oral itraconazole is nail matrix via nail bed diffusion. On the contrary, topical amorolfine directly acts on nail plate through a transungual drug delivery system. When this...
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Treatment of Gonorrhea with Antibiotic Combination Regimens - Kanamycin plus Benzyl Penicillin G / Probenecid versus Kanamycin plus Trimethoprim-Sulfamethoxazole

Whang KU, Kim JH, Kim JH

  • KMID: 2231555
  • Korean J Dermatol.
  • 1986 Oct;24(5):623-630.
From August to November 1985 244 bacteriologically proven male uncomplirated goncicoccal urethritis patients at the VD clinic of Choong-Ku Public Health Center form August to November 1985 were divided into...
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