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A Case of Chlorpromazine-Induced Skin Pigmentation and Ophthalmic Lesions

Ryoo YW, Yun JM, Kim HW, Kim SA

  • KMID: 2530089
  • Korean J Dermatol.
  • 2022 May;60(4):272-274.
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Chlorpromazine-induced Exfoliative Photoallergic Reaction

Kim YH, Lee GB

  • KMID: 2508346
  • J Korean Soc Biol Ther Psychiatry.
  • 2020 Oct;26(3):269-273.
Despite the availability of second-generation antipsychotic drugs, chlorpromazine is still commonly used in Korea and many other countries due to its cost effectiveness, particularly for patients experiencing psychomotor excitement. Adverse...
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Prolonged Low-dose Chlorpromazine Therapy Induced Skin Pigmentation and Corneal and Lens Opacities

Park B, Park JY, JANG Y, Cho EB, Park EJ, Kim KH, Kim KJ

  • KMID: 2437007
  • Korean J Dermatol.
  • 2018 Nov;56(9):575-577.
No abstract available.
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Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats

Dejanovic , Stevanovic I, Ninkovic M, Stojanovic I, Lavrnja I, Radicevic , Pavlovic M

This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen...
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Blue-gray Pigmentation Induced by Chlorpromazine

Chun SW, Lee SY, Son HO, Lee SY, Cho HK, Ro BI, Choi HG

  • KMID: 2245859
  • Korean J Dermatol.
  • 2015 Sep;53(8):659-661.
No abstract available.
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Chlorpromazine activates p21(Waf1/Cip1) gene transcription via early growth response-1 (Egr-1) in C6 glioma cells

Shin SY, Kim CG, Kim SH, Kim YS, Lim Y, Lee YH

2-Chloro-10-[3(-dimethylamino)propyl]phenothiazinemonohydrochloride (chlorpromazine) is a phenothiazine derivative used clinically to control psychotic disorders. It also exhibits an anticancer activity. Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase...
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A Clinical Analysis of Hiccup Patients who Visited the Emergency Department

Park JS, Kim H, Lee SW, Oh SK, Lee BG

  • KMID: 2332585
  • J Korean Soc Emerg Med.
  • 2008 Dec;19(6):743-748.
PURPOSE: There have been few studies concerned with the hiccup patients who visit the emergency department. The purpose of this study is to investigate the epidemiology and clinical characteristics of...
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Probable Case of Neuroleptic Malignant Syndrome Following Administration of Antituberculotic Drugs in a Chlorpromazine-Treated Patient

Shim G, Kang DH, Kwon JS

Neuroleptic malignant syndrome (NMS), a potentially fatal adverse reaction to neuroleptics, is known to occur more often in the initial stage of antipsychotic treatment. We describe a patient with chronic...
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A Case of Persistent Hiccup in a Patient with Non-small Cell Lung Cancer

Park HS, Sim YS, Lim SY, Jo JY, Kwon SS, Roh SH, Kim YR, Chun EM, Lee JH, Ryu YJ, Song DE, Moon JW

A hiccup is caused by involuntary, intermittent, and spasmodic contractions of the diaphragm and intercostal muscles. It starts with a sudden inspiration and ends with an abrupt closure of the...
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A Case of Tardive Blepharospasm

Woo SR, Jeong SY, Lim ES, Jeong SK, Seo MW

  • KMID: 2185364
  • J Korean Neurol Assoc.
  • 2005 Aug;23(4):565-567.
Blepharospasm is a focal dystonia that consists of repetitive involuntary spasmodic contractions of the orbicularis oculi muscle. A 27-year-old man was admitted with ptosis and involuntary blinking in both eyes....
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Erectile Response of Intracavernous Injection of New Triple Agents, Chlorpromazine, Papaverine, and Alprostadil

Lee YS, Kim SC

  • KMID: 2293569
  • Korean J Urol.
  • 2003 Nov;44(11):1121-1123.
PURPOSE: This study was aimed to compare the erectile response when phentolamine of intracavernous trimix(papaverine, phentolamine, alprostadil) was replaced with chlorpromazine. MATERIALS AND METHODS: A total of 65 patients with erectile...
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A case of fever of unknown origin after removal of hypothalamic tumor

Park JH, Yu HS, Go JS, Bae WG, Shin J, Kim SJ, Shin DH

  • KMID: 2252776
  • Korean J Med.
  • 2003 Nov;65(Suppl 3):S894-S897.
The preoptic area and anterior hypothalamus plays a pivotal role in body temperature regulation, and damage in this region causes hyperthermia. This hyperthermia is particularly troublesome because of the possibility...
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The Protective Effect of Chlorpromazine on Flurothyl-Induced Seizure

Kim DW

  • KMID: 2007390
  • J Korean Child Neurol Soc.
  • 2003 Nov;11(2):234-237.
PURPOSE: Chlorpromazine(CPZ) is known to inhibit glutamate ehydrogenase(GDH). Reductive amination of alpha-ketoglutarate is catalyzed by GDH and forms glutamate, a major excitatory neurotransmitter. Thus, I hypothesized that CPZ might have...
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The Protective Effect of Chlorpromazine on Pentylenetetrazole Induced Seizure

Kim EA, Kim DW, Chae SA

  • KMID: 2329287
  • J Korean Child Neurol Soc.
  • 2003 May;11(1):20-23.
PURPOSE: Chlorpromazine(CPZ) is known to inhibit glutamate dehydrogenase(GDH). Reductive amination of alpha-ketoglutarate is catalyzed by GDH and forms glutamate, a major excitatory neurotransmitter. Thus, we hypothesized that CPZ might have...
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Two Cases of Chlorpromazine-induced Corneal and Lenticular Opacity

Kim HS, Choi HJ, Yun YS

  • KMID: 2125268
  • J Korean Ophthalmol Soc.
  • 2002 Nov;43(11):2349-2353.
PURPOSE: To report two cases of corneal deposits and anterior capsular opacity after prolonged chlorpromazine therapy METHODS: Two schizophrenic patients using chlorpromazine showed the corneal endothelial opacity and anterior capsular opacity....
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Genetic Safety Study of Chlorpromazine

Kim HG, Shon YH, Lee KH, Yoon TH, Nam KS

  • KMID: 2340464
  • J Korean Neuropsychiatr Assoc.
  • 2000 May;39(3):629-637.
OBJECT: The aim of this study is to determine whether exposure to chlorpromazine causes mutagenicity and genetic disorders. METHOD: Ames (Salmonella typhimurium) test and Rec assay (Bacillus subtilis) were used as...
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Electroencephalographic effects of chlorpromazine in rats

Yun JE, Lee MG

  • KMID: 2285218
  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):245-250.
The effects of an antipsychotic, chlorpromazine, on the electroencephalogram (EEG) were observed while rats were awake but immobile. The time course and the dose-dependency of the EEG changes were examined. The method of...
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Effects of Nemonapride on Cognitive and Psychomotor Performance and Sedation in Normal Adults: A Comparison with Chlorpromazine, Haloperidol and Placebo

Yoon BH, Yoon JS, Park SW

  • KMID: 1985338
  • Korean J Psychopharmacol.
  • 1998 Oct;9(2):119-130.
This study was done to compare the effects of nemonapride on cognitive and psychomotor performance and sedation with those of classical antipsychotics in normal adults. Single doses of three antipsychotics...
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Stress Among Chinese, Korean-Chinese and Korean High School Students: A Transcultural Study

Jeong SH, Kim SW, Kang UG, Jeon SH, Joo YH, Park JB, Kim YS

  • KMID: 2340048
  • J Korean Neuropsychiatr Assoc.
  • 1997 Mar;36(2):368-375.
OBJECT: In order to examine the interaction mechanisms of electroconvulsive shock(ECS) and antipsychotic drug at the level of molecular biology, we observed the effect of chlorpromazine pre-treatment on the activation...
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NEUROLEPTIC MALIGNANT SYNDROME-LIKE STATE DUE TO DEPOT OF CHLORPROMAZINE: A Case Report

Jin YH, Lee JB

  • KMID: 1540242
  • J Korean Soc Emerg Med.
  • 1997 Mar;8(1):98-102.
The neuroleptic malignant syndrome(NMS) results primarily from an imbalance of central neurotransmitters and typically occurs after acute or chronic neuroleptic drug use rather than after neuroleptic overdosage. It is a...
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