- Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling
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Shakya R, Park GH, Joo SH, Shim JH, Choi JS
- KMID: 2534709
- Biomol Ther.
- 2022 Nov;30(6):585-592.
- doi: 10.4062/biomolther.2022.121
Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist... -
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- Synthetic Homoisoflavane Derivatives of Cremastranone Suppress Growth of Colorectal Cancer Cells through Cell Cycle Arrest and Induction of Apoptosis
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Shin HE, Lee S, Choi Y, Park S, Kwon S, Choi JK, Seo SY, Lee Y
- KMID: 2534708
- Biomol Ther.
- 2022 Nov;30(6):576-584.
- doi: 10.4062/biomolther.2022.090
Colorectal cancer is diagnosed as the third most prevalent cancer; thus, effective therapeutic agents are urgently required. In this study, we synthesized six homoisoflavane derivatives of cremastranone and investigated their... -
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- Triphenyl phosphate activates estrogen receptor α/NF-κB/ cyclin D1 signaling to stimulate cell cycle progression in human Ishikawa endometrial cancer cells
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Kwon HY, Park SB, Han M, Park JW, Lee Y, Han Sj, Kwon Y, Cho YJ
- KMID: 2535961
- Obstet Gynecol Sci.
- 2022 Nov;65(6):531-541.
- doi: 10.5468/ogs.22108
Objective Triphenyl phosphate (TPHP) is one of the most commonly used organophosphorus flame retardants that may accumulate in the environment. However, its effects on human reproductive organs have not been well... -
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- PLK2 Single Nucleotide Variant in Gastric Cancer Patients Affects miR-23b-5p Binding
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Dominkuš PP, Mesic A, Hudler P
- KMID: 2535112
- J Gastric Cancer.
- 2022 Oct;22(4):348-368.
- doi: 10.5230/jgc.2022.22.e31
Purpose: Chromosomal instability is a hallmark of gastric cancer (GC). It can be driven by single nucleotide variants (SNVs) in cell cycle genes. We investigated the associations between SNVs in... -
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- Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer
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Seo HR, Nam AR, Bang JH, Oh KS, Kim JM, Yoon J, Kim TY, Oh DY
- KMID: 2528223
- Cancer Res Treat.
- 2022 Apr;54(2):541-553.
- doi: 10.4143/crt.2021.473
Purpose Up to 20% of patients with biliary tract cancer (BTC) have alterations in DNA damage response (DDR) genes, including homologous recombination (HR) genes. Therefore, the DDR pathway could be... -
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- Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway
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Ko EB, Jang YG, Kim CW, Go RE, Lee HK, Choi KC
- KMID: 2526817
- Biomol Ther.
- 2022 Mar;30(2):151-161.
- doi: 10.4062/biomolther.2021.074
This study elucidates the anti-cancer potential of gallic acid (GA) as a promising therapeutic agent that exerts its effect by regulating the PI3K/Akt pathway. To prove our research rationale, we... -
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- Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling
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Lee SO, Joo SH, Kwak AW, Lee MH, Seo JH, Cho SS, Yoon G, Chae JI, Shim JH
- KMID: 2522254
- Biomol Ther.
- 2021 Nov;29(6):658-666.
- doi: 10.4062/biomolther.2021.143
Podophyllotoxin (PT), a lignan compound from the roots and rhizomes of Podophyllum peltatum, has diverse pharmacological activities including anticancer effect in several types of cancer. The molecular mechanism of the... -
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- Effect and mechanism of chitosan-based nano-controlled release system on the promotion of cell cycle progression gene expression
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Lee WJ, Park KM, Lee Rs, Hwang YJ, Lee SW
- KMID: 2521832
- J Korean Acad Prosthodont.
- 2021 Oct;59(4):379-394.
- doi: 10.4047/jkap.2021.59.4.379
Purpose In our previous studies, application of trichloroacetic acid (TCA) to gingival fibroblasts or to canine palatal soft tissue was verified to alter the expression of several genes responsible for... -
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- Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers
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Jiang X, Jiang Y, Luo S, Sekar K, Koh CKT, Deivasigamani A, Dong Q, Zhang N, Li S, Hao F, Goh BKP, Ooi LL, Wang Y, Hui KM
- KMID: 2521571
- Cancer Res Treat.
- 2021 Oct;53(4):944-961.
- doi: 10.4143/crt.2020.466
Purpose NUF2 has been implicated in multiple cancers recently, suggesting NUF2 may play a role in the common tumorigenesis process. In this study, we aim to perform comprehensive meta-analysis of... -
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- Role of IFNLR1 gene in PRRSV infection of PAM cells
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Qin M, Chen W, Li Z, Wang L, Ma L, Geng J, Zhang Y, Zhao J, Zeng Y
- KMID: 2516200
- J Vet Sci.
- 2021 May;22(3):e39.
- doi: 10.4142/jvs.2021.22.e39
Background: Interferon lambda receptor 1 (IFNLR1) is a type II cytokine receptor that clings to interleukins IL-28A, IL29B, and IL-29 referred to as type III IFNs (IFN-λs). IFN-λs act through... -
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- Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells
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Park JA, Park S, Choi JK, Han MK, Lee Y
- KMID: 2515994
- Int J Stem Cells.
- 2021 May;14(2):180-190.
- doi: 10.15283/ijsc20089v
Background and Objectives: Embryonic stem (ES) cells have the capacity to self-renew and generate all types of cells. MUC1-C, a cytoplasmic subunit of MUC1, is overexpressed in various carcinomas and mediates... -
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- Biomarker-Guided Risk Assessment for Acute Kidney Injury: Time for Clinical Implementation?
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Albert C, Haase M, Albert A, Zapf A, Braun-Dullaeus RC, Haase-Fielitz A
- KMID: 2512729
- Ann Lab Med.
- 2021 Jan;41(1):1-15.
- doi: 10.3343/alm.2021.41.1.1
Acute kidney injury (AKI) is a common and serious complication in hospitalized patients, which continues to pose a clinical challenge for treating physicians. The most recent Kidney Disease Improving Global... -
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- Anticancer effects of D-pinitol in human oral squamous carcinoma cells
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Shin HC, Bang TH, Kang HM, Park BS, Kim IR
- KMID: 2510194
- Int J Oral Biol.
- 2020 Dec;45(4):152-161.
- doi: 10.11620/IJOB.2020.45.4.152
D-pinitol is an analog of 3-methoxy-D-chiro-inositol found in beans and plants. D-pinitol has anti-inflammatory, antidiabetic, and anticancer effects. Additionally, D-pinitol induces apoptosis and inhibits metastasis in breast and prostate cancers.... -
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- Imatinib and GNF-5 Exhibit an Inhibitory Effect on Growth of Hepatocellar Carcinoma Cells by Downregulating S-phase Kinase-associated Protein 2
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Zhang H, Yi J, Yoon D, Ryoo Z, Lee I, Kim M
- KMID: 2510156
- J Cancer Prev.
- 2020 Dec;25(4):252-257.
- doi: 10.15430/JCP.2020.25.4.252
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is one of the leading causes of cancer-related deaths worldwide. Imatinib and GNF-5 are breakpoint cluster region-Abelson murine leukemia... -
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- Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells
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Kim MJ, Kang YJ, Sung B, Jang JY, Ahn YR, Oh HJ, Choi H, Choi I, Im E, Moon HR, Chung HY, Kim ND
- KMID: 2508211
- Biomol Ther.
- 2020 Nov;28(6):561-568.
- doi: 10.4062/biomolther.2020.153
We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin... -
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- Survival Association and Cell Cycle Effects of B7H3 in Neuroblastoma
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Zhang H, Zhang J, Li C, Xu H, Dong R, Chen CC, Hua W
- KMID: 2508600
- J Korean Neurosurg Soc.
- 2020 Nov;63(6):707-716.
- doi: 10.3340/jkns.2019.0255
Objective : The function of B7H3, a member of the B7 family of proteins, in neuroblastoma (NB) remains poorly characterized. Here we examine the expression pattern of B7H3 in clinical... -
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- Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43＋ Cells via Cell-Cycle Regulation
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Zeng J, Zhang H, Liu Y, Sun W, Yi D, Zhu L, Zhang Y, Pan X, Chen Y, Zhou Y, Bian G, Lai M, Zhou Q, Liu J, Chen B, Ma F
- KMID: 2504333
- Int J Stem Cells.
- 2020 Jul;13(2):202-211.
- doi: 10.15283/ijsc20033
Background and Objectives: p21, an important member of the Cip/Kip family, is involved in inhibitory effects of RUNX1b overexpression during the early stage of human hematopoiesis. Methods and Results: We established... -
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- Peanut Sprout Extracts Cultivated with Fermented Sawdust Medium Inhibits Benign Prostatic Hyperplasia In Vitro and In Vivo
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Song JH, Hwang B, Chung HJ, Moon B, Kim JW, Ko K, Kim BW, Kim WR, Kim WJ, Myung SC, Moon SK
- KMID: 2503007
- World J Mens Health.
- 2020 Jul;38(3):385-396.
- doi: 10.5534/wjmh.190173
Purpose: In this study, we tested whether the resveratrol-enriched peanut sprout extracts cultivated with fermented sawdust medium (PSEFS) could suppress benign prostatic hyperplasia (BPH) in vitro and in vivo. Materials and... -
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- The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells
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Chiang CY, Hsu KD, Lin YY, Hsieh CW, Liu JM, Lu TY, Cheng KC
- KMID: 2504109
- Mycobiology.
- 2020 Jun;48(3):219-227.
- doi: 10.1080/12298093.2020.1746064
Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent... -
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- NUP210 and MicroRNA-22 Modulate Fasto Elicit HeLa Cell Cycle Arrest
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Gu Q, Hou W, Liu H, Shi L, Zhu Z, Ye W, Ni X
- KMID: 2500074
- Yonsei Med J.
- 2020 May;61(5):371-381.
- doi: 10.3349/ymj.2020.61.5.371
Purpose: Cervical cancer is one of the most fatal diseases among women in under-developed countries. To improve cervical cancer treatment, discovery of new targets is needed. In this study, we investigated... -
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