- Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients
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Dirican E, Özcan H, Uzunçakmak SK, Takım U
- KMID: 2539661
- Clin Psychopharmacol Neurosci.
- 2023 Feb;21(1):171-178.
- doi: 10.9758/cpn.2023.21.1.171
Objective: Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the... -
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- Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells
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Kang KR, Kim JS, Lim H, Seo JY, Park JH, Chun HS, Yu SK, Kim HJ, Kim CS, Kim DK
- KMID: 2534521
- Korean J Physiol Pharmacol.
- 2022 Nov;26(6):447-456.
- doi: 10.4196/kjpp.2022.26.6.447
The present study was carried out to investigate the effect of Arctigenin on cell growth and the mechanism of cell death elicited by Arctigenin were examined in FaDu human pharyngeal... -
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- Stem cells from human exfoliated deciduous teeth attenuate trigeminal neuralgia in rats by inhibiting endoplasmic reticulum stress
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Yang Z, Wang C, Zhang X, Li J, Zhang Z, Tan Z, Wang J, Zhang J, Bai X
- KMID: 2533978
- Korean J Pain.
- 2022 Oct;35(4):383-390.
- doi: 10.3344/kjp.2022.35.4.383
Background: The treatment of trigeminal neuralgia remains a challenging issue. Stem cells from human exfoliated deciduous teeth (SHED) provide optimized therapy for chronic pain. This study aimed to investigate the mechanisms... -
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- The Growth Inhibitory Effect on B16F10 Melanoma Cells by 4-BPCA, an Amide Derivative of Caffeic Acid
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Park Y, Kang SU, Lee J, Jang BC
- KMID: 2533289
- Keimyung Med J.
- 2022 Jun;41(1):17-23.
- doi: 10.46308/kmj.2022.00066
Caffeic acid (CA) is a phenolic compound found naturally in plants and foods. CA and its natural derivatives are reported to have anti-cancer effects on many cancers, including melanoma. (E)-N-(4-Butylphenyl)-3-(3,4-dihydroxyphenyl)acrylamide... -
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- Impact of imatinib administration on the mouse ovarian follicle count and levels of intra-ovarian proteins related to follicular quality
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Kim SJ, Kim TE, Jee BC
- KMID: 2531710
- Clin Exp Reprod Med.
- 2022 Jun;49(2):93-100.
- doi: 10.5653/cerm.2022.05218
Objective: The impact of imatinib, a tyrosine kinase inhibitor, on ovarian follicles and several proteins related to follicular function and apoptosis was investigated in mice. Methods: Saline, cyclophosphamide (Cp; 50 or... -
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- Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
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Park C, Choi EO, Hwangbo H, Lee H, Jeong JW, Han MH, Moon SK, Yun SJ, Kim WJ, Kim GY, Hwang HJ, Choi YH
- KMID: 2530394
- Nutr Res Pract.
- 2022 Jun;16(3):330-343.
- doi: 10.4162/nrp.2022.16.3.330
BACKGROUND/OBJECTIVES: Zanthoxylum schinifolium is traditionally used as a spice for cooking in East Asian countries. This study was undertaken to evaluate the anti-proliferative potential of ethanol extracts of Z. schinifolium... -
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- Clinicopathologic and protein markers distinguishing the “polymerase epsilon exonuclease” from the “copy number low” subtype of endometrial cancer
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Kim K, Hwangbo S, Kim H, Kim YB, No JH, Suh DHx, Park T
- KMID: 2536985
- J Gynecol Oncol.
- 2022 May;33(3):e27.
- doi: 10.3802/jgo.2022.33.e27
Objective The need to perform genetic sequencing to diagnose the polymerase epsilon exonuclease (POLE) subtype of endometrial cancer (EC) hinders the adoption of molecular classification. We investigated clinicopathologic and protein markers... -
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- N-Acetyl cysteine mitigates histopathological changes and inflammatory genes expressions in the liver of cadmium exposed rats
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Aala J, Harchegani AB, Monsef HA, Mohsenifar Z, Ebrahimi P, Parvizi MR
- KMID: 2525322
- Environ Anal Health Toxicol.
- 2021 Dec;36(4):e2021024.
- doi: 10.5620/eaht.2021024
This study aimed to consider the expression of Nrf2, NLRP3 and caspase 1 genes, as well as oxidative stress, and the protective role of N-acetyl cysteine (NAC) in the liver... -
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- Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferatoractivated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition nuclear factor-kappaB/caspase 3
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Emeka PM, Rasool ST, Morsy MA, Hairul Islam MI, Chohan MS
- KMID: 2516871
- Korean J Physiol Pharmacol.
- 2021 Jul;25(4):321-331.
- doi: 10.4196/kjpp.2021.25.4.321
Vancomycin, an antibiotic used occasionally as a last line of treatment for methicillin-resistant Staphylococcus aureus, is reportedly associated with nephrotoxicity. This study aimed at evaluating the protective effects of lutein... -
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- Cucurbitacin E’s Anti-Cancer Effects on HCT116 Human Colon Cancer Cells by Controlling Expression and Phosphorylation Levels of Caspase-9, eIF-2α, and ATF-4
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Yadav AK, Jang BC
- KMID: 2502841
- Keimyung Med J.
- 2020 Jun;39(1):6-13.
- doi: 10.46308/kmj.2020.00059
Cucurbitacin E is a pivotal member of the cucurbitacin family and has been shown to have anti-cancer effects. However, until now, the anti-cancer effect and mode of action of cucurbitacin... -
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- High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders
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Ayaydın H, Kirmit A, Çelik H, Akaltun , Koyuncu , Ulgar
- KMID: 2502152
- Clin Psychopharmacol Neurosci.
- 2020 May;18(2):270-278.
- doi: 10.9758/cpn.2020.18.2.270
Objective: The purpose of this study was therefore to investigate whether neuronal, axonal, and glial cell markers (Neuron-specific enolase [NSE], tau, serum 100 beta protein [S100B], respectively) and apoptosis markers... -
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- Functional Expression of Choline Transporter-Like Protein 1 in LNCaP Prostate Cancer Cells: A Novel Molecular Target
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Saiki I, Yara M, Yamanaka T, Uchino H, Inazu M
- KMID: 2507834
- Biomol Ther.
- 2020 Mar;28(2):195-201.
- doi: 10.4062/biomolther.2019.097
Prostate cancer is one of the most common cancers in men. Choline PET or PET/CT has been used to visualize prostate cancer, and high levels of choline accumulation have been... -
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- MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
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Liu H, Li S, Jiang W, Li Y
- KMID: 2470910
- Korean Circ J.
- 2020 Mar;50(3):250-263.
- doi: 10.4070/kcj.2019.0107
BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion... -
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- Survival of isolated human preantral follicles after vitrification: Analyses of morphology and Fas ligand and caspase-3 mRNA expression
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Wiweko B, Soebijanto S, Boediono A, Mansyur M, Siregar NC, Suryandari DA, Aulia A, Djuwantono T, Affandi B
- KMID: 2469591
- Clin Exp Reprod Med.
- 2019 Dec;46(4):152-165.
- doi: 10.5653/cerm.2019.00143
OBJECTIVE: This study aimed to examine the effect of vitrification on apoptosis and survival in human preantral follicles after thawing. METHODS: This experimental study was conducted at an acute tertiary care... -
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- Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner
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Gim E, Shim DW, Hwang I, Shin OS, Yu JW
- KMID: 2466610
- Immune Netw.
- 2019 Dec;19(6):e40.
- doi: 10.4110/in.2019.19.e40
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neurological disorders including Guillain-Barré syndrome and microcephaly. The host innate immune responses against ZIKV infection are essential for protection; however,... -
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- Pro-Inflammatory Role of S1P₃ in Macrophages
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Heo JY, Im DS
- KMID: 2455092
- Biomol Ther.
- 2019 Jul;27(4):373-380.
- doi: 10.4062/biomolther.2018.215
Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors S1Pâ‚ and S1Pâ‚‚ on cell motility... -
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- Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells
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Choi EO, Hwang HJ, Choi YH
- KMID: 2447436
- J Cancer Prev.
- 2019 Mar;24(1):11-19.
- doi: 10.15430/JCP.2019.24.1.11
BACKGROUND: The roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used in traditional medicine for treatment of various diseases. In this study, we investigated the effects of ethanol extracts... -
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- Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases
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Yi YS
- KMID: 2429833
- Immune Netw.
- 2018 Dec;18(6):e41.
- doi: 10.4110/in.2018.18.e41
Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomes — multiprotein... -
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- Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets
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Nagashima , Nishiyama , Iwao B, Kawai Y, Ishii C, Yamanaka T, Uchino H, Inazu M
- KMID: 2420391
- Biomol Ther.
- 2018 Jul;26(4):399-408.
- doi: 10.4062/biomolther.2017.113
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the... -
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- Effect of caspases and RANKL induced by heavy force in orthodontic root resorption
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Minato Y, Yamaguchi , Shimizu M, Kikuta J, Hikida T, Hikida M, Suemitsu M, Kuyama K, Kasai K
- KMID: 2417967
- Korean J Orthod.
- 2018 Jul;48(4):253-261.
- doi: 10.4041/kjod.2018.48.4.253
OBJECTIVE: Orthodontic root resorption (ORR) due to orthodontic tooth movement is a difficult treatment-related adverse event. Caspases are important effector molecules for apoptosis. At present, little is known about the... -
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