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Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys

Awazu M

Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)...
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Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse

Kwak DH, Kim JS, Chang KT, Choo YK

Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways...
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Ghrelin Inhibits Oligodendrocyte Cell Death by Attenuating Microglial Activation

Lee JY, Yune TY

BACKGROUND: Recently, we reported the antiapoptotic effect of ghrelin in spinal cord injury-induced apoptotic cell death of oligodendrocytes. However, how ghrelin inhibits oligodendrocytes apoptosis, is still unknown. Therefore, in the...
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Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity

Xia A, Xue Z, Wang W, Zhang T, Wei T, Sha X, Ding Y, Zhou W

To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley...
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The Effect of Ginkgo Biloba on the Survival of Spiral Ganglion Neurons in Rats

Lee IW, Park HM, Chon KM, Park SH, Shin SK, Goh EK

BACKGROUND AND OBJECTIVES: Ginkgo biloba extract (GBE) enhances cell survival in various organs. GBE protects nerve cells in the central nervous system and is clinically applied in Parkinson's and Alzheimer's...
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Chlorpromazine activates p21(Waf1/Cip1) gene transcription via early growth response-1 (Egr-1) in C6 glioma cells

Shin SY, Kim CG, Kim SH, Kim YS, Lim Y, Lee YH

2-Chloro-10-[3(-dimethylamino)propyl]phenothiazinemonohydrochloride (chlorpromazine) is a phenothiazine derivative used clinically to control psychotic disorders. It also exhibits an anticancer activity. Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase...
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Celecoxib Attenuates Kainic Acid-induced Neuronal Cell Death Through Suppression of Microglial c-Jun N-terminal Kinase Phosphorylation

Byun JS, Cho SY, Kim SI, Kwon YS, Jeon SH, Kim MJ, Lee HJ, Kim SS, Chun W

In the present study, neuroprotective property of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and its underlying mechanism were examined in the animal model of kainic acid (KA)-induced excitotoxicity. KA, administered...
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Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death

Seok JH, Park KA, Byun HS, Won M, Shin S, Choi BL, Lee H, Kim YR, Hong JH, Park J, Hur GM

Activation of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is an important cellular response that modulates the outcome of the cells which are exposed to...
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PDTC Inhibits TNF-alpha-Induced Apoptosis in MC3T3E1 Cells

Chae HJ, Bae J, Chae SW

  • KMID: 2285287
  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):199-206.
Osteoblasts are affected by TNF-alpha overproduction by immune cells during inflammation. It has been suggested that functional NF-kappaB sites are involved in TNF-alpha-induced bone resorption. Thus, we explored the effect...
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