- Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
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Awazu M
- KMID: 2377561
- Child Kidney Dis.
- 2017 Apr;21(1):1-7.
- doi: 10.3339/jkspn.2017.21.1.1
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)... -
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- Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse
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Kwak DH, Kim JS, Chang KT, Choo YK
- KMID: 2413126
- J Vet Sci.
- 2016 Sep;17(3):279-287.
- doi: 10.4142/jvs.2016.17.3.279
Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways... -
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- Ghrelin Inhibits Oligodendrocyte Cell Death by Attenuating Microglial Activation
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Lee JY, Yune TY
- KMID: 2169475
- Endocrinol Metab.
- 2014 Sep;29(3):371-378.
- doi: 10.3803/EnM.2014.29.3.371
BACKGROUND: Recently, we reported the antiapoptotic effect of ghrelin in spinal cord injury-induced apoptotic cell death of oligodendrocytes. However, how ghrelin inhibits oligodendrocytes apoptosis, is still unknown. Therefore, in the... -
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- Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity
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Xia A, Xue Z, Wang W, Zhang T, Wei T, Sha X, Ding Y, Zhou W
- KMID: 2285493
- Korean J Physiol Pharmacol.
- 2014 Feb;18(1):67-72.
- doi: 10.4196/kjpp.2014.18.1.67
To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley... -
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- The Effect of Ginkgo Biloba on the Survival of Spiral Ganglion Neurons in Rats
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Lee IW, Park HM, Chon KM, Park SH, Shin SK, Goh EK
- KMID: 2074180
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2011 Aug;54(8):526-531.
- doi: 10.3342/kjorl-hns.2011.54.8.526
BACKGROUND AND OBJECTIVES: Ginkgo biloba extract (GBE) enhances cell survival in various organs. GBE protects nerve cells in the central nervous system and is clinically applied in Parkinson's and Alzheimer's... -
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- Chlorpromazine activates p21(Waf1/Cip1) gene transcription via early growth response-1 (Egr-1) in C6 glioma cells
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Shin SY, Kim CG, Kim SH, Kim YS, Lim Y, Lee YH
- KMID: 946639
- Exp Mol Med.
- 2010 May;42(5):395-405.
- doi: 10.3858/emm.2010.42.5.041
2-Chloro-10-[3(-dimethylamino)propyl]phenothiazinemonohydrochloride (chlorpromazine) is a phenothiazine derivative used clinically to control psychotic disorders. It also exhibits an anticancer activity. Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase... -
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- Celecoxib Attenuates Kainic Acid-induced Neuronal Cell Death Through Suppression of Microglial c-Jun N-terminal Kinase Phosphorylation
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Byun JS, Cho SY, Kim SI, Kwon YS, Jeon SH, Kim MJ, Lee HJ, Kim SS, Chun W
- KMID: 2165291
- Exp Neurobiol.
- 2009 Jun;18(1):13-18.
- doi: 10.5607/en.2009.18.1.13
In the present study, neuroprotective property of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and its underlying mechanism were examined in the animal model of kainic acid (KA)-induced excitotoxicity. KA, administered... -
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- Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death
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Seok JH, Park KA, Byun HS, Won M, Shin S, Choi BL, Lee H, Kim YR, Hong JH, Park J, Hur GM
- KMID: 1838357
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):185-191.
- doi: 10.4196/kjpp.2008.12.4.185
Activation of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is an important cellular response that modulates the outcome of the cells which are exposed to... -
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- PDTC Inhibits TNF-alpha-Induced Apoptosis in MC3T3E1 Cells
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Chae HJ, Bae J, Chae SW
- KMID: 2285287
- Korean J Physiol Pharmacol.
- 2003 Aug;7(4):199-206.
Osteoblasts are affected by TNF-alpha overproduction by immune cells during inflammation. It has been suggested that functional NF-kappaB sites are involved in TNF-alpha-induced bone resorption. Thus, we explored the effect... -
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