- Pitavastatin Induces Apoptosis of Cutaneous Squamous Cell Carcinoma Cells through Geranylgeranyl PyrophosphateDependent c-Jun N-Terminal Kinase Activation
-
Kim KI, Kim SM, Lee YY, Lee Y, Kim CD, Yoon TJ
- KMID: 2541114
- Ann Dermatol.
- 2023 Apr;35(2):116-123.
- doi: 10.5021/ad.22.139
Background: Pitavastatin is a cholesterol-lowering drug and is widely used clinically. In addition to this effect, pitavastatin has shown the potential to induce apoptosis in cutaneous squamous cell carcinoma (SCC)... -
- CITED
-
- Close
- SHARE
-
- Close
- Endoplasmic Reticulum Stress-Mediated p62 Downregulation Inhibits Apoptosis via c-Jun Upregulation
-
Yu W, Wang B, Zhou L, Xu G
- KMID: 2513487
- Biomol Ther.
- 2021 Mar;29(2):195-204.
- doi: 10.4062/biomolther.2020.089
Cereblon (CRBN), a substrate receptor of cullin 4-RING E3 ligase (CRL4) regulates the ubiquitination and degradation of c-Jun, mediating the lipopolysaccharide-induced cellular response. However, the upstream signaling pathway that regulates... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-inflammatory Effect of Glucagon Like Peptide-1 Receptor Agonist, Exendin-4, through Modulation of IB1/JIP1 Expression and JNK Signaling in Stroke
-
Kim S, Jeong J, Jung HS, Kim B, Kim YE, Lim DS, Kim SD, Song YS
- KMID: 2389009
- Exp Neurobiol.
- 2017 Aug;26(4):227-239.
- doi: 10.5607/en.2017.26.4.227
Glucagon like peptide-1 (GLP-1) stimulates glucose-dependent insulin secretion. Dipeptidyl peptidase-4 (DPP-4) inhibitors, which block inactivation of GLP-1, are currently in clinical use for type 2 diabetes mellitus. Recently, GLP-1 has... -
- CITED
-
- Close
- SHARE
-
- Close
- Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
-
Awazu M
- KMID: 2377561
- Child Kidney Dis.
- 2017 Apr;21(1):1-7.
- doi: 10.3339/jkspn.2017.21.1.1
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)... -
- CITED
-
- Close
- SHARE
-
- Close
- Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse
-
Kwak DH, Kim JS, Chang KT, Choo YK
- KMID: 2413126
- J Vet Sci.
- 2016 Sep;17(3):279-287.
- doi: 10.4142/jvs.2016.17.3.279
Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways... -
- CITED
-
- Close
- SHARE
-
- Close
- Ghrelin Inhibits Oligodendrocyte Cell Death by Attenuating Microglial Activation
-
Lee JY, Yune TY
- KMID: 2169475
- Endocrinol Metab.
- 2014 Sep;29(3):371-378.
- doi: 10.3803/EnM.2014.29.3.371
BACKGROUND: Recently, we reported the antiapoptotic effect of ghrelin in spinal cord injury-induced apoptotic cell death of oligodendrocytes. However, how ghrelin inhibits oligodendrocytes apoptosis, is still unknown. Therefore, in the... -
- CITED
-
- Close
- SHARE
-
- Close
- Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity
-
Lee HJ, Shin YK, Park HT
- KMID: 2165513
- Exp Neurobiol.
- 2014 Jun;23(2):130-137.
- doi: 10.5607/en.2014.23.2.130
Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal development to allow saltatory conduction of nerve impulses. Well-organized structures of myelin sheathes are maintained throughout life unless nerves... -
- CITED
-
- Close
- SHARE
-
- Close
- N-(p-Coumaryol)-Tryptamine Suppresses the Activation of JNK/c-Jun Signaling Pathway in LPS-Challenged RAW264.7 Cells
-
Vo VA, Lee JW, Park JH, Kwon JH, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2170637
- Biomol Ther.
- 2014 May;22(3):200-206.
N-(p-Coumaryol) tryptamine (CT), a phenolic amide, has been reported to exhibit anti-oxidant and anti-inflammatory activities. However, the underlying mechanism by which CT exerts its pharmacological properties has not been clearly... -
- CITED
-
- Close
- SHARE
-
- Close
- The Expression of c-Jun and JunB in Various Skin Tumors
-
Ko BJ, Cho MK, Park YL, Lee JS, Lee JH, Whang KU
- KMID: 1802074
- Korean J Dermatol.
- 2014 Apr;52(4):230-236.
BACKGROUND: c-Jun along with JunB, JunD, and the Fos group proteins comprise the core members of the activator protein 1 (AP1) family of transcription factors. Recently, many studies have demonstrated... -
- CITED
-
- Close
- SHARE
-
- Close
- Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity
-
Xia A, Xue Z, Wang W, Zhang T, Wei T, Sha X, Ding Y, Zhou W
- KMID: 2285493
- Korean J Physiol Pharmacol.
- 2014 Feb;18(1):67-72.
- doi: 10.4196/kjpp.2014.18.1.67
To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley... -
- CITED
-
- Close
- SHARE
-
- Close
- Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration
-
Kwon HJ, Hong SK, Yoon WK, Nam KH, Choi IP, Kim DY, Kim HC, Won YS
- KMID: 1705555
- J Vet Sci.
- 2013 Sep;14(3):257-262.
- doi: 10.4142/jvs.2013.14.3.257
Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1... -
- CITED
-
- Close
- SHARE
-
- Close
- Co-localization of activating transcription factor 3 and phosphorylated c-Jun in axotomized facial motoneurons
-
Park BG, Lee JS, Lee JY, Song DY, Jeong SW, Cho BP
- KMID: 1447435
- Anat Cell Biol.
- 2011 Sep;44(3):226-237.
- doi: 10.5115/acb.2011.44.3.226
Activating transcription factor 3 (ATF3) and c-Jun play key roles in either cell death or cell survival, depending on the cellular background. To evaluate the functional significance of ATF3/c-Jun in... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effect of Ginkgo Biloba on the Survival of Spiral Ganglion Neurons in Rats
-
Lee IW, Park HM, Chon KM, Park SH, Shin SK, Goh EK
- KMID: 2074180
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2011 Aug;54(8):526-531.
- doi: 10.3342/kjorl-hns.2011.54.8.526
BACKGROUND AND OBJECTIVES: Ginkgo biloba extract (GBE) enhances cell survival in various organs. GBE protects nerve cells in the central nervous system and is clinically applied in Parkinson's and Alzheimer's... -
- CITED
-
- Close
- SHARE
-
- Close
- Chlorpromazine activates p21(Waf1/Cip1) gene transcription via early growth response-1 (Egr-1) in C6 glioma cells
-
Shin SY, Kim CG, Kim SH, Kim YS, Lim Y, Lee YH
- KMID: 946639
- Exp Mol Med.
- 2010 May;42(5):395-405.
- doi: 10.3858/emm.2010.42.5.041
2-Chloro-10-[3(-dimethylamino)propyl]phenothiazinemonohydrochloride (chlorpromazine) is a phenothiazine derivative used clinically to control psychotic disorders. It also exhibits an anticancer activity. Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase... -
- CITED
-
- Close
- SHARE
-
- Close
- Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy
-
Yoon SJ, Yoon YW, Lee BK, Kwon HM, Hwang KC, Kim M, Chang W, Hong BK, Lee YH, Park SJ, Min PK, Rim SJ
- KMID: 1122281
- Exp Mol Med.
- 2009 Nov;41(11):802-811.
- doi: 10.3858/emm.2009.41.11.086
Advanced glycation endproducts (AGEs)-induced vascular smooth muscle cell (VSMCs) proliferation and formation of reactive oxygen species (ROS) are emerging as one of the important mechanisms of diabetic vasculopathy but little... -
- CITED
-
- Close
- SHARE
-
- Close
- Celecoxib Attenuates Kainic Acid-induced Neuronal Cell Death Through Suppression of Microglial c-Jun N-terminal Kinase Phosphorylation
-
Byun JS, Cho SY, Kim SI, Kwon YS, Jeon SH, Kim MJ, Lee HJ, Kim SS, Chun W
- KMID: 2165291
- Exp Neurobiol.
- 2009 Jun;18(1):13-18.
- doi: 10.5607/en.2009.18.1.13
In the present study, neuroprotective property of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and its underlying mechanism were examined in the animal model of kainic acid (KA)-induced excitotoxicity. KA, administered... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential Expression of Activating Transcription Factor-2 and c-Jun in the Immature and Adult Rat Hippocampus Following Lithium-Pilocarpine Induced Status Epilepticus
-
Han SR, Shin C, Park S, Rhyu S, Park J, Kim YI
- KMID: 2396060
- Yonsei Med J.
- 2009 Apr;50(2):200-205.
PURPOSE: Lithium-pilocarpine induced status epilepticus (LPSE) causes selective and age-dependent neuronal death, although the mechanism of maturation-related injury has not yet been clarified. The activating transcription factor-2 (ATF-2) protein is... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparison of the Expression Profile of JunB, c-Jun, and S100A8 (Calgranulin A) in Psoriasis Vulgaris and Guttate Psoriasis
-
Park CC, Kim KJ, Woo SY, Chun JH, Lee KH
- KMID: 2172062
- Ann Dermatol.
- 2009 Feb;21(1):35-38.
- doi: 10.5021/ad.2009.21.1.35
BACKGROUND: Psoriasis is a chronic, inflammatory, immune- mediated skin disease. Recently, several psoriasis-linked genetic loci have been reported; PSORS4 contains S100A8 (calgranulin A), and PSOR6 (19p13) locus harbors JunB (19p13.2).... -
- CITED
-
- Close
- SHARE
-
- Close
- Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin
-
Min BW, Kim CG, Ko J, Lim Y, Lee YH, Shin SY
- KMID: 1072950
- Exp Mol Med.
- 2008 Dec;40(6):699-708.
- doi: 10.3858/emm.2008.40.6.699
Expression of protein kinase C-delta (PKC delta) is up-regulated by apoptosis-inducing stimuli. However, very little is known about the signaling pathways that control PKC delta gene transcription. In the present... -
- CITED
-
- Close
- SHARE
-
- Close
- Activation of Transcription Factor NF-kappaB and c-Jun/AP-1 by Various Compositions of Particles in Osteoclast Precursor Cells
-
Kim YS, Kwon SY, Han SK, Kwon JY, Choi NY
- KMID: 2162629
- J Korean Hip Soc.
- 2008 Sep;20(3):209-214.
- doi: 10.5371/jkhs.2008.20.3.209
PURPOSE: This study was performed in order to investigate the effects of various particle preparations on NF-kappaB and c-Jun/AP-1 activity in osteoclast precursor cells. MATERIALS AND METHODS: Osteoclast precursor cells isolated... -
- CITED
-
- Close
- SHARE
-
- Close
