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Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection

Lim JH, Chung BH, Lee SH, Jung HY, Choi JY, Cho JH, Park SH, Kim YL, Kim CD

Kidney transplantation is the preferred treatment for patients with end-stage kidney disease, because it prolongs survival and improves quality of life. Allograft biopsy is the gold standard for diagnosing allograft...
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Time-integrated Cumulative Parameters Predictive of Radiographic Progression of Rheumatoid Arthritis: Real-world Data From a Prospective Single-center Cohort

Park Y, Li ML, Kim JW, Koh JH, Park YJ, Kim WU

Objective: With many chronic inflammatory diseases, outcomes are determined by assessing both disease activity at presentation and cumulative activity over time. Here, we investigated whether cumulative activity better reflects the...
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Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer

An S, Shim H, Kim K, Kim B, Bang HJ, Do H, Lee HR, Kim Y

We aimed to review whether pretreatment inflammatory markers reflect the short- and long-term outcomes of patients with colon cancer, rectal cancer, colon and rectal cancers, and metastatic colorectal cancer (CRC)....
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Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study

Shim Y

Background and Purpose: Neurofilament light chain (NfL) has been considered as a biomarker for neurodegenerative diseases including Alzheimer’s disease (AD). We measured plasma NfL levels in older adults with cognitive...
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A development study of drain fluid gastrografin as a biomarker of anastomotic leak

Clark DA, Yeoh E, Edmundson A, Harris C, Stevenson A, Steffens D, Solomon M

Purpose: Anastomotic leakage (AL) is the anathema of colorectal surgery. Its occurrence leads to increased morbidity and mortality and a prolonged hospital stay. Much work has gone into studying various...
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Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease

Jung CY, Yoo TH

Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD has failed to decline over the past...
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Diagnostic performance of serum exosomal miRNA-720 in hepatocellular carcinoma

Jang JW, Kim JM, Kim HS, Kim JS, Han JW, Lee SK, Nam H, Sung PS, Bae SH, Choi JY, Yoon SK

Background/Aim: Hepatocellular carcinoma (HCC) is associated with poor prognosis, largely due to late detection. Highly accurate biomarkers are urgently needed to detect early-stage HCC. Our study aims to explore the...
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Disease predictability review using common biomarkers appearing in diabetic nephropathy and neurodegeneration of experimental animals

Yi SS

It is recently known that the kidney and brain have a very rich distribution of blood vessels, and the histological structures of micro-vessels are very similar. Therefore, a number of...
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Multidimensional Biomarker Analysis Including Mitochondrial Stress Indicators for Nonalcoholic Fatty Liver Disease

Chang E, Chang JS, Kong ID, Baik SK, Kim MY, Park KS

Nonalcoholic fatty liver disease (NAFLD) is accompanied by a complex and multifactorial pathogenesis with sequential progressions from inflammation to fibrosis and then to cancer. This heterogeneity interferes with the development...
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Human Leukocyte Antigens and Biomarkers in Type 1 Diabetes Mellitus Induced by Immune-Checkpoint Inhibitors

Inaba H, Kaido Y, Ito S, Hirobata T, Inoue G, Sugita T, Yamamoto Y, Jinnin M, Kimura H, Kobayashi T, Iwama S, Arima H, Matsuoka T

Background: Type 1 diabetes mellitus induced by immune-checkpoint inhibitors (ICI-T1DM) is a rare critical entity. However, the etiology of ICI-T1DM remains unclear. Methods: In order to elucidate risk factors for ICI-T1DM,...
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Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma

Sodnom-Ish B, Eo MY, Myoung H, Lee JH, Kim SM

Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC)...
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ADRB3, ROCK2, and GEF Levels in Overactive Bladder Patients

Fırat E, Aybek Z, Aybek H

Purpose: The aim of this study was to evaluate changes in levels of adrenergic receptor β3 (ADRB3), Rho-related kinase 2 (ROCK2), and guanine nucleotide exchange factor (GEF), which play key...
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Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review

Park Y, Go TH, Hong SH, Kim SH, Han JH, Kang Y, Kang DR

Purpose: The study aimed to identify which digital biomarkers are collected and which specific devices are used according to vulnerable and susceptible individual characteristics in a living-lab setting. Materials and Methods:...
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Beyond Prostate Specific Antigen: New Prostate Cancer Screening Options

Narain TA, Sooriakumaran P

Prostate specific antigen (PSA) is one of the best-known biomarkers for screening, diagnosis and follow-up of patients for prostate cancer. Owing to several inherent limitations with PSA, various newer blood...
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Plasma Neutrophil Gelatinase-associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infection

Son MH, Yim HE, Yoo KH

Purpose: We aimed to study the association of plasma neutrophil gelatinase-associated lipocalin (pNGAL) and leukocyte differential count in children with febrile urinary tract infection (UTI). Methods: Medical records of 154 children...
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Potential biomarkers and signaling pathways associated with the pathogenesis of primary salivary gland carcinoma: a bioinformatics study

Bayat Z, Ahmadi-Motamayel F, Parsa MS, Taherkhani A

Salivary gland carcinoma (SGC) is rare cancer, constituting 6% of neoplasms in the head and neck area. The most responsible genes and pathways involved in the pathology of this disorder...
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A validated simple LC-MS/MS method for quantifying trimethylamine N-oxide (TMAO) using a surrogate matrix and its clinical application

Li Y, Kang J, Lee Y, Chung JY, Cho JY

Trimethylamine N-oxide (TMAO) is a small molecular amine oxide generated from dietary choline and carnitine through intestinal microbial metabolism. Recently, TMAO has attracted much public attention as its role...
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Point-of-care lactate: a predictor of emergency medicine resource use and outcomes in infants with diarrhea

Lee J, Moon HJ, Kim DE, Jeoung D, Kim HJ, Lee HJ, Lee D

Purpose: Fluid therapy for diarrhea-induced dehydration inadvertently increases emergency department length of stay (EDLOS). To prevent this delay, we investigated the usefulness of triage using point-of-care (POC) lactate in infants...
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Hepatocyte growth factor and soluble cMet levels in plasma are prognostic biomarkers of mortality in patients with severe acute kidney injury

Li L, An JN, Lee J, Shin DJ, Zhu SM, Kim JH, Kim DK, Ryu DR, Kim S, Lee JP

Background: Hepatocyte growth factor (HGF)/cMet pathway is necessary for repair and regeneration following acute kidney injury (AKI). We evaluated the clinical potential of plasma HGF and soluble cMet as prognostic...
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Paradigm shift for defining the resectability of pancreatic cancer

Kang MJ, Kim SW

Supported by the expanding indications for neoadjuvant therapy (NAT) for advanced pancreatic cancer (PC), the concept of resectability has evolved from being mostly based on the anatomical tumor extent to...
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