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Hyperoxygenation Treatment Reduces Beta-amyloid Deposition via MeCP2-dependent Upregulation of MMP-2 and MMP-9 in the Hippocampus of Tg-APP/PS1 Mice

Choi J, Kwon H, Han PL

  • KMID: 2519891
  • Exp Neurobiol.
  • 2021 Aug;30(4):294-307.
  • doi: 10.5607/en21014
Recently we reported that hyperoxygenation treatment reduces amyloid-beta accumulation and rescues cognitive impairment in the Tg-APP/PS1 mouse model of Alzheimer’s disease. In the present study, we continue to investigate the...
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The Clinical Usefulness of Beta-Amyloid Positron Emission Tomography Imaging in the Elderly Patients: Case Series & Brief Review

Oh JH, Na SJ, Lee SY, Lee HK, Lee KU, Kweon YS, Ahn RY, Lee SY, Lee CT

The aim was to evaluate the diagnostic utility of beta-amyloid positron emission tomography (PET) in elderly patients with cognitive impairment in the clinical setting. Five subjects underwent beta-amyloid PET imaging...
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Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment

Seo EH, Kim SH, Park SH, Kang SH, Choo IH, Alzheimer's Disease Neuroimaging Initiative

This study aimed to investigate the independent and interactive influences of apolipoprotein E (APOE) epsilon4 and beta-amyloid (Abeta) on multiple cognitive domains in a large group of cognitively normal (CN)...
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PET Radioligands for Imaging of Tau Pathology: Current Status

Choe YS, Lee KH

The incidence of Alzheimer's disease (AD), a progressive neurodegenerative disorder, continues to soar with the rapid growth of the elderly population, thus creating an enormous social and economic burden. Although...
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Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer's disease

Yan JJ, Ahn WG, Jung JS, Kim HS, Hasan MA, Song DK

  • KMID: 2313754
  • Nutr Res Pract.
  • 2014 Aug;8(4):386-390.
BACKGROUND: Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS: We investigated the effects of ADA extract on two mouse models of Alzheimer's...
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Effects of Flavonoid Compounds on beta-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons

Choi SM, Kim BC, Cho YH, Choi KH, Chang J, Park MS, Kim MK, Cho KH, Kim JK

Excessive accumulation of beta-amyloid peptide (Abeta) is one of the major mechanisms responsible for neuronal death in Alzheimer's disease. Flavonoids, primarily antioxidants, are a group of polyphenolic compounds synthesized in...
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Biochemical Biomarkers for Alzheimer's Disease in Cerebrospinal Fluid and Peripheral Blood

Lee YM, Choi WJ, Park M, Kim E

  • KMID: 2334169
  • J Korean Geriatr Psychiatry.
  • 2012 Jun;16(1):17-23.
The diagnosis of Alzheimer's disease (AD) is still obscure even to specialists. To improve the diagnostic accuracy, to find at-risk people as early as possible, to predict the efficacy or...
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Inhibition of beta-amyloid(1-40) Peptide Aggregation and Neurotoxicity by Citrate

Park YH, Kim YJ, Son IH, Yang HD

The accumulation of beta-amyloid (A beta) aggregates is a characteristic of Alzheimer's disease (AD). Furthermore, these aggregates have neurotoxic effects on cells, and thus, molecules that inhibit A beta aggregate...
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Expression Change of Complement Regulator Genes of the Human Astrocytoma Cell Line after A beta1-42 and Interferon Gamma Administration

Choi YS, Kim SH

  • KMID: 2338935
  • J Korean Geriatr Soc.
  • 2008 Dec;12(4):235-245.
BACKGROUND: We determined the changes of complement regulator gene expression in the amyloid-beta1-42(A beta1-42) and interferon-gamma(IFN-gamma)-stimulated human astrocytoma cell line. METHODS: The human astrocytoma cell line, U373MG, was stimulated with IFN-gamma(62.5-1,000U/ml)...
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The Effect of Acetylcholine Esterase Inhibitor on Cerebrospinal Fluid beta-Amyloid 1-42 and Phosphorylated Tau Protein in Korean Alzheimer's Disease Patients: Preliminary Study

Lee EH, Youn YC, Park KY, Min JH, Kwon OS, Lee HO, Hong HJ

  • KMID: 2185066
  • J Korean Neurol Assoc.
  • 2008 Aug;26(3):224-230.
BACKGROUND: Alzheimer's disease (AD) is characterized by the pathology of amyloid plaques and tau-associated neurofibrillary tangles. Acetylcholine esterase (AChE) transforms the beta-amyloid monomer into an oligomer, and increases beta-amyloid aggregation...
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Radiosynthesis of [11C]6-OH-BTA-1 in Different Media and Confirmation of Reaction By-products

Lee HJ, Jeong JM, Lee YS, Kim HW, Lee EK, Lee DS, Chung JK, Lee MC

  • KMID: 1518947
  • Nucl Med Mol Imaging.
  • 2007 Jun;41(3):241-246.
PURPOSE: [11C]6-OH-BTA-1 ([N-methyl-11C]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole, 1), a -amyloid imaging agent for the diagnosis of Alzheimer's disease in PET, can be labeled with higher yield by a simple loop method. During the synthesis...
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beta-Amyloid Imaging Probes

Jeong JM

  • KMID: 2313031
  • Nucl Med Mol Imaging.
  • 2007 Apr;41(2):112-117.
Imaging distribution of beta-amyloid plaques in Alzheimer's disease is very important for early and accurate diagnosis. Early trial of the beta-amyloid plaques includes using radiolabeled peptides which can be only...
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Protective Effect of Green Tea Extract on Neuronal Cell Death in Alzheimer Model using beta-amyloid Peptide

Lee HJ, Lee DY, Noh YH, Yun JY, Chung YH, Kim KY, Kim SS, Lee WB

  • KMID: 2224490
  • Korean J Anat.
  • 2005 Dec;38(6):543-552.
In the present study, we determined whether green tea extract, EGCG protected against beta-amyloid induced neurotoxicity and learning impairment in vitro and in vivo models. Incubation of SK-N-SH cells with...
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Immunohistochemical Study on GTP-binding Rab6 Expression in the Hippocampal Cortices of the Alzheimer Brain

Cheon YH, Kang YJ, Lee JH, Pyo JS, Baik TK

  • KMID: 2092863
  • Korean J Anat.
  • 2005 Oct;38(5):451-459.
The ras-related GTP binding protein, rab6, is located in late Golgi compartment. Modulation of beta-and gamma-secretase activity may lead to production of beta-amyloid fragments that are ultimately deposited in senile...
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Effect of Ischemic Neuronal Insults on Amyloid Precursor Protein Processing

Lee PH, Hwang EM, Mook-Jung , Huh K, Choi IS

  • KMID: 2343147
  • J Korean Neurol Assoc.
  • 2005 Apr;23(2):241-248.
BACKGROUND: In spite of the different pathogenesis and exclusive respect in the diagnosis of Alzheimer's disease (AD) and vascular dementia (VaD), recent epidemiological and pathological studies indicates that ischemic stroke...
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Neurotoxic Effect of beta-Amyloid Peptide in Hippocampal Slice Culture

Park JS, Jo MS, Jung YJ, Lee KE

Alzheimer's disease(AD) is primarily characterized by neurofibrillary tangles, senile plaques, and neurodegeneration. The major component of senile plaques is the beta-amyloid peptide(A beta), Which is considered to have a causal...
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Detection of Inhibitors of beta-Amyloid Peptide Aggregation in Plant Extracts

Chung MA, Chay KO, Ahn BW

  • KMID: 2172400
  • Chonnam Med J.
  • 2001 Dec;37(4):367-376.
The aggregated beta-amyloid peptides (betaAPs) are suggested to be important in the pathogenesis of Alzheimer's disease. In this study, inhibitory effects of plant extracts on beta-AP aggregation were examined using...
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Neurobiology of Alzheimer's Disease

Chung YC, Seo SW, Lee SH

  • KMID: 2142160
  • J Korean Soc Biol Psychiatry.
  • 2001 Jun;8(1):62-70.
Alzheimer's disease(AD) is associated with a characteristic neuropathology. The major hallmarks of AD are senile plaques(SPs) and neurofibrillary tangles(NFTs). beta-amyloid protein(Abeta) is derived from the proteolysis of amyloid precursor protein(APP)...
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The Effects of Psychotropic Drugs on the beta-Amyloid-Induced Cytotoxicity in PC12 Cells

Kim TS, Lee C, Lee SJ, Toh KY, Kim JJ, Paik IH

  • KMID: 2340493
  • J Korean Neuropsychiatr Assoc.
  • 2000 Sep;39(5):936-943.
OBJECTIVE: Amyloid beta protein(Abeta) has been regarded to be toxic to neurons in vitro. However, the mechanism of action leading to neuronal death remains unknown. In this study, we report...
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Effect of beta-amyloid Peptide on Fine Structure of Cardiac Myocytes in Culture

Sung EK, Lee YS, Sung HK, Park JH, Kim JY, Song IH, Lee YC

  • KMID: 2224560
  • Korean J Anat.
  • 2000 Aug;33(4):497-510.
Several predetermined concentrations of beta-amyloid peptide, (betaA) were administered to the rat cardiac myocyte cultures for three days to determine the effects of betaA. Stainings with congo red and crystal...
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