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Upward trend in follicular lymphoma among the Korean population: 10-year experience at a large tertiary institution

Kim M, Hwang HS, Cho H, Yoon DH, Suh C, Park CS, Go H, Huh J

Background: Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma (NHL) in Western countries. However, it is relatively rare in Asia. This study examined epidemiologic characteristics of FL in...
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Diagnostic Approach for Double-Hit and Triple-Hit Lymphoma Based on Immunophenotypic and Cytogenetic Characteristics of Bone Marrow Specimens

Kim H, Kim HJ, Kim SH

Background: High-grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6 (BCL2/BCL6), also known as double-hit lymphoma (DHL) and/or triple-hit lymphoma (THL), is a new entity of B-cell lymphoma...
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BCL2 Regulation according to Molecular Subtype of Breast Cancer by Analysis of The Cancer Genome Atlas Database

Hwang KT, Kim K, Chang JH, Oh S, Kim YA, Lee JY, Jung SH, Choi IS

PURPOSE: We investigated B-cell lymphoma 2 (BCL2) regulation across DNA, RNA, protein, and methylation status according to molecular subtype of breast cancer using The Cancer Genome Atlas (TCGA) database. MATERIALS AND...
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Investigation of BAX and BCL2 expression and apoptosis in a resveratrol- and prednisolone-treated human T-ALL cell line, CCRF-CEM

Khanzadeh , Hagh MF, Talebi M, Yousefi B, Azimi A, Hossein pour feizi AA, Baradaran

BACKGROUND: The numerous side effects and chemo-resistance of conventional chemical drugs in the treatment of malignancies have led to consideration of the anti-cancer properties of natural products. In the present...
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A Case of Pediatric Precursor B-cell Acute Lymphoblastic Leukemia Associated with Translocations (14;18)(q32;q21) and (8;9)(q24;p13)

Kim HJ, Kim H, Koh KN, Im HJ, Seo JJ, Seo EJ, Park CJ

Precursor B-cell acute lymphoblastic leukemia (ALL), which is the most common subtype of pediatric acute leukemia, generally has a good prognosis. However, the prognosis also depends on the genetic abnormalities...
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Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue

Lee YJ, Kwon SB, Kim CH, Cho HD, Nam HS, Lee SH, Lee MW, Nam DH, Choi CY, Cho MK

BACKGROUND: Reactive oxygen species (ROS) play an important role in the induction of apoptosis under pathological conditions. Recently, a significant increase in ROS production and disrupted apoptosis mechanisms in keloids...
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A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population

Eun YG, Hong IK, Kim SK, Park HK, Kwon S, Chung DH, Kwon KH

  • KMID: 2221873
  • Clin Exp Otorhinolaryngol.
  • 2011 Sep;4(3):149-154.
OBJECTIVES: Among the apoptosis signals, B-cell CLL/lymphoma 2 (BCL2) is a well-known regulator of apoptosis with anti-apoptotic properties. We investigated here whether single nucleotide polymorphisms (SNPs) of the BCL2 were...
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The Combined Effects of Ginkgo Biloba Extracts and Aspirin on Viability of SK-N-MC, Neuroblastoma Cell Line in Hypoxia and Reperfusion Condition

Moon SH, Lee YJ, Park SY, Song KY, Kong MH, Kim JH

OBJECTIVE: The purpose of this study is to investigate the combined effects of ginkgo biloba extract, ginkgolide A and B and aspirin on SK-N-MC, human neuroblastoma cell viability and mRNA...
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The Effect of Glucose Fluctuation on Apoptosis and Function of INS-1 Pancreatic Beta Cells

Kim MK, Jung HS, Yoon CS, Ko JH, Jun HJ, Kim TK, Kwon MJ, Lee SH, Ko KS, Rhee BD, Park JH

BACKGROUND: Blood glucose level continuously fluctuates within a certain range in the human body. In diabetes patients, the extent of such fluctuation is large, despite the strict control of blood...
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The Effects of Mistletoe Extract and Anti-cancer Drugs on the Apoptosis of Gastric Cancer Cells

Lee YJ, Heo SH, Shin DG, Kang SK, Kim IM, Kim TH

  • KMID: 2372877
  • J Korean Gastric Cancer Assoc.
  • 2008 Sep;8(3):120-128.
PURPOSE: Mistletoe extract was widely used for cancer treatment as complementary or alternative therapy in European area from early twenty century. It is currently used as alternative anti-cancer remedy by...
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Developmental Differences in NMDA Neurototoxicity and the Expression of NMDA Receptor 2B Subunit of Rat Hippocampus

Youn YC, Park TH, Kwon OS, Chae SA, Lee CS

  • KMID: 2343256
  • J Korean Neurol Assoc.
  • 2007 Aug;25(3):364-371.
BACKGROUND: The developing brain has a distinctive set of characteristics that make it have different susceptibility to excitotoxins. Using primary tissue cultures of rat hippocampus, we investigated the developmental susceptibility...
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Analysis of the NF-kappaB and Apoptosis Inducing Genes in Bladder Tumor

Jung P, Han KH, Yun SJ, Kim YJ, Lee SC, Lee HL, Kim WJ

PURPOSE: A multi-subunit transcription factor NF-kappaB mediates the antiapoptotic signals in several cancer cell lines and it is activated in a broad range of human tumors. In this study, we...
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Mycophenolic Acid Induced Apoptotic Signal Transduction in Molt-4 T-cells

Choi SJ, Chung SY, Kim SK

  • KMID: 2004711
  • J Korean Surg Soc.
  • 2002 Jan;62(1):8-17.
PURPOSE: Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), is the active metabolite of the immunosuppressive drug, mycophenolate mofetil (MMF). MMF is used to prevent an immune-...
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The Expression of Hydroxyurea Induced Apoptosis Associated Proteins on Chronic Myelogenous Leukemic K562 Cells

Lee YJ, Park DS, Cho JH

  • KMID: 2089662
  • Korean J Clin Pathol.
  • 2001 Apr;21(2):98-103.
BACKGROUND: Hydroxyurea is used to decrease leukocyte count effectively in chronic myelogenous leukemia. We found that hydroxyurea induced apoptosis on the K562 cells via externalization of phosphatidylserine, activation of some...
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Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells

Lee SH, Choi JG, Cho MH

Nickel compounds are carcinogenic to human and are potent inducers of kidney and lung tumors in experimental animals. In this study, the effects of nickel(II) acetate on apoptosis, cell cycle...
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Topographic expression of p21WAF1/SDI1/CIP1, bcl2, and p53 is altered at the early stage of colorectal carcinogenesis

Cho JH, Roe IH, Lim CY, Park DK, Kim WH, Kim YI

We analyzed the expression of p21, bcl2, and p53 in normal and different pathologic mucosa of the human colorectum using immunohistochemistry and cold polymerase chain reaction-single strand conformation polymorphism. The topography...
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