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Local Drug Delivery Strategies for Glioblastoma Treatment

Cha GD, Jung S, Choi SH, Kim DH

Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason for the limited efficacy of standard treatment is the high recurrence rate of GBM, even after...
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Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction

Wei L, Singh R, Ghoshal UC

  • KMID: 2531182
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):357-375.
  • doi: 10.5056/jnm22008
Disorders of gut-brain interaction (DGBIs) are common conditions in community and clinical practice. As specialized enteroendocrine cells, enterochromaffin (EC) cells produce up to 95% of total body serotonin and coordinate...
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Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor–Toll-like Receptor 4–Proinflammatory Cytokine Signaling

Nozu T, Okumura T

  • KMID: 2528032
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):173-184.
  • doi: 10.5056/jnm21002
Irritable bowel syndrome (IBS) displays chronic abdominal pain with altered defecation. Most of the patients develop visceral hypersensitivity possibly resulting from impaired gut barrier and altered gut microbiota. We previously...
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Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets

Kim J, Chun J, Ahn M, Jung K, Moon C, Shin T

Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals....
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Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes

Li X, Cai Y, Zhang Z, Zhou J

As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain...
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Therapeutic effects of stiripentol against ischemia-reperfusion injury in gerbils focusing on cognitive deficit, neuronal death, astrocyte damage and blood brain barrier leakage in the hippocampus

Shin MC, Lee TK, Lee JC, Kim HI, Park CW, Cho JH, Kim DW, Ahn JH, Won MH, Lee CH

Stiripentol is an anti-epileptic drug for the treating of refractory status epilepticus. It has been reported that stiripentol can attenuate seizure severity and reduce seizure-induced neuronal damage in animal models...
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Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood–Brain Barrier

Li QY, Lee JH, Kim HW, Jin GZ

Brain diseases and damages come in many forms such as neurodegenerative diseases, tumors, and stroke. Millions of people currently suffer from neurological diseases worldwide. While Challenges of current diagnosis and...
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Electroacupuncture ameliorates blood-brain barrier dysfunction in 5XFAD Alzheimer’s animal model

Cai M, Lee JH, Yang EJ

Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disease accompanied by aging, followed by memory impairment and cognitive decline. Although numerous attempts have been made to develop treatments for...
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Migrainous Infarction with Adjacent Cortical Enhancement

Yoon IH, Yun SH, Song YM

A 26-year old woman developed left homonymous superior quadrantanopia followed by severe pulsating headache with vomiting. Thereafter, she experienced recurrent left hemiparesis and paresthesia with or without headache. Brain magnetic...
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Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study

Ha IH, Lim C, Kim Y, Moon Y, Han SH, Moon WJ

Objective: This study aimed to determine whether there are regional differences in the blood-brain barrier (BBB) permeability of cognitively normal elderly participants and to identify factors influencing BBB permeability with...
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Blood-brain barrier dysfunction in ischemic stroke and diabetes: the underlying link, mechanisms and future possible therapeutic targets

Wicha P, Das S, Mahakkanukrauh P

Ischemic stroke caused by occlusion of cerebral artery is responsible for the majority of stroke that increases the morbidity and mortality worldwide. Diabetes mellitus (DM) is a crucial risk factor...
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Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption

Zhang Z, Zhang Q, Li F, Xin Y, Duan Z

The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithelial cells damage. Heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal...
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Blood-Brain Barrier Disruption in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Evaluation with Region-Based Quantification of Dynamic Contrast-Enhanced MR Imaging Parameters Using Automatic Whole-Brain Segmentation

Yoen H, Yoo RE, Choi SH, Kim E, Oh BM, Yang D, Hwang I, Kang KM, Yun TJ, Kim Jh, Sohn CH

Objective: This study aimed to investigate the blood-brain barrier (BBB) disruption in mild traumatic brain injury (mTBI) patients with post-concussion syndrome (PCS) using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging...
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The current status of cancer survivorship care and a consideration of appropriate care model in Korea

Ko HM, Kim JR, Lee JS

Purpose: Breast cancer patients with a human epidermal growth factor receptor 2 (HER2) enriched subtype are known to have higher rates of brain metastases (BM) than other patients. This study...
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The Efficacy and Safety of Zinc-alpha-2 Glycoprotein (ZAG) Containing Moisturizer in Atopic Dermatitis

Kim SM, Chu H, Lee KH, Park CO

  • KMID: 2508886
  • Korean J Dermatol.
  • 2020 Nov;58(9):575-582.
Background: Patients with atopic dermatitis (AD) are vulnerable to xerosis due to impaired skin barrier function, which makes moisturizing essential. Recently, zinc-alpha-2 glycoprotein (ZAG) has appeared to modulate the skin...
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Evaluation of Intestinal Epithelial Barrier Function in Inflammatory Bowel Diseases Using Murine Intestinal Organoids

Rallabandi HR, Yang H, Oh KB, Lee HC, Byun SJ, Lee BR

BACKGROUND: Intestinal organoids have evolved as potential molecular tools that could be used to study host-microbiome interactions, nutrient uptake, and drug screening. Gut epithelial barrier functions play a crucial role...
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Skin Barrier Dysfunction in the Scalp, Nails, and Lips in Patients with Atopic Dermatitis

Lee CY, Jeong KH, Shin MK

  • KMID: 2506583
  • Korean J Dermatol.
  • 2020 Sep;58(8):525-529.
Background: Atopic dermatitis is a chronic, inflammatory disease affecting the skin including the scalp, nails, and lips. One of the main pathogenesis of atopic dermatitis is skin barrier impairment. Transepidermal...
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Survey of Safety Regulation and Evaluation of the Shielding Facility for the Medical Linear Accelerator

Shin J, Shin DO, Choi SH, Kim JS, Kim DW

  • KMID: 2510111
  • Prog Med Phys.
  • 2020 Sep;31(S1):S62.
Purpose: Recent technologies of radiotherapy such as Intensity-modulated radiotherapy, Tomotherapy and Cyberknife had advantage of the faster and higher dose delivery to patient. The special consideration to design the facility...
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Telmisartan Inhibits TNFα-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells

Jang C, Kim J, Kwon Y, Jo SA

Telmisartan is an angiotensin-II receptor blocker and acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). Several studies have demonstrated that telmisartan ameliorates depression and memory dysfunction and...
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Underutilization of Hospital-based Cardiac Rehabilitation after Acute Myocardial Infarction in Korea

Kim SH, Ro Js, Kim Y, Leigh JH, Kim WS

Background: Cardiac rehabilitation (CR) after acute myocardial infarction (AMI) is recommended as a mandatory intervention in several national clinical practice guidelines published in America, Europe, and Korea to reduce recurrence...
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