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Differentiation Syndrome with Ocular Manifestations in Acute Promyelocytic Leukemia Patients Treated with All-trans Retinoic Acid

Oh SE, Choi SY

Purpose: To report a rare case of differentiation syndrome with ocular manifestations in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid (ATRA). Case summary: A 27-year-old female complained...
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All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells

Kim Y, Jeung HK, Cheong JW, Song J, Bae SH, Lee JI, Min YH

Purpose: Pharmacological inhibition of mutant isocitrate dehydrogenase (IDH) reduces R-2-hydroxyglutarate (2-HG) levels and restores cellular differentiation in vivo and in vitro. The IDH2 inhibitor enasidenib (AG-221) has been approved by...
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Differentiation of human male germ cells from Wharton's jelly-derived mesenchymal stem cells

Dissanayake D, Patel H, Wijesinghe P

OBJECTIVE: Recapitulation of the spermatogenesis process in vitro is a tool for studying the biology of germ cells, and may lead to promising therapeutic strategies in the future. In this...
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The Bromodomain Inhibitor JQ1 Enhances the Responses to All-trans Retinoic Acid in HL-60 and MV4-11 Leukemia Cells

Kang C, Kim CY, Kim HS, Park SP, Chung HM

All-trans retinoic acid (ATRA) is a highly effective treatment for acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML). However, ATRA-based treatment is not effective in...
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Retinoic Acid Syndrome and Pseudotumor Cerebri in Patients with Acute Promyelocytic Leukemia

Kim JH, Shin YT, Park DH, Kim IT, Shin JP

PURPOSE: To report cases of a retinal, preretinal and vitreous hemorrhage due to retinoic acid syndrome and a papilledema caused by increased intracranial pressure in patients with acute promyelocytic leukemia...
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Characteristics and Therapeutic Outcomes of Acute Promyelocytic Leukemia in Children and Adolescents

Kim G, Lee HO, Choi JS, Baek HJ, Kook H

BACKGROUND: Acute promyelocytic leukemia (APL) is rare in children, accounting for 5-7% of all acute myeloid leukemia (AML) cases. This study aimed to review clinical and laboratory characteristics of pediatric...
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All-Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy

Kim CS, Park JS, Ahn CW, Kim KR

PURPOSE: The aim of this study was to examine the effects of all-trans retinoic acid (ATRA) on diabetic nephropathy. MATERIALS AND METHODS: We measured amounts of urinary albumin excretion (UAE) after...
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Effect of Retinoic Acid in a Mouse Model of Allergic Rhinitis

Son HL, Park HR, Park YJ, Kim SW

PURPOSE: All-trans retinoic acid (ATRA) modulates immune responses by affecting T cells. Several studies have revealed that allergic inflammation of the lower airways is negatively associated with the vitamin A...
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Current routine practice and clinico-pathological characteristics associated with acute promyelocytic leukemia in Korea

Ahn S, Park JS, Jeong SH, Lee HW, Park JE, Kim MH, Kim YS, Lee HS, Park TS, You E, Rheem I, Park J, Huh JY, Kang MS, Cho SR

BACKGROUND: Acute promyelocytic leukemia (APL) can be life threatening, necessitating emergency therapy with prompt diagnosis by morphologic findings, immunophenotyping, cytogenetic analysis, or molecular studies. This study aimed to assess the...
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Catalase Induced by All-Trans Retinoic Acid Is Involved in Antiproliferation of 36B10 Cells

Park WY, Yu JR

PURPOSE: All-trans retinoic acid (ATRA) has antiproliferative effects against brain tumor cells. Recently, ATRA has been reported to induce catalase. We investigated whether catalase induction by ATRA is associated with...
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All-trans Retinoic Acid-induced Nephrotic-range Proteinuria in a Patient with Acute Promyelocytic Leukemia

Lim SU, Lee SR, Seo SR, Ahn JS, Kim YK, Yang DH, Lee JJ, Kim HJ

All-trans retinoic acid (ATRA) is a potent differentiating agent for the treatment of acute promyelocytic leukemia (APL). Although ATRA is generally well-tolerated, some patients develop side effects, the most severe...
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Salvage treatments with all-trans retinoic acid and arsenic trioxide-based regimens in acute promyelocytic leukemia

Cho YY, Kim JG, Chae YS, Moon JH, Ahn BM, Sohn SK

  • KMID: 2256190
  • Korean J Med.
  • 2008 Jun;74(6):596-604.
BACKGROUND/AIMS: Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia with a specific clinical and molecular presentation. Treatment of acute promyelocytic leukemia with all-trans retinoic acid or arsenic...
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Remission induction using arsenic trioxide in acute promyelocytic leukemia

Min CK

  • KMID: 2256189
  • Korean J Med.
  • 2008 Jun;74(6):593-595.
In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (ATO) generates partial differentiation and apoptosis. Standard initial treatment for patients with APL consists of...
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Low-dose All-trans Retinoic Acid for Remission Induction of Acute Promyelocytic Leukemia in Acute Renal Failure

Park HW, Choi JH, Lee D, Koo DH, Koo JE, Kim SH, Lee JH, Lee JH, Lee KH

All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Renal involvement sometimes necessitates a dose reduction or discontinuation of induction therapy for hematological malignancies. We...
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All-trans Retinoic Acid induced Myositis in a Patient with Acute Promyelocytic Leukemia

Koh YS, Lee S, Kim YJ, Kim J, Hong SI, Park YH, Kim HJ, Kim DW, Lee JW, Min WS, Kim CC

  • KMID: 2252407
  • Korean J Hematol.
  • 2003 Aug;38(3):191-194.
Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation t(15;17), which fuses the promyelocytic leukemia (PML) gene to the retinoic acid receptor alpha (RARalpha) gene, and by a...
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Effects of All-Trans Retinoic Acid on the Laminin 1 Expression in Rat Hair Follicles

Lee YJ, Hwang SH, Lew JM, Jeong HS

  • KMID: 2322560
  • J Korean Soc Plast Reconstr Surg.
  • 2002 Sep;29(5):455-463.
Laminins, a subset of glycoproteins, are main components of the basement membrane along with fibronectin, type IV collagen, and heparan sulfate proteoglycan and influence the biologic features, such as growth...
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Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents

Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ

  • KMID: 938874
  • Exp Mol Med.
  • 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly...
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Sweet's syndrome during the treatment of acute promyelocytic leukemia with all-trans retinoic acid

Park CJ, Bae YD, Choi JY, Heo PS, Lee KS, Park YS, Lee JA

  • KMID: 759563
  • Korean J Intern Med.
  • 2001 Sep;16(3):218-221.
All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Quite many ATRA-related side effects, including retinoic acid syndrome, were reported. So far, it has rarely...
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Fcr Receptor and Mac-1 Expression and Functional Differentiation of HL-60 Cells by All-trans Retinoic Acid

Kim HS, Kim KH, Kim GH, Seoh JY

  • KMID: 2142388
  • J Korean Pediatr Soc.
  • 1999 Apr;42(4):462-471.
PURPOSE: During differentiation of HL-60 cells by all-trans retinoic acid(ATRA), we analyzed the expression of Fcr receptors and Mac-1 by molecules of equivalent soluble fluorochromes(MESF) and functional studies. METHODS: HL-60...
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The Effect of Retinoids in Medulloblastoma Cell Culture

Yoon SH, Kim JY, Park SW, Ahn YH, Ahn YM, Cho KH, Cho KG

  • KMID: 2188573
  • J Korean Neurosurg Soc.
  • 1999 Dec;28(12):1773-1781.
The retinoic acid, one of the most popular agents for chemoprevention can inhibit the proliferation of many cancer cells including neuroblastoma and glioblastoma but there is increasing demand reaccessing its...
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