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Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1

Gao S, Guo T, Luo S, Zhang Y, Ren Z, Lang X, Hu G, Zuo D, Jia W, Kong D, Yu H, Qiu Y

Chronic myeloid leukemia (CML) is a slowly progressing hematopoietic cell disorder. Sphingosine kinase 1 (SPHK1) plays established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of...
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