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Current Molecular Imaging Positron Emitting Radiotracers in Oncology

Zhu A, Shim H

  • KMID: 2051988
  • Nucl Med Mol Imaging.
  • 2011 Mar;45(1):1-14.
Molecular imaging is one of the fastest growing areas of medical imaging. Positron emission tomography (PET) has been widely used in the clinical management of patients with cancer. Nuclear imaging...
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Structural Requirements for Modulating 4-Benzylpiperidine Carboxamides from Serotonin/Norepinephrine Reuptake Inhibitors to Triple Reuptake Inhibitors

Paudel S, Kim E, Zhu A, Acharya S, Min X, Cheon SH, Kim KM

In this study, we determined the effect of 24 different synthetic 4-benzylpiperidine carboxamides on the reuptake of serotonin, norepinephrine, and dopamine (DA), and characterized their structure–activity relationship. The compounds with...
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Structure–Activity Relationship and Evaluation of Phenethylamine and Tryptamine Derivatives for Affinity towards 5-Hydroxytryptamine Type 2A Receptor

Wang S, Zhu A, Paudel S, Jang CG, Lee YS, Kim KM

Among 14 subtypes of serotonin receptors (5-HTRs), 5-HT 2AR plays important roles in drug addiction and various psychiatric disorders. Agonists for 5-HT 2AR have been classified into three structural groups:...
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Potential Functional Role of Phenethylamine Derivatives in Inhibiting Dopamine Reuptake: Structure–Activity Relationship

Kundu D, Zhu A, Kim E, Paudel S, Jang CG, Lee YS, Kim KM

Numerous psychotropic and addictive substances possess structural features similar to those of β-phenethylamine (β-PEA). In this study, we selected 29 β-PEA derivatives and determined their structure–activity relationship (SAR) to their...
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Role of high-frequency ultrasound in differentiating benign and malignant skin lesions: potential and limitations

Wang Q, Ren W, Wang L, Li X, Zhu A, Shan D, Wang J, Zhao Y, Li D, Ren TT, Guo L, Xu H, Sun L

Purpose: This study examined the diagnostic value of high-frequency ultrasound (HFUS) features in differentiating between benign and malignant skin lesions. Methods: A total of 1,392 patients with 1,422 skin lesions who...
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Potential Biomarker of L-type Amino Acid Transporter 1 in Breast Cancer Progression

Liang Z, Cho HT, Williams L, Zhu A, Liang K, Huang K, Wu H, Jiang C, Hong S, Crowe R, Goodman MM, Shim H

  • KMID: 2313132
  • Nucl Med Mol Imaging.
  • 2011 Jun;45(2):93-102.
PURPOSE: L-type amino acid transporter 1 (LAT1) is essential for the transport of large neutral amino acids. However, its role in breast cancer growth remains largely unknown. The purpose of...
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