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Art of replacing craniofacial bone defects

Rah DK

In the history of medicine, many surgeons have been tried to reconstruct lost tissue and correct deformity, attempts to use implant materials have probably paralleled those involving autogenous tissue. Recently...
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Tissue-engineered human living skin substitutes: development and clinical application

Lee KH

The skin acts as a barrier to exogenous substances, pathogens, and trauma. Skin defects caused by burns, venous ulcer, diabetic ulcer, or acute injury occasionally induce life-threatening situations. Tissue engineering...
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Viability evaluation of engineered tissues

Park JC, Hwang YS, Suh H

Biohybrid artificial organs encompass all devices capable of substituting for an organ or tissue function and are fabricated from both synthetic materials and living cells. The viability of engineered tissue...
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Tissue engineering applications in the genitourinary tract system

Yoo JJ, Atala A

The concept of cell transplantation using tissue engineering techniques has provided numerous possibilities in the area of urologic tissue reconstruction. Tissue engineering applications in the genitourinary tract system have been...
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An overview of cartilage tissue engineering

Kim HW, Han CD

Articular cartilage regeneration refers to the formation of new tissue that is indistinguishable from the native articular cartilage with respect to zonal organization, biochemical composition, and mechanical properties. Due to...
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Tissue restoration, tissue engineering and regenerative medicine

Suh H

Recently, thanks to the rapid progress of new technologies in cell modulation, extracellular matrix fabrication and synthetic polymers mimicking bodily structures, the self-regeneration of bodily defects by host tissue has...
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Transplantation of neural stem cells: cellular & gene therapy for hypoxic-ischemic brain injury

Park KI

We have tracked the response of host and transplanted neural progenitors or stem cells to hypoxic-ischemic (HI) brain injury, and explored the therapeutic potential of neural stem cells (NSCs) injected...
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Biodegradable poly (lactic acid) microspheres for drug delivery systems

Hyon SH

In connection with aim of maximizing the bio-availability of conventional drugs with minimum side-effects, new drug delivery systems (DDS) continue to attracted much attention. The controlled or sustained release of...
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Cytokine delivery and tissue engineering

Lee SJ

Tissue engineering has been applied to various tissues, and particularly significant progress has been made in the areas of skin, cartilage, and bone regeneration. Inclusion of bioactive factors into the...
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Tissue engineering a blood vessel substitute: the role of biomechanics

Nerem RM

The engineering of a functional blood vessel substitute has for a quarter of a century been a "holy grail" within the cardiovascular research community. Such a substitute must exhibit long...
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Re-Engineering the liver with natural biomaterials

Gupta S, Malhi H, Gorla GR

The extensive regenerative capacity of hepatocytes and the key roles of the liver in metabolic processes have generated interest in the liver as an appropriate target for cell and gene...
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Cellular signaling in tissue regeneration

Kim WJ

With recent progress in stem cell-based research, there has been tremendous interest in stem cell-based tissue regeneration. Stem cells can be differentiated into specialized cells/tissues by growth factors and cytokines....
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Tissue engineering in the twenty-first century

Terada S, Sato M, Sevy A, Vacanti JP

In the 20th century, free tissue transfers have been successfully introduced using microvascular anastomosis techniques. Transplants not only include whole organs such as the kidney, liver and lung, but also...
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Tissue engineering of urinary organs

Park KD, Kwon IK, Kim YH

Tissue engineering can serve as an alternative treatment for a malfunctioning or lost organ. Isolated and expanded cells adhere to a temporary scaffold, proliferate, and secrete their own extracellular...
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Temperature-Responsive surface for novel co-culture systems of hepatocytes with endothelial cells: 2-D patterned and double layered co-cultures

Hirose M, Yamato M, Kwon OH, Harimoto M, Kushida A, Shimizu T, Kikuchi A, Okano T

We have developed two novel cell co-culture system, without any on cell type combination limitation, utilizing a polymer surface which is temperature-sensitive with respect to its cell adhesion characteristics. One...
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In vitro model of atherosclerosis using coculture of arterial wall cells and macrophage

Wada Y, Sugiyama A, Kohro T, Kobayashi , Takeya M, Naito M, Kodama T

In order to determine the precise mechanism of the interactions between different types of cells, which are common phenomena in tissues and organs, the importance of coculture techniques are becoming...
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