- Bioactive Lysophosphatidylcholine 16:0 and 18:0 Are Elevated in Lungs of Asthmatic Subjects
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Yoder M, Zhuge Y, Yuan Y, Holian O, Kuo S, van Breemen R, Thomas LL, Lum H
- KMID: 2166937
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):61-65.
- doi: 10.4168/aair.2014.6.1.61
PURPOSE: Asthma is a chronic inflammatory disease of the airways, and is associated with upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine, producing lysophosphatidylcholine (LPC) and free fatty... -
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- Stimulated Bronchial Epithelial Cells Release Bioactive Lysophosphatidylcholine 16:0, 18:0, and 18:1
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Zhuge Y, Yuan Y, van Breemen R, DeGrand M, Holian O, Yoder M, Lum H
- KMID: 2166940
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):66-74.
- doi: 10.4168/aair.2014.6.1.66
PURPOSE: In human subjects and animal models with acute and chronic lung injury, the bioactive lysophosphatidylcholine (LPC) is elevated in lung lining fluids. The increased LPC can promote an inflammatory... -
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