- Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
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Zhao D, Gu MY, Xu JL, Zhang LJ, Ryu SY, Yang HO
- KMID: 2432072
- Biomol Ther.
- 2019 Jan;27(1):92-100.
- doi: 10.4062/biomolther.2018.104
Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this... -
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- 3’-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-DXylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells
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Lee SB, Park A, Ma CT, Kim YH, Yang HO
- KMID: 2515277
- Biomol Ther.
- 2021 May;29(3):290-294.
- doi: 10.4062/biomolther.2020.195
Extracellular beta amyloid (Aβ) plaques are the neuropathological hallmarks of Alzheimer’s disease (AD). Accordingly, reducing Aβ levels is considered a promising strategy for AD prevention. 3’-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside significantly decreased the Aβ... -
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- Detection of Antibodies against Shope Fibroma Virus and Formation of Fibroma in the Korean Domestic Rabbits
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Yang HO, Park KK, Ryu SJ, Woo YD, Joo YK, Lee HW
- KMID: 2096720
- J Korean Soc Virol.
- 1998 Dec;28(4):369-375.
In our preliminary study to find antiviral or antitumor agents from Korean natural products, we found that the Shope fibroma virus (SFV) induced fibromas reaching maximum size at 5~6 days... -
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- Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson’s Disease Model
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Lee SB, Yang HO
- KMID: 2532873
- Biomol Ther.
- 2022 Sep;30(5):409-417.
- doi: 10.4062/biomolther.2022.020
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, and accumulating evidence indicates that mitochondrial dysfunction is associated with progressive deterioration in PD patients. Previous studies have shown... -
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- Sinapic Acid Attenuates the Neuroinflammatory Response by Targeting AKT and MAPK in LPS-Activated Microglial Models
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Huang T, Zhao D, Lee S, Keum G, Yang HO
- KMID: 2541786
- Biomol Ther.
- 2023 May;31(3):276-284.
- doi: 10.4062/biomolther.2022.092
Sinapic acid (SA) is a phenolic acid that is widely distributed in fruits and vegetables, which has various bioactivities, such as antidiabetic, anticancer and anti-inflammatory functions. Over-activated microglial is involved... -
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- Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein
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Chun YS, Kwon OH, Oh HG, Cho YY, Yang HO, Chung S
- KMID: 2447854
- Biomol Ther.
- 2019 May;27(3):276-282.
- doi: 10.4062/biomolther.2018.112
β-amyloid precursor protein (APP) can be cleaved by α-, and γ-secretase at plasma membrane producing soluble ectodomain fragment (sAPPα). Alternatively, following endocytosis, APP is cleaved by β-, and γ-secretase at... -
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- The Pharmacokinetic Interaction and Therapeutic Plasma Concentration of Oxcarvazepine
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Kang JK, Yang HO, Park SY, Jeong YH, Kwak KH, Lee SA
- KMID: 1816453
- J Korean Epilepsy Soc.
- 1999 Dec;3(2):200-205.
PURPOSE: Oxcarbazepine (OXC) is chemically related to carbamazepine (CBZ). OZC exerts less liver enzyme induction than CBZ and is completely metabolized by reduction to the active metabolite, 10, 11-dihydro-10-hydroxy-5H-dibenzo (b,f)... -
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- Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells
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Kim HJ, Kim J, Kang KS, Lee KT, Yang HO
- KMID: 2170619
- Biomol Ther.
- 2014 Jul;22(4):275-281.
Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome.... -
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- Neuroprotective Effect of Astersaponin I against Parkinson’s Disease through Autophagy Induction
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Zhang L, Park JY, Zhao D, Kwon HC, Yang HO
- KMID: 2522249
- Biomol Ther.
- 2021 Nov;29(6):615-629.
- doi: 10.4062/biomolther.2021.004
An active compound, triterpene saponin, astersaponin I (AKNS-2) was isolated from Aster koraiensis Nakai (AKNS) and the autophagy activation and neuroprotective effect was investigated on in vitro and in vivo... -
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