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The impact of short-course total neoadjuvant therapy, long-course chemoradiotherapy, and upfront surgery on the technical difficulty of total mesorectal excision: an observational study with an intraoperative perspective

Chong CXZ, Koh FH, Tan HL, Sivarajah SS, Ng JL, Ho LML, Aw DKL, Koo WH, Han S, Koo SL, Yip CSP, Wang FQ, Foo FJ, Tan WJ

Purpose: Total neoadjuvant therapy (TNT) is becoming the standard of care for locally advanced rectal cancer. However, surgery is deferred for months after completion, which may lead to fibrosis and...
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