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Hepatitis C virus: virology and life cycle

Kim CW, Chang KM

Hepatitis C virus (HCV) is a positive sense, single-stranded RNA virus in the Flaviviridae family. It causes acute hepatitis with a high propensity for chronic infection. Chronic HCV infection can...
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The prediction of interferon-alpha therapeutic effect by sequence variation of the HCV hypervariable region 1

Yeh BI, Kim HW, Kim HS, Lee JY, Lee KH, Lee KM, Kim JS, Han KH

Interferon-alpha (IFN-alpha) has been used to treat hepatitis C virus (HCV)-induced hepatitis, but it has been effective in only about half of the treated patients, with recurrence appearing in the...
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Molecular characterization of a 13-amino acid deletion in VP1 (1D) protein and novel amino acid substitutions in 3D polymerase protein of foot and mouth disease virus subtype A/Iran87

Esmaelizad M, Jelokhani-Niaraki S, Hashemnejad K, Kamalzadeh M, Lotfi M

The nucleotide sequence of the VP1 (1D) and partial 3D polymerase (3Dpol) coding regions of the foot and mouth disease virus (FMDV) vaccine strain A/Iran87, a highly passaged isolate (~150...
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Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells

Choi HB, Kim YG, Oh JW

  • KMID: 1119328
  • Exp Mol Med.
  • 2003 Dec;35(6):475-485.
The hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B protein, is the key viral enzyme responsible for replication of the HCV viral RNA genome. Although several full-length and truncated forms...
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