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Effects of Calcium Channel Blockers and Insulin on the Platelet Function in Patients with Diabetes Mellitus

Lee YS, Hahm KS, Lee SY

Platelet aggregability was compared between platelets isolated from normal subjects and patients with diabetes mellitus in order to evaluate the effects of calcium channel blockers and insulin on the platelet...
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Involvement of throm box aneA2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation

Rasheed H, Saeed SA

  • KMID: 1097103
  • Exp Mol Med.
  • 2004 Jun;36(3):220-225.
The present study was carried out to examine the mechanisms of the synergistic interaction of PAF and A23187 mediated platelet aggregation. We found that platelet aggregation mediated by subthreshold concentrations...
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Cardioprotective drugs decrease the Na+ background current

Park SR, Ryu GH, Suh CK

Cardiac dysfunctions such as myocardial functional failure and ventricular arrhythmia have been largely attributed to intracellular Ca2+ overload. One of the mechanisms of intracellular Ca2+ overload involves a rapid influx...
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Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.

Shah BH, Rasheed H, Rahman IH, Shariff AH, Khan FL, Rahman HB, Hanif S, Saeed SA

  • KMID: 1457534
  • Exp Mol Med.
  • 2001 Dec;33(4):226-233.
Our recent studies have shown that co-activation of Gq and Gi proteins by 5-hydroxytryptamine (5-HT) and adrenaline show synergism in human platelet aggregation. This study was conducted to examine the...
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Mechanism of UV light-induced photorelaxation in isolated rat aorta

Kim JH, Hong Y, Shim CS

  • KMID: 1094645
  • J Vet Sci.
  • 2000 Dec;1(2):81-86.
Isolated rat thoracic aorta which is pharmacologically precontracted by phenylephrine induces photorelaxation when exposed to long wave length UV-light. The aim of the present study was to characterize the mechanism...
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Effects of hypoxia on pulmonary vascular contractility

Lee YH, Seo JH, Kang BS

Although hypoxic pulmonary vasoconstriction (HPV) has been recognized by many researchers, the precise mechanism remains unknown. As isolated pulmonary arteries will constrict in vitro in the response to hypoxia, the...
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