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Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications

Parlikar R, Bose A, Venkatasubramanian G

Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action....
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Neuroimmunological Aberrations and Cerebral Asymmetry Abnormalities in Schizophrenia: Select Perspectives on Pathogenesis

Venkatasubramanian G, Debnath M

  • KMID: 2171124
  • Clin Psychopharmacol Neurosci.
  • 2014 Apr;12(1):8-18.
Within the wide-ranging gamut of factors that comprise gene-environment interactions postulated to underlie schizophrenia, the crosstalk between environmental factors and feto-maternal immune components has been put forth as one of...
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Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives

Venkatasubramanian G

From neurophenomenological perspectives, schizophrenia has been conceptualized as "a disorder with heterogeneous manifestations that can be integrally understood to involve fundamental perturbations in consciousness". While these theoretical constructs based on...
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A Functional Domain Based Approach in Neurocognitive Rehabilitation with Transcranial Direct Current Stimulation: A Case Report

Sreeraj VS, Shivakumar V, Bose A, Abhiram PN, Agarwal SM, Chhabra H, Narayanaswamy JC, Venkatasubramanian G

Transcranial direct current stimulation (tDCS) is a novel brain stimulation technique which has kindled hope in alleviating motor, language as well as cognitive deficits in neuronal injury. Current case report...
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A Primer on Interoception and its Importance in Psychiatry

Nayok SB, Sreeraj VS, Shivakumar V, Venkatasubramanian G

Interoception is the perception of signals from inside the body. It plays a significant role in the nervous, cardiovascular, respiratory, gastrointestinal, genitourinary, and endocrine systems. It is also closely related...
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Transcranial Direct Current Stimulation in Schizophrenia

Agarwal SM, Shivakumar V, Bose A, Subramaniam A, Nawani H, Chhabra H, Kalmady SV, Narayanaswamy JC, Venkatasubramanian G

  • KMID: 2171144
  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):118-125.
Transcranial direct current stimulation (tDCS) is an upcoming treatment modality for patients with schizophrenia. A series of recent observations have demonstrated improvement in clinical status of schizophrenia patients with tDCS....
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Needs of Siblings of Persons with Psychosis: A Systematic Descriptive Review

Amaresha A, Venkatasubramanian G, Muralidhar D

  • KMID: 2279942
  • Clin Psychopharmacol Neurosci.
  • 2014 Aug;12(2):111-123.
Research on caregivers of psychosis has predominantly focused on parents and spouses. Issues related to siblings of persons with psychosis (SOPP) are yet to be evaluated comprehensively. Like parents and...
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Pars Triangularis Volume Asymmetry and Schneiderian First Rank Symptoms in Antipsychotic-naïve Schizophrenia

Shivakumar V, Sreeraj VS, Kalmady SV, Gangadhar BN, Venkatasubramanian G

Objective: Schizophrenia is a disorder of language and self, with first-rank symptoms (FRS) as one of the predominant features in a subset of patients. Abnormal language lateralization is hypothesized to...
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Multiple Complement Pathway-related Proteins Might Regulate Immunopathogenesis of Major Depressive Disorder

Reddy PV, Talukdar PM, Subbanna M, Bhargav PH, Arasappa R, Venkatasubramanian G, Muralidharan K, Debnath M

Objective: Exacerbated inflammatory pathway has emerged as a predominant etiological construct of major depressive disorder (MDD). Innate immune molecules like complement proteins induce inflammatory responses and also regulate key neurobiological...
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Brain Functional Magnetic Resonance Imaging Cue-reactivity Can Predict Baclofen Response in Alcohol Use Disorders

Holla B, Karthik S, Biswal J, Viswanath , Jayarajan , Bharath RD, Venkatasubramanian G, Benegal V

OBJECTIVE: Baclofen is a promising treatment for alcohol use disorders (AUD), although its clinical response in humans is mixed. The present study aimed at investigating the impact of baclofen treatment...
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Neural Correlates of a Perspective-taking Task Using in a Realistic Three-dimmensional Environment Based Task: A Pilot Functional Magnetic Resonance Imaging Study

Agarwal SM, Shivakumar V, Kalmady SV, Danivas V, Amaresha A, Bose A, Narayanaswamy JC, Amorim MA, Venkatasubramanian G

OBJECTIVE: Perspective-taking ability is an essential spatial faculty that is of much interest in both health and neuropsychiatric disorders. There is limited data on the neural correlates of perspective taking...
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A Longitudinal Study of Relation between Side-effects and Clinical Improvement in Schizophrenia: Is There a Neuro-metabolic Threshold for Second Generation Antipsychotics?

Venkatasubramanian G, Rao NP, Arasappa R, Kalmady SV, Gangadhar

  • KMID: 2171193
  • Clin Psychopharmacol Neurosci.
  • 2013 Apr;11(1):24-27.
OBJECTIVE: Classical studies demonstrated Neuroleptic Induced Extrapyramidal Side-effects (NIES; Neuroleptic threshold) to correlate with the efficacy of first generation antipsychotics. Second generation antipsychotics (SGAs), in addition to the extrapyramidal side...
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In Silico Model-driven Assessment of the Effects of Brain-derived Neurotrophic Factor Deficiency on Glutamate and Gamma-Aminobutyric Acid: Implications for Understanding Schizophrenia Pathophysiology

Agrawal R, Kalmady SV, Venkatasubramanian G

OBJECTIVE: Deficient brain-derived neurotrophic factor (BDNF) is one of the important mechanisms underlying the neuroplasticity abnormalities in schizophrenia. Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate...
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