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Long-term HbA1c Variability and Treatment Outcomes of Intravitreal Injection in Diabetic Macular Edema

An Y, Park SP, Kim YK

Purpose: To evaluate the association between long-term glycated hemoglobin A (HbA1c) variability and treatment outcomes ofanti-vascular endothelial growth factor (VEGF) injection in diabetic macular edema patients. Methods: The medical records of...
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The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer

Goulart A, Ferreira C, Rodrigues , Coimbra B, Sousa N, Leão P

PURPOSE: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer...
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Angiopoietin-1 and -2 and vascular endothelial growth factor expression in ovarian grafts after cryopreservation using two methods

Cho IA, Lee YJ, Lee HJ, Choi IY, Shin JK, Lee SA, Lee JH, Choi WJ

OBJECTIVE: The favored method of preserving fertility in young female cancer survivors is cryopreservation and autotransplantation of ovarian tissue. Reducing hypoxia until angiogenesis takes place is essential for the survival...
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Pathophysiology of Diabetic Retinopathy: The Old and the New

Kusuhara S, Fukushima , Ogura S, Inoue N, Uemura A

Vision loss in diabetic retinopathy (DR) is ascribed primarily to retinal vascular abnormalities—including hyperpermeability, hypoperfusion, and neoangiogenesis—that eventually lead to anatomical and functional alterations in retinal neurons and glial cells....
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Anti-angiogenic Therapy in Patients with Advanced Gastric and Gastroesophageal Junction Cancer: A Systematic Review

Chen LT, Oh DY, Ryu MH, Yeh KH, Yeo W, Carlesi R, Cheng R, Kim J, Orlando M, Kang YK

Despite advancements in therapy for advanced gastric and gastroesophageal junction cancers, their prognosis remains dismal. Tumor angiogenesis plays a key role in cancer growth and metastasis, and recent studies indicate...
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Prevention and management of diabetic retinopathy

Song JH

Diabetic retinopathy(DR) is the leading cause of new onset blindness among working-aged groups in industrialized countries, and its incidence is expected to increase along with the rising incidence of diabetes...
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The Effects of Polydeoxyribonucleotide on the Survival of Random Pattern Skin Flaps in Rats

Chung KI, Kim HK, Kim WS, Bae TH

BACKGROUND: Partial or complete necrosis of a skin flap is a common problem. Polydeoxyribonucleotide (PDRN) can be extracted from trout sperm and used as a tissue repair agent. The aim...
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The discovery of placenta growth factor and its biological activity

De Falco S

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and...
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Vascular Endothelial Growth Factor Levels in Relation to Oxidative Damage and Antioxidant Status in Patients with Breast Cancer

Pande D, Negi R, Khanna S, Khanna R, Khanna HD

  • KMID: 2394770
  • J Breast Cancer.
  • 2011 Sep;14(3):181-184.
PURPOSE: Oxidative stress and angiogenesis are important elements in the pathogenesis of inflammatory diseases and cancer. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic cytokines and...
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Blockade of Vascular Endothelial Growth Factor (VEGF) Aggravates the Severity of Acute Graft-versus-host Disease (GVHD) after Experimental Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT)

Kim AR, Lim JY, Jeong DC, Park G, Lee BC, Min CK

BACKGROUND: Recent clinical observation reported that there was a significant correlation between change in circulating vascular endothelial growth factor (VEGF) levels and the occurrence of severe acute graft-versus-host disease (GVHD)...
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A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity

Kim JW, Kim TD, Hong BS, Kim OY, Yoon WH, Chae CB, Gho YS

Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for...
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Subconjunctival Bevacizumab as an Adjunct to Trabeculectomy in Eyes with Refractory Glaucoma: A Case Series

Choi JY, Choi J, Kim YD

This prospective observational case series study included 6 eyes of 6 consecutive glaucomatous patients. Each patient underwent trabeculectomy with mitomycin C, and received a 1.25 mg of subconjunctival bevacizumab injection...
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Differential Expression of Stem Cell Markers and Vascular Endothelial Growth Factor in Human Retinoblastoma Tissue

Kim M, Kim JH, Kim JH, Kim DH, Yu YS

PURPOSE: To investigate the relationship between vascular endothelial growth factor (VEGF) and the cancer stem cell-vascular niche complex in human retinoblastoma tissue. METHODS: Six human retinoblastoma specimens primarily enucleated for...
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Effects of Anti-Vascular Endothelial Growth Factor (VEGF) on Pancreatic Islets in Mouse Model of Type 2 Diabetes Mellitus

Kim JW, Ham DS, Park HS, Ahn YB, Song KH, Yoon KH, Yoo KD, Kim MJ, Jeong IK, Ko SH

BACKGROUND: Vascular endothelial growth factor (VEGF) is associated with the development of diabetic complications. However, it is unknown whether systemic VEGF treatment has any effects on the pancreatic islets in...
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Expression of VEGF, HGF, IL-6, IL-8, MMP-9, Telomerase in Peripheral Blood of Patients with Head and Neck Squamous Cell Carcinoma

Hong DY, Lee BJ, Lee JC, Choi JS, Wang SG, Ro JH

OBJECTIVES: This study investigated the telomerase expression in peripheral blood mononuclear cells (PBMCs) and the relationship between the serum level of several soluble factors such as vascular endothelial growth factor...
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Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Susceptibility and Clinicopathologic Characteristics of Colorectal Cancer

Chae YS, Kim JG, Sohn SK, Cho YY, Ahn BM, Moon JH, Jeon SW, Park JY, Lee IT, Choi GS, Jun SH

Since vascular endothelial growth factor (VEGF) is known to be a potent pro-angiogenic factor, we evaluated the potential association of two VEGF gene polymorphisms (-634G>C and 936C>T) with the susceptibility...
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Expression of vascular endothelial growth factor (VEGF) family members and prognosis after hepatic resection in HBV-related hepatocellular carcinoma

Moon JI, Kim JM, Jung GO, Chun JM, Choi GS, Park JB, Kwon CH, Kim SJ, Jo JW

BACKGROUND/AIMS: Human hepatocellular carcinoma (HCC) is a hypervascular tumor, and vascular endothelial growth factor (VEGF) plays a key role in the regulation of tumor-associated angiogenesis. In this study, we...
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Clinical significance of serum vascular endothelial growth factor in Kawasaki disease

Lee HS, Yun SW, Jung YS, Chae SA, Lim IS, Lee DK, Choi ES, Yoo BH, Lee MK

PURPOSE: Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in...
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Inhibition of Neointima Formation by Anti-Vascular Endothelial Growth Factor and Receptor-1 Peptides in a Balloon-Injured Rat Carotid Artery

Lee JM, Moon KW, Yoo KD, Her SH, Yoon HJ, Jin SW, Jeon DS, Youn HJ, Chung WS, Seung KB, Kim CM, Kim JH, Choi KB, Hong SJ

BACKGROUND AND OBJECTIVES: Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific mitogen. This study was undertaken to test the hypothesis that the neointima hyperplasia induced by a balloon...
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Penile Expression of Hypoxia-inducible Factor-1alpha, Vascular Endothelial Growth Factor, and Nitric Oxide Synthase in the Type II Diabetic Rat

Park HJ, Park BK, Park NC

  • KMID: 2226644
  • Korean J Androl.
  • 2005 Dec;23(3):144-152.
PURPOSE: Erectile dysfunction(ED) is commonly experienced in men with diabetes mellitus. Hypoxia in the penile tissue by vascular complications is regarded as a pathophysiologic factor in diabetic ED. The aim...
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