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Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes

Song HY, Ryu J, Ju SM, Park LJ, Lee JA, Choi SY, Park J

  • KMID: 1103678
  • Exp Mol Med.
  • 2007 Feb;39(1):27-37.
One of characteristic features of AIDS-related encephalitis and dementia is the infiltration of monocytes into the CNS. HIV-1 Tat was demonstrated to facilitate monocyte entry into the CNS. In this...
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Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity

Shen M, Zhang L, Lee KM, Vermeulen , Hosgood HD, Li G, Yin S, Rothman N, Chanock S, Smith MT, Lan Q

Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity...
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