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Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1

Song Y, Lee S, Kim JR, Jho EH

Ubiquitination of proteins plays an essential role in various cellular processes, including protein degradation, DNA repair, and cell signaling pathways. Previous studies have shown that protein ubiquitination is implicated in...
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Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control

Jung Y, Kim HD, Yang HW, Kim HJ, Jang CY, Kim J

When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have...
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