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Miliary Tuberculosis Associated with Klebsiella pneumonia: Managing the Double Whammy of Antimicrobial Resistance

Mishra P, Kondisetti M, Patil A, Sarangdhar N, Gupta V

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Diagnosis and Treatment of Latent Tuberculosis Infection in Adults in South Korea

Jo KW, Yoon YS, Kim HW, Kim JY, Kang YA, on Behalf of the Korean TB Guideline Development Committee

Latent tuberculosis infection (LTBI) is characterized by immune responses to Mycobacterium tuberculosis antigens without clinical symptoms or evidence of active tuberculosis. Effective LTBI management is crucial for tuberculosis elimination, requiring...
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Diagnostic Accuracy of BD MAX MDR-TB Assay Performed on Bronchoscopy Specimens in Patients with Suspected Pulmonary Tuberculosis

Ko SJ, Yoon KH

Background: Several novel molecular platforms using nucleic acid amplification tests have been developed for the diagnosis of pulmonary tuberculosis (PTB) and rapid detection of isoniazid and rifampin resistance. Among them,...
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Korean Guidelines for the Management and Antibiotic Therapy in Adult Patients with Hospital-Acquired Pneumonia

Choi H, Min KH, Lee YS, Chang Y, Lee BY, Oh JY, Baek AR, Lee J, Jeon K

Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are correlated with high morbidity and mortality rates. Guidelines that consider local epidemiologic data are fundamental for identifying optimal treatment strategies. However, Korea...
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Comprehensive Strategies for Preoperative Pulmonary Risk Evaluation and Management

Lee HJ, Lee HW

Postoperative pulmonary complications (PPCs) significantly increase morbidity and mortality in surgical patients, particularly those with pulmonary conditions. PPC incidence varies widely, influenced by factors such as surgery type, patient age,...
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Air Pollution and Interstitial Lung Disease

Jo YS, Song JW

This review article explores the multifaceted relationship between air pollution and interstitial lung diseases (ILDs), particularly focusing on idiopathic pulmonary fibrosis, the most severe form of fibrotic ILD. Air pollutants...
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Beyond the Spirometry: New Diagnostic Modalities in Chronic Obstructive Pulmonary Disease

Song JH, Kim Y

Spirometry can play a critical role as a gold standard in the diagnosis and treatment of patients with chronic obstructive pulmonary disease (COPD). While the criteria for diagnosis have advanced...
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Clinical Profiles of Multidrug-Resistant and Rifampicin-Monoresistant Tuberculosis in Korea, 2018–2021: A Nationwide Cross-Sectional Study

Min J, Ko Y, Kim HW, Koo HK, Oh JY, Jeon D, Lee T, Kim YC, Lim SC, Lee SS, Park JS, Kim JS

Background: This study aimed to identify the clinical characteristics of multidrug-resistant/ rifampicin-resistant tuberculosis (MDR/RR-TB) in the Republic of Korea. Methods: Data of notified people with tuberculosis between July 2018 and December...
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Dry Medical Thoracoscopy with Artificial Pneumothorax Induction Using Veress Needle

Huan NC, Kho SS, Nyanti LE, Ramarmuty HY, Rahim MAA, Ho RL, Lo SM, Tie ST, Kannan KKS

Background: In the absence of significant pleural effusion, conventional medical thoracoscopy (MT) is often not feasible due to the risk of lung injury. Dry MT mitigates these risks by inducing...
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Clinical Characteristics of Chronic Obstructive Pulmonary Disease according to Smoking Status

Park JH

Chronic obstructive pulmonary disease (COPD) can be caused by various factors, including lung infections, asthma, air pollution, childhood growth disorders, and genetic factors, though smoking is the predominant risk factor....
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Idiopathic Inflammatory Myopathies-Associated Interstitial Lung Disease in Adults

Moda M, Yanagihara T, Nakashima R, Sumikawa H, Shimizu S, Arai T, Inoue Y

Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune diseases characterized by muscle involvement and various extramuscular manifestations. Interstitial lung disease (ILD) is one of the most common extramuscular...
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High-Dose Rifampicin for 3 Months after Culture Conversion for Drug-Susceptible Pulmonary Tuberculosis

Kwak N, Kim JY, Kim HJ, Kwon BS, Lee JH, Mok J, Kwon YS, Kang YA, Park Y, Lee JY, Jeon D, Lee JK, Yang JS, Whang J, Kim KJ, Kim YR, Cheon M, Park J, Hahn S, Yim JJ

Background: This study aimed to determine whether a shorter high-dose rifampicin regimen is non-inferior to the standard 6-month tuberculosis regimen. Methods: This multicenter, randomized, open-label, non-inferiority trial enrolled participants with respiratory...
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Disease Severity and Activity in Bronchiectasis: A Paradigm Shift in Bronchiectasis Management

Im Y, Chalmers JD, Choi H

Bronchiectasis has an increasing prevalence and substantial clinical and economic burden. Therefore, physicians should identify patients with bronchiectasis at high risk of disease progression to ensure optimal management in advance....
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Association of Nutritional Intake with Physical Activity and Handgrip Strength in Individuals with Airflow Limitation

Heo IR, Kim TH, Jeong JH, Heo M, Ju SM, Yoo JW, Lee SJ, Cho YJ, Jeong YY, Lee JD, Kim HC

Background: We investigated whether nutritional intake is associated with physical activity (PA) and handgrip strength (HGS) in individuals with airflow limitation. Methods: This study analyzed data from the 2014 and 2016...
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Regenerative Capacity of Alveolar Type 2 Cells Is Proportionally Reduced Following Disease Progression in Idiopathic Pulmonary Fibrosis-Derived Organoid Cultures

Choi HK, Bang G, Shin JH, Shin MH, Woo A, Kim SY, Lee SH, Kim EY, Shim HS, Suh YJ, Kim HE, Lee JG, Choi J, Lee JH, Kim CH, Park MS

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease that culminates in respiratory failure and death due to irreversible scarring of the distal lung. While initially considered a...
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KEAP1-NRF2 Pathway as a Novel Therapeutic Target for EGFR-Mutant Non-small Cell Lung Cancer

Choi JS, Kang HM, Na K, Kim J, Kim TW, Jung J, Lim H, Seo H, Lee SH

Background: Kelch-like ECH-associated protein 1 (KEAP1)–nuclear factor erythroid- 2-related factor 2 (NRF2) pathway is a major regulator protecting cells from oxidative and metabolic stress. Studies have revealed that this pathway...
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