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Right Lung Mass

Kim J, Han M, Kim DH, Ko H, Lee YD, Cho Y

Sarcomatoid carcinomas of the lung are rare malignant biphasic tumors, which contain both a malignant epithelial component and a sarcomatoid component. The majority of patients are men and the mean...
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Role of PI3K/Akt Pathway in the Activation of IkappaB/NF-kappaB Pathway in Lung Epithelial Cells

Lee SM, Kim YK, Hwang YH, Lee CH, Lee HS, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG

BACKGROUND: NF-kappaB is a characteristic transcriptional factor which has been shown to regulate production of acute inflammatory mediators and to be involved in the pathogenesis of many inflammatory lung diseases....
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Gene Expression of Surfactant Protein B and C in Endotoxin and Thiourea Treated Rats

Sohn DH, Sohn JW, Yoon HJ, Shin DH, Park SS

BACKGROUND: The surfactant specific proteins, SP-B and SP-C are believed to be important regulators of the surfactant function and homeostasis. Since acute respiratory distress syndrome(ARDS) is usually viewed as the...
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Clinical Features in Patients with Amylase-Rich Pleural Effusion

Lee GD, Shin MK, Lee KW, Cho YJ, Kim HC, Hwang YS

BACKGROUND: Pleural effusions with high amylase levels are reported frequently in patients with pancreatic diseases, a rupture of the esophagus and a malignancy. However, there is no data available on...
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Effect of Steroid Administration Ex Vivo on the IkappaB/NF-kappaB Pathway in Human Peripheral Blood Monocytes

Yoon HI, Lee HS, Lee CH, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG

BACKGROUND: Synthetic glucocorticoids are widely used in many chronic inflammatory diseases because of their excellent anti-inflammatory activity. Enhancing the transcription of IkappaB and preventing activated NF-kappaB from binding to kappaB...
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Aspirin Reduces Acute Lung Injury in Rats Subjected to Severe Hemorrhage

Shin TR, Lee DU, Park YY

BACKGROUND: Hemorrhagic shock and trauma are two of the most common causes of acute lung injury. The activation of cyclooxygenase is one of the important causes of acute lung injury....
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Effect of Doxycycline on the Acute Lung Injury Induced by Gut Ischemia/Reperfusion

Lee YM, Kwon SC, Lee SC

BACKGROUND: Phospholipase A2 (PLA2) has been known to be involved in the pathogenesis of acute lung injury (ALI) including ARDS. Since doxycycline has the property of inhibiting secretory group II...
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Decreased Neutrophil Apoptosis in Patients with Sepsis is Related to the Activation of NF-kappaB

Kwon SY, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG

BACKGROUND: Neutrophil-mediated inflammation is usually self-limiting, because neutrophils have a remarkably short life span. Prolonged neutrophil survival, which is caused by decreased spontaneous apoptosis, leads to persistent inflammation in sepsis....
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The GSTT1 Genotype as A Marker for Susceptibility to Lung Cancer in Korean Female Never-Smokers

Jang SS, Jung CY, Lee SY, Lee JH, Jeon HS, Park SH, Son JW, Lee EB, Kim CH, Kam S, Park RW, Kim IS, Jung TH, Park JY

BACKGROUND: Most previous studies regarding the role of GSTMl and GSTT1 on lung cancer risk have been focused mainly on male smokers. However, epidemiological characteristics, histologic types and risk factors...
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