- Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells
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Lee SY, Ko KW, Kang WK, Choe YJ, Kim YH, Kim IK, Kim J, Kim HS
- KMID: 2071713
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):407-412.
- doi: 10.4196/kjpp.2010.14.6.407
3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced... -
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- Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity
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Kim HS, Jeong SY, Lee JH, Kim BE, Kim JW, Jeong SW, Kim IK
- KMID: 755099
- Exp Mol Med.
- 2000 Dec;32(4):197-203.
3-Deazaadenosine (DZA), one of the potent inhibitors of S-adenosylhomocysteine hydrolase, is known to possess several biological properties including an induction of apoptosis. To evaluate a possibility that DZA... -
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- Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction
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Chae YJ, Kim HS, Rhim HS, Kim BE, Jeong SW, Kim IK
- KMID: 1457543
- Exp Mol Med.
- 2001 Dec;33(4):284-292.
3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells. In this study, we analyzed the activation pathway of the caspase cascade involved... -
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