- Differential Inhibition of MPP+- or 6-Hydroxydopamine-induced Cell Viability Loss in PC12 Cells by Trifluoperazine and W-7
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Lee CS
- KMID: 1600082
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):247-253.
The present study assessed the effect of calmodulin antagonists trifluoperazine and W-7 against the cytotoxicity of MPP+ and 6-hydroxydopamine (6-OHDA) in relation to the mitochondrial dysfunction and cell death in... -
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- Depression of Ca2+ influx in complement C5a-stimulated neutrophils by calmodulin inhibitors
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Ham DS, Kim HH, Han ES, Lee CS
- KMID: 2071531
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):109-117.
Role of Ca2+/calmodulin complex in intracellular Ca2+ mobilization in neutrophils has not been clearly elucidated. In this study, effects of chlorpromazine, trifluoperazine and imipramine on the intracellular Ca2+ mobilization, including Ca2+ influx, in... -
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- Effects of Trifluoperazine on the PC12 Cell Injury
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Kim W, Choi Y, Lee HY, Kim Y, Lee KY
- KMID: 2275050
- Chonnam Med J.
- 1997 Jun;33(1):89-104.
Trifluoperazine(TFP) is a well known antipsycotic phenothiazine derivative. TFP is also known as a calmodulin antagonist in molecular level. Although there have been many reports on the role of TFP... -
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- Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells
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Shin SY, Kim CG, Hong DD, Kim JH, Lee YH
- KMID: 1094083
- Exp Mol Med.
- 2004 Aug;36(4):380-386.
The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many... -
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- The Effect of Vasodilators on the Cerebral Vasospasm Induced by Experimntal Subarachnoid Hemorrhage
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Cho HY, Doh SS, Shin H
- KMID: 2339531
- J Korean Neurosurg Soc.
- 1988 Oct;17(5):875-886.
This paper notes the effect of vasodilators on the cerebral vasospasm induced by experimental subarachnoid hemorrhage. Artificial subarachnoid hemorrhage produced by dual injection of non-heparinized autologous blood into the cisterna... -
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- Regulation of the contraction induced by emptying of intracellular Ca2+ stores in cat gastric smooth muscle
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Baek HJ, Sim SS, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS
- KMID: 1982597
- Korean J Physiol Pharmacol.
- 2000 Apr;4(2):113-120.
To investigate the mechanism of smooth muscle contraction induced by emptying of intracellular Ca2+ stores, we measured isometric contraction and 45Ca2+ influx. CaCl2 increased Ca2+ store emptying- induced contraction in dose-dependent manner, but... -
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- Effects of Ca2+ Antagonists and Protein Kinase Inhibitors on Ethanol-Induced Contraction of Cat Gastric Smooth Muscle
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Sim SS, Choi JC, Kim MS, Kim CJ, Jo YH
- KMID: 2240323
- Korean J Gastroenterol.
- 2000 May;35(5):539-545.
BACKGROUND/AIMS: The mechanism of ethanol in contraction of gastric smooth muscle still remains unclear. To investigate underlying mechanism of ethanol in tonic contraction, we measured isometric contractions of cat gastric smooth muscle using... -
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- Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells
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Lee DH, Lee CS
- KMID: 1512942
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):51-58.
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of... -
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- Effect of serum and hydrogen peroxide on the Ca2+/calmodulin-dependent phosphorylation of eukaryotic elongation factor 2(eEF-2) in Chinese hamster ovary cells
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Kang KR, Lee SY
- KMID: 1457530
- Exp Mol Med.
- 2001 Dec;33(4):198-204.
Eukaryotic elongation factor eEF-2 mediates regulatory steps important for the overall regulation of mRNA translation in mammalian cells and is activated by variety of cellular conditions and factors. In this... -
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