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Pharmacodynamic evaluation of YH4808 for Helicobacter pylori eradication in healthy subjects

Park H, Kim CO, Kim M, Lim Y, Lee WY, Yoon S, Park MS

YH4808 is a novel selective potassium-competitive acid blocker demonstrated to be safe and to have inhibitory effects against gastric acid secretion in previous studies. A randomized, open-label, multiple-dose, 3-treatment, 1-period,...
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Qualification and application of liquid chromatography-quadrupole time-offlight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling

Lee Bi, Lim Jh, Park MH, Shin SH, Byeon JJ, Choi Jm, Park Sj, Park Mj, Park Y, Shin YG

Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied...
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Predicting human pharmacokinetics from preclinical data: absorption

Yim DS, Choi S, Bae SH

Predicting the rate and extent of oral absorption of drugs in humans has been a challenging task for new drug researchers. This tutorial reviews in vivo and PBPK methods reported...
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Bioequivalence of the pharmacokinetics between tofacitinib aspartate and tofacitinib citrate in healthy subjects

Shin W, Yang AY, Yun H, Cho DY, Park KH, Shin H, Kim A

Tofacitinib is an oral disease-modifying anti-rheumatic drug to selectively inhibit Janus kinases. Tofacitinib is a representative small molecule inhibitor that is used to treat many diseases including rheumatoid arthritis and...
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Introduction to dynamical systems analysis in quantitative systems pharmacology: basic concepts and applications

Chae D

Quantitative systems pharmacology (QSP) can be regarded as a hybrid of pharmacometrics and systems biology. Here, we introduce the basic concepts related to dynamical systems theory that are fundamental to...
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