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Pharmacokinetic comparison of two bazedoxifene acetate 20 mg tablet formulations in healthy Korean male volunteers

Yeun JS, Kan HS, Lee M, Kim N, Oh TY, Nam SK, Choi YS, Kwon IS, Hong JH

Bazedoxifene, used as bazedoxifene acetate, is a selective estrogen receptor modulator that selectively affects the uterus, breast tissue, bone metabolism, and lipid metabolism by antagonizing or enhancing estrogens in the...
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Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects

Lee HW, Kang WY, Jung W, Gwon MR, Yang DH, Kim EH, Cho K, Yoon YR, Seong SJ

This study compared the pharmacokinetics of a fixed-dose combination (FDC) of candesartan (16 mg) and amlodipine (10 mg) versus coadministration of individual formulations to clarify the bioequivalence of the FDC....
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Validation of “sasLM,” an R package for linear models with type III sum of squares

Sunwoo J, Kim H, Choi D, Bae KS

The general linear model (GLM) describes the dependent variable as a linear combination of independent variables and an error term. The GLM procedure of SAS® and the “car” package in...
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Development and validation of a method for the simultaneous quantification of endogenous steroids metabolized by CYP3A

Lee Y, Chae W, Yoon S, Chung JY, Cho JY

Cytochrome P450 (CYP) 3A enzymes, the most important phase 1 drug-metabolizing enzymes, are responsible for 50% of the metabolism of clinically used drugs. CYP3A activity varies widely among individuals, which...
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Common data model-based real-world data for practical clinical practice guidelines: clinical pharmacology perspectives

Jeon Y, Choi Y, Kim EH, Oh S, Lee H

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