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Electronic medical records-based comparison of glycemic control efficacy between sulfonylureas and dipeptidyl peptidase-4 inhibitors added on to metformin monotherapy in patients with type 2 diabetes

Lee S, Lee S, Jang IJ, Yu KS, Rhee Sj

Sulfonylurea (SU) and dipeptidyl peptidase-4 (DPP-4) inhibitors are most common secondary agents that are added to metformin monotherapy. Real-world studies have become increasingly important in providing evidence of treatment effectiveness...
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Bioequivalence data analysis

Park G, Kim H, Bae KS

SAS® is commonly used for bioequivalence (BE) data analysis. R is a free and open software for general purpose data analysis, and is less frequently used than SAS® for BE...
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Predicting human pharmacokinetics from preclinical data: volume of distribution

Yim DS, Choi S

This tutorial introduces background and methods to predict the human volume of distribution (Vd ) of drugs using in vitro and animal pharmacokinetic (PK) parameters. The physiologically based PK (PBPK)...
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Pharmacogenomic information from CPIC and DPWG guidelines and its application on drug labels

Yoon DY, Lee S, Ban MS, Jang IJ, Lee S

There are several hurdles to overcome before implementing pharmacogenomics (PGx) in precision medicine. One of the hurdles is unawareness of PGx by clinicians due to insufficient pharmacogenomic information on drug...
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Evaluation of the pharmacokinetics and food effects of a novel formulation tamsulosin 0.4 mg capsule compared with a 0.2 mg capsule in healthy male volunteers

Ban MS, Kim YK, Kim B, Jung J, Kim Yi, Oh J, Yu KS

Tamsulosin, an alpha-1 adrenoreceptor antagonist, has been used as a primary option for medical treatment of benign prostate hyperplasia. An open-label, single-dose, randomized, three-treatment, three-period, three sequence crossover study was...
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