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Erratum: R-based reproduction of the estimation process hidden behind NONMEM Part 2: First-order conditional estimation

Bae KS, Yim DS

The equations on page 162 should be corrected.
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Pharmacodynamic principles and the time course of delayed and cumulative drug effects

Holford N

This tutorial reviews the principles of the concentration — effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining...
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Data exclusivity through New Drug Reexamination in Korea: sibutramine hydrochloride (Reductil®) vs. sibutramine mesylate (Slimmer®) as an example

Lee H

The ‘equivalent-or-more-but-not-the-same-data’ provision in the Regulation on the Safety and Efficacy Evaluation of New Drug in Korea has served as the de facto data exclusivity term for any drug identical...
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The first step to the powers for clinical trials: a survey on the current and future Clinical Trial Management System

Park JS, Moon SJ, Lee JH, Jeon JY, Jang K, Kim MG

A clinical trial management system (CTMS) is a comprehensive program that supports an efficient clinical trial. To improve the environment of clinical trials and to be competitive in the global...
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Effect of plasma membrane monoamine transporter genetic variants on pharmacokinetics of metformin in humans

Moon SJ, Oh J, Lee SH, Choi Y, Yu KS, Chung JY

Metformin, an oral hypoglycemic agent belonging to biguanide class, is widely used to treat type 2 diabetes mellitus, and several drug transporters such as organic cation transporters (OCTs), multidrug and...
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Population pharmacodynamics of cilostazol in healthy Korean subjects

Jung YS, Chae D, Park K

Cilostazol is used for the treatment of intermittent claudication, ulceration and pain. This study was conducted to develop a population pharmacodynamic (PD) model for cilostazol's closure time (CT) prolongation effect...
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Pharmacokinetics comparison of solifenacin tartrate and solifenacin succinate: a randomized, open-label, single-dose, 2-way crossover study in healthy male volunteers

Kim YM, Jeon JY, Moon SJ, Jung J, Son H, Kim MG

Solifenacin is a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms. Solifenacin tartrate is a newly developed salt formulation of solifenacin. This study compared the pharmacokinetic and...
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Successful additional clarithromycin and tacrolimus treatment for hypereosinophilia associated with eosinophilic granulomatosis with polyangiitis

Ohe M, Shida H, Horita T, Furuya K

A 41-year-old man suffering from eosinophilic granulomatosis with polyangiitis (EPGA), diagnosed at another clinic on the basis of American College of Rheumatology Criteria, with a history of bronchial asthma, eosinophilia,...
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Determination of donepezil in human plasma using ultra performance liquid chromatography-tandem mass spectrometry

Jeong HC, Park JE, Hyun JY, Park MK, Shin DS, Shin KH

An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantification of donepezil in human plasma. Donepezil and donepezil-D4 were extracted from human plasma by...
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